Category: 99-93-4

Recommanded Product: 99-93-4. Authors Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R in ROYAL SOC CHEMISTRY published article about in [Haefliger, Joel; Livingstone, Keith; Daniliuc, Constantin G.; Gilmour, Ryan] Westfalische Wilhelms Univ Munster, Organ Chem Inst, D-48149 Munster, Germany in 2021.0, Cited 17.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Simple alpha-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor (R) and simple amine center dot HF complexes. Modulating Bronsted acidity enables simultaneous geminal and vicinal difluorination to occur, thereby providing a platform to generate multiply fluorinated scaffolds for further downstream derivatization. The method facilitates access to a tetrafluorinated API candidate for the treatment of amyotrophic lateral sclerosis. Preliminary validation of an enantioselective process is disclosed to access alpha-phenyl-beta-difluoro-gamma-bromo/chloro esters.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4′-Hydroxyacetophenone. In 2019.0 ACS OMEGA published article about HYBRID COMPOUNDS; CYTOTOXIC ACTIVITY; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; IMIDAZOLE; ISOLIQUIRITIGENIN; DERIVATIVES; INHIBITION; ANALOGS in [Yang, Jun-Li; Ma, Yong-Hui; Zhang, Yi-Peng; Tian, Hong-Chang; Huang, Yuan-Cheng; Chen, Wen] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; [Yang, Jun-Li; Li, Yan-Hua; Yang, Li-Juan] Yunnan Minzu Univ, Engn Res Ctr Green Preparat Technol Biobased Mat, Sch Chem & Environm, Kunming 650500, Yunnan, Peoples R China; [Li, Yan] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China in 2019.0, Cited 44.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A series of novel trimethoxyphenyl-derived chalcone-benzimidazolium salts were synthesized. The biological properties of the compounds were screened in vitro against five different human tumor cell lines. The results suggest that the 5,6-dimethyl-benzimidazole or 2-methyl-benzimidazole ring as well as the 2-naphthylmethyl, 4-methylbenzyl, or 2-naphthylacyl substituent at position-3 of the benzimidazole ring was important to the cytotoxic activity. Notably, (E)-5,6-dimethy1-3-(naphth alen-2-ylmethyl)-1-(3-(4-(3-(3,4,5-trime thoxyphenyl) a cryloyl) phenoxy)propyl)-1H-benzo [d] imidazol-3-ium bromide (7f) was more selective to HL-60, MCF-7, and SW-480 cell lines with IC50 values 8.0-, 11.1-, and 5.8-fold lower than DDP. Studies of the antitumor mechanism of action showed that compound 7f could induce cell-cycle G1 phase arrest and apoptosis in SMMC-7721 cells.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yang, JL; Ma, YH; Li, YH; Zhang, YP; Tian, HC; Huang, YC; Li, Y; Chen, W; Yang, LJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Liu, L; She, MY; Zhang, J; Wang, ZH; Liu, H; Tang, M; Liu, P; Zhang, SY; Li, JL in [Liu, Lang; She, Mengyao; Zhang, Jun; Wang, Zhaohui; Liu, Hua; Tang, Mi; Liu, Ping; Zhang, Shengyong; Li, Jianli] Northwest Univ, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Coll Chem & Mat Sci, Xian 710127, Shaanxi, Peoples R China; [She, Mengyao] Northwest Univ, Key Lab Resource Biol & Modern Biotechnol Western, Minist Educ, Coll Life Sci,Fac Life & Hlth Sci, Xian 710069, Shaanxi, Peoples R China published A practical strategy for construction and regulation of multi-functional triazepinium salts via highly efficient I-2-catalyzed cyclization in 2020, Cited 60. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Synthesis of new functional organic molecules is a critical path that may greatly accelerate the evolution of organic optoelectronic materials. We have achieved a facile synthesis strategy to produce unique saddle-shaped multi-functional triazepinium salts that exhibit excellent solid-state fluorescence. Their fluorescence performance could be easily regulated by adjusting the dihedral angle between the main skeleton and the substituted moiety, giving a large Stokes shift, non-aggregation quenching, long lifetime, and multilevel-redox characteristics.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Liu, L; She, MY; Zhang, J; Wang, ZH; Liu, H; Tang, M; Liu, P; Zhang, SY; Li, JL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about DISCOVERY; DESIGN; POTENT; STAPHYLOCOCCI; OPTIMIZATION; IV in [Ghannam, Iman A. Y.; Abd El-Meguid, Eman A.; Ali, Islam H.; Sheir, Donia H.] Natl Res Ctr, Pharmaceut & Drug Ind Res Div, Chem Nat & Microbial Prod Dept, Cairo 12622, Egypt; [El Kerdawy, Ahmed M.] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Kasr El Aini St,POB 11562, Cairo, Egypt; [El Kerdawy, Ahmed M.] Cairo Univ, Mol Modeling Unit, Fac Pharm, Kasr El Aini St,POB 11562, Cairo, Egypt; [El Kerdawy, Ahmed M.] New Giza Univ, Dept Pharmaceut Chem, Fac Pharm, Km 22 Cairo Alexandria Desert Rd, Cairo, Egypt in 2019.0, Cited 41.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

A series of new 2-arylbenzothiazole derivatives (4, 5, 6a-j, 7a-i and 8a,b) was synthesized and tested for their antimicrobial activity against different Gram-positive, Gram-negative bacteria and yeast using ciprofloxacin and fluconazole as positive controls for the antibacterial and antifungal activities, respectively. The target compounds showed stronger inhibitory activity against Gram-negative than Gram-positive bacteria. The minimum inhibitory concentration (MIC) values were determined for those compounds showed zone of inhibition >= 13 mm. Based on the MIC values for the tested compounds against E. coli, compounds (4, 5, 6c, 6d, 6g, 6i, 6j, 7b, 7c, 7g and 8a) were selected and tested for their E. coli gyrase inhibitory activity. The tested compounds showed moderate inhibitory activity against E. coli gyrase. Compounds 5, 6c, 6i, 6j and 7b displayed high inhibitory activity against E. coli gyrase with IC50 values below 10 mu M, however, they were less active than ciprofloxacin (E. coli gyrase IC50 = 1.14 mu M). The p-hydroxy-m-methoxy benzothiazole analogue 6c was the most active tested compound (E. coli gyrase IC50 = 4.85 mu M). Quantitative structure-activity relationship (QSAR) study was also implemented for the newly synthesized compounds. The QSAR study indicated that the structural feature that governs the anti-microbial activity for the newly synthesized benzothiazole derivatives is their structural hydrophilic-lipophilic balance what agrees with the chemical intuition where this balance governs their cellular absorption and so their antimicrobial activity. Molecular docking showed that the newly synthesized compounds possess the required structural feature for E. coli gyrase B inhibition through interaction with the key amino acids Asp73 and Gly77.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ghannam, IAY; Abd El-Meguid, EA; Ali, IH; Sheir, DH; El Kerdawy, AM or concate me.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones WOS:000509895700019 published article about ARYLOXIME ETHERS; OXIME ETHERS; PHENYLBORONIC ACIDS; REARRANGEMENT; BENZOFURANS; CYCLIZATION; ARYLATION; DERIVATIVES; COMPLEX in [Reeta; Kaushik, Kumar; Singh, Raj Pal] DRDO, Ctr Fire Explos & Environm Safety, Delhi, India; [Reeta] Univ Delhi, Dept Chem, Delhi, India; [Rangarajan, T. M.; Singh, Rishi Pal] Univ Delhi, Sri Venkateswara Coll, Dept Chem, New Delhi, India; [Singh, Manjula] Univ Delhi, Shivaji Coll, Dept Chem, New Delhi, India in 2020.0, Cited 69.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C-O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand tBuXPhos (L2) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Reeta; Rangarajan, TM; Kaushik, K; Singh, RP; Singh, M; Singh, RP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ACUTE LIVER-INJURY; OXIDATIVE STRESS; SELECTIVE VISUALIZATION; PHOTODYNAMIC THERAPY; RAT-LIVER; ACID; MITOCHONDRIA; NEUTROPHILS; CANCER; MACROPHAGES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21874059]. HPLC of Formula: C8H8O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Long, LL; Han, YY; Liu, WG; Chen, Q; Yin, DD; Li, LL; Yuan, F; Han, ZX; Gong, AH; Wang, K. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Hypochlorite (ClO-) and singlet oxygen (O-1(2)) commonly coexist in living systems and exert important interplaying roles in many diseases. To dissect their complex inter-relationship, it is urgently required to construct a fluorescent probe that can discriminate ClO- and O-1(2) in living organisms. Herein, by taking the 3-(aliphaticthio)-propan-1-one group as the unique recognition unit for both ClO- and O-1(2), we proposed the first fluorescent probe, Hy-2, to simultaneously discriminate ClO- and O-1(2) with high sensitivity and selectivity. Probe Hy-2 itself showed fluorescence in blue channel. After treatment with ClO- and O-1(2), respectively, pronounced fluorescence enhancements were observed in the green channel and red channel correspondingly. Moreover, upon development of the probe with aggregation-induced emission (AIE) characteristics, the probe could work well in a solution with high water volume fraction. Probe Hy-2 was also able to accumulate into mitochondria and was utilized as an effective tool to image exogenous and endogenous ClO- and O-1(2) in mitochondria. Significantly, as the first trial, probe Hy-2 was employed to simultaneously monitor the variation of ClO- and O-1(2) level in cecal tissues of rat in the cecal ligation and puncture (CLP)-induced polymicrobial sepsis model. The results demonstrated that the expressed ClO- and O-1(2) levels were tightly correlated with the severity of sepsis, inferring that the overproduction of ClO- and O-1(2) is an important factor in the pathogenesis of sepsis. The probe illustrated herein may provide a guide for further exploring the functions of ClO- and O-1(2) in various diseases.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Long, LL; Han, YY; Liu, WG; Chen, Q; Yin, DD; Li, LL; Yuan, F; Han, ZX; Gong, AH; Wang, K or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Baran, A; Karakilic, E; Faiz, O; Ozen, F in [Baran, Arif; Karakilic, Emel; Ozen, Furkan] Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54187 Sakarya, Turkey; [Faiz, Ozlem] RTE Univ, Fac Arts & Sci, Dept Chem, TR-53100 Rize, Turkey published Synthesis of chalcone-containing zinc and cobalt metallophthalocyanines; investigation of their photochemical, DPPH radical scavenging and metal chelating characters in 2020.0, Cited 45.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In this study, two new phthalocyanines (M = Zn and Co) were synthesized using the (E)-4-(4-(3-(4-(benzyloxy)phenyl)acryloyl)phenoxy)phthalonitrile (3) as ligand prepared from the chemical reaction of 4-nitrophthalonitrile with (E)-3-(4-(benzyloxy)phenyl)-1-(4-hydroxyphenyl)prop-2-en-l-one (2). All compounds were characterized using by H-1-NMR, C-13-NMR, UV-Vis, FT-IR, and MALDI-TOF mass spectra. Singlet oxygen quantum yields of the synthesized compounds, aggregates in different solutions, metal chelating and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging properties were reported.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Baran, A; Karakilic, E; Faiz, O; Ozen, F or concate me.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article High dielectric, low curing with high thermally stable renewable eugenol-based polybenzoxazine matrices and nanocomposites WOS:000451334300001 published article about RING-OPENING POLYMERIZATION; BIO-BASED BENZOXAZINES; POLYMERS; MONOMERS; CARDANOL; CURE in [Krishnan, S.; Arumugam, H.; Chavali, M.; Muthukaruppan, A.] Vignans Univ, Ctr Excellence Adv Mat Mfg Proc & Characterizat C, Guntur 522213, India in 2019.0, Cited 36.0. Application In Synthesis of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

In the present work, a new type of bio-based benzoxazines were prepared by using aniline, N, N-dimethyl amino propyl amine (DMAPA) and caprolactam modified DMAPA with eugenol. The benzoxazines resulted were characterized for their molecular structure by Fourier transform infrared and nuclear magnetic resonance spectroscopy. The polymerization process of benzoxazines and their thermal behavior were studied by differential scanning calorimetry and thermogravimetric analysis, respectively. Moreover, the effect of chemical blending of the synthesized benzoxazines with conventional benzoxazines [bisphenol A benzoxazine (BPAb) and bisphenol F benzoxazine (BPFb)] and bismaleimide was studied to bring down the polymerization temperature by creating supplementary potential sites for polymerization. Furthermore, to reduce the polymerization temperature, the benzoxazines synthesized in the present study were partially incorporated with 10 wt % of catalysts (4-hydroxy phenylmaleimide, 4-amino phenol, and 4-hydroxy acetophenone). The graphene reinforced polybenzoxazine composites were also prepared by incorporating varying weight percentages (1, 3, 5, 7, and 10 wt %) of graphene oxide to obtain hybrid nanocomposites. From the results obtained, it was observed that the polymerization temperature (T-p) was significantly reduced (more than 31 degrees C) in both the cases of blends of conventional BPAb and BPFb. It was also observed that the values of the dielectric constant of graphene reinforced hybrid composites are significantly enhanced. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47050.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Krishnan, S; Arumugam, H; Chavali, M; Muthukaruppan, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 ORG LETT published article about PHOSPHINE-PHOSPHITE LIGANDS; ASYMMETRIC HYDROCYANATION; GRIGNARD-REAGENTS; ALKENES; 1,4-ADDITION; VINYLARENES; COMPLEXES in [Yu, Rongrong; Fang, Xianjie] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2020.0, Cited 43.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

A vast range of novel TADDOL-based diphosphite ligands were first synthesized and applied in the nickel-catalyzed asymmetric hydrocyanation of disubstituted methylenecyclopropanes. By employing these new catalysts, the conversion of diverse methylenecyclopropanes into their corresponding allylic nitriles was first enabled, in good yield with excellent enantioselectivities.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yu, RR; Fang, XJ or concate me.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article DABCO Catalyzed Synthesis of beta-Hydroxy Ketones Derived from alpha-Methyl Ketones and Ninhydrin under Microwave Irradiations published in 2019.0. Name: 4′-Hydroxyacetophenone, Reprint Addresses Srivastava, V (corresponding author), Banaras Hindu Univ, Dept Chem, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Microwave induced an efficient, green and rapid protocol for the synthesis of 2-substituted-2-hydroxyindan-1,3-dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4-diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal-free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, P; Mishra, A; Chauhan, S; Singh, S; Srivastava, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles