Category: 99-93-4

An article Solid-liquid extraction of iodide and bromide from aqueous media by a new water-insoluble phenoxycalix[4]pyrrole-epichlorohydrin polymer WOS:000479062100009 published article about ANION-BINDING; RECOGNITION; RECEPTORS; CAVITY in [AlHaddad, Nancy; Cazier-Dennin, Francine; Danjou, Pierre-Edouard] Univ Littoral Cote dOpale, Unite Chim Environm & Interact Vivant, EA 4492, 145 Ave Maurice Schumann,MREI 1, Dunkerque, France; [AlHaddad, Nancy; Rifai, Ahmad] Lebanese Natl Council Sci Res, Lebanese Atom Energy Commiss, BP 11-8281, Beirut 11072260, Lebanon; [Kasprowiak, Amaury] Univ Littoral Cote dOpale, Dept Chim, 220 Ave Univ, Dunkerque, France in 2019.0, Cited 29.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

The present study describes the synthesis of the first phenoxycalix[4]pyrrole-epichlorohydrin based polymer. The advantage of the latter resides in its fast-single step synthesis protocol, low cost, water insolubility and its unexpected anion extraction capacity. The study of this polymer by various solid/liquid extractions with halides in aqueous solutions and quantitative ion chromatography analysis showed that unlike other calix[4]pyrrole-based entities, this polymer extracts iodide rather than bromide and fluoride owing to the presence of large extraction pockets. Evidence of an anion exchange process involving preferably chloride and bromide was also highlighted.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact AlHaddad, N; Rifai, A; Kasprowiak, A; Cazier-Dennin, F; Danjou, PE or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Science & Technology – Other Topics very interesting. Saw the article A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification published in 2020.0. Application In Synthesis of 4′-Hydroxyacetophenone, Reprint Addresses Wu, JR (corresponding author), Beijing Univ Chinese Med, Beijing 100102, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Yinzhihuang granules (YZHG) is a patented Chinese medicine for the treatment of hepatitis B. This study aimed to investigate the intrinsic mechanisms of YZHG in the treatment of hepatitis B and to provide new evidence and insights for its clinical application. The chemical compounds of YZHG were searched in the CNKI and PUBMED databases, and their putative targets were then predicted through a search of the SuperPred and Swiss Target Prediction databases. In addition, the targets of hepatitis B were obtained from TTD, PharmGKB and DisGeNET. The abovementioned data were visualized using Cytoscape 3.7.1, and network construction identified a total of 13 potential targets of YZHG in the treatment of hepatitis B. Molecular docking verification showed that CDK6, CDK2, TP53 and BRCA1 might be strongly correlated with hepatitis B treatment. Furthermore, GO and KEGG analyses indicated that the treatment of hepatitis B by YZHG might be related to positive regulation of transcription, positive regulation of gene expression, the hepatitis B pathway and the viral carcinogenesis pathway. Network pharmacology intuitively shows the multicomponent, multitarget and multichannel pharmacological effects of YZHG in the treatment of hepatitis B and provides a scientific basis for its mechanism of action.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhang, JY; Liu, XK; Zhou, W; Cheng, GL; Wu, JR; Guo, SY; Jia, SS; Liu, YY; Li, BB; Zhang, XM; Wang, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Recently I am researching about OXIDATION; TITANIUM; ELECTROCATALYSIS; EFFICIENCY; OXIDES, Saw an article supported by the Center for Molecular Electrocatalysis, an Energy Frontier Research Center – U.S. Department of Energy, Office of Science, Office of Basic Energy SciencesUnited States Department of Energy (DOE). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wise, CF; Mayer, JM. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Redox reactions at metal oxide (MOx) surfaces are implicated in many catalytic and energy conversion processes involving proton-coupled electron transfer (PCET). Nonetheless, the fundamental thermodynamics dictating PCET reactivity at the MOx/solution interface are not well understood. Herein, we connect the pH-dependent electrochemical response of MOx thin films with the bond dissociation free energies (BDFEs) of their electroactive surface O-H bonds, using NiO as a case study. Complementary voltammetric and spectroscopic experiments show that the electrochemically determined BDFEs predict much of the observed PCET reactivity at the NiO surface. Analyzing the reactivity of MOx materials in terms of BDFEs could enable new approaches for designing more active and efficient (electro)catalysts for important PCET reactions.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wise, CF; Mayer, JM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2019.0 MONATSH CHEM published article about COMPLEXES; RELEASE in [Zhao, Zhi Xiang; Li, Ting; Cheng, Li Ping; Li, Meng; Zhong, Zhi Jian; Pang, Wan] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China in 2019.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Schiff-bases have important applications in the field of analysis, biomedicine, as well as material sciences. Hydrazones and acylhydrazones are two representative types of Schiff-bases. In this study, a green synthesis of aromatic hydrazones and acylhydrazones via Schiff-base reaction of aryl ketones and aromatic acylhydrazines/hydrazines had been reported. In the synthesis, water was used as solvent and AlCl3 center dot 6H(2)O was used as catalyst. The reaction is simple, highly efficient, and eco-friendly. [GRAPHICS] .

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhao, ZX; Li, T; Cheng, LP; Li, M; Zhong, ZJ; Pang, W or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Asparagine as a Green Organocatalyst for the Synthesis of 2-Aminothiazoles published in 2020.0. Computed Properties of C8H8O2, Reprint Addresses Safari, J (corresponding author), Univ Kashan, Coll Chem & Biochem, Dept Organ Chem, Lab Organ Compound Res, Kashan, IR, Iran.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

In this research, an efficient method for the one-pot synthesis of 2-aminothiazolesviathe reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80 degrees C in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation.

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Safari, J; Shokrani, Z; Zarnegar, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Copper-Impregnated Magnesium-Lanthanum Mixed Oxide: A Reusable Heterogeneous Catalyst for Allylation of Aldehydes and Ketones WOS:000510048100001 published article about METAL-MEDIATED ALLYLATION; BARBIER-TYPE ALLYLATION; ALUMINUM-PROMOTED ALLYLATION; CARBON BOND FORMATION; AQUEOUS-MEDIA; ORGANOMETALLIC REACTIONS; CHEMOSELECTIVE ALLYLATION; IN-SITU; ASYMMETRIC ALLYLATION; EFFICIENT ALLYLATION in [Pogula, Jaya] Acad Sci & Innovat Res AcSIR, New Delhi, India; [Pogula, Jaya; Laha, Soumi; Likhar, Pravin R.] CSIR Indian Inst Chem Technol, Catalysis & Fine Chem Dept, Hyderabad, India; [Sreedhar, B.] CSIR Indian Inst Chem Technol, Analyt Dept, Hyderabad, India in 2020.0, Cited 85.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

Copper-impregnated magnesium-lanthanum mixed oxide [Cu(II)/Mg-La] was used as catalyst in synthesis of homoallylic alcohols from aldehydes and ketones using allyltributylstannane as the allylating source. The present protocol provides a great application potential for the synthesis of corresponding allyl alcohols with excellent yields and selectivity. The catalyst exhibits broad functional group compatibility with a variety of substituted aldehydes and ketones to furnish the desired products in high yields under heterogeneous conditions. Importantly, the heterogeneous catalyst could be recovered from the reaction mixture by centrifugation and used up to three cycles.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Pogula, J; Laha, S; Sreedhar, B; Likhar, PR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2020.0 ANGEW CHEM INT EDIT published article about SELECTIVE BIOCONJUGATION; ALKYLATION; PROTEINS in [Tobiesen, Henriette N.; Leth, Lars A.; Iversen, Marc V.; Naesborg, Line; Jorgensen, Karl Anker] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark; [Tobiesen, Henriette N.; Bertelsen, Soren] Novo Nordisk AS, Global Res Technol, Res Chem, DK-2760 Malov, Denmark in 2020.0, Cited 36.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The first stereoselective, near-equimolar, and metal-free oxidative bioconjugation of amino acids and oligopeptides to aldehydes is presented. Based on a newly developed organocatalytic oxidative concept, the C-terminal and side-chain carboxylic acid functionalities of amino acids and oligopeptides are shown to couple in a stereoselective manner to alpha-branched aldehydes catalyzed by a chiral primary amine and a quinone as oxidizing agent. The oxidative coupling generally proceeds in high yield. For aspartic acid, selective coupling of the side-chain, or the C-terminal carboxylic acid, is demonstrated depending on the protection strategy. The stereoselective, oxidative bioconjugation concept is extended to a series of oligopeptides where coupling to carboxylic acid functionalities is presented. Bioorthogonal linker molecules for further functionalization are obtained by merging the oxidative coupling strategy with the click concept. It is demonstrated that the configuration of the new stereocenter is determined exclusively by the organocatalyst.

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Tobiesen, HN; Leth, LA; Iversen, MV; Naesborg, L; Bertelsen, S; Jorgensen, KA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, YM; Tang, CR; Rui, RM; Yang, LM; Ding, W; Wang, JY; Li, YM; Lai, CC; Wang, YP; Luo, RH; Xiao, WL; Zhang, HB; Zheng, YT; He, YP in [Wu, Yumeng; Rui, Ruomei; Ding, Wei; Wang, Jiangyuan; Li, Yiming; Wang, Yueping; Xiao, Weilie; Zhang, Hongbing; He, Yanping] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China; [Tang, Chengrun; Yang, Liumeng; Luo, Ronghua; Zheng, Yongtang] Chinese Acad Sci, Natl Kunming High Level Biosafety Res Ctr Nonhuma, Key Lab Bioact Peptides Yunnan Prov,Key Lab Anim, Kunming Inst Zool,KIZ CUHK Joint Lab Bioresources, Kunming 650223, Yunnan, Peoples R China; [Lai, Christopher C.] NCI, Chem Biol Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA; [Tang, Chengrun] Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China; [Tang, Chengrun] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China published Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors in 2020.0, Cited 40.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones were synthesized and their anti-HIV-1 activities were evaluated. Most of these compounds were highly active against wild-type (WT) HIV-1 strain (IIIB) with EC50 values in the range of 0.0038-0.4759 mmol/L. Among those compounds, I-11 had an EC50 value of 3.8 nmol/L and SI (selectivity index) of up to 25,468 indicating excellent activity against WT HIV-1. In vitro anti-HIV-1 activity and resistance profile studies suggested that compounds I-11 and I-12 displayed potential anti-HIV-1 activity against laboratory adapted strains and primary isolated strains including different subtypes and tropism strains (EC(50)s range from 4.3 to 63.6 nmol/L and 18.9-219.3 nmol/L, respectively). On the other hand, it was observed that those two compounds were less effective with EC50 values of 2.77 and 4.87 mmol/L for HIV-1A(17) (K103N + Y181C). The activity against reverse transcriptase (RT) was also evaluated for those compounds. Both I-11 and I-12 obtained sub-micromolar IC50 values showing their potential in RT inhibition. The pharmacokinetics examination in rats indicated that compound I-11 has acceptable pharmacokinetic properties and bioavailability. Preliminary structure-activity relationships and molecular modeling studies were also discussed. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wu, YM; Tang, CR; Rui, RM; Yang, LM; Ding, W; Wang, JY; Li, YM; Lai, CC; Wang, YP; Luo, RH; Xiao, WL; Zhang, HB; Zheng, YT; He, YP or concate me.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4′-Hydroxyacetophenone. In 2019.0 J MED CHEM published article about POSITIVELY SUPERCOILED DNA; DESIGN; RELAXATION; ANTICANCER; EXPRESSION; INHIBITORS; PYRIDINES; CHLORINE; CELLS in [Kadayat, Tara Man; Shrestha, Aarajana; Katila, Pramila; Shrestha, Ritina; Nepal, Mahesh Raj; Noh, Keumhan; Jeong, Tae Cheon; Lee, Eung-Seok] Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; [Park, Seojeong; Jo, Hyunji; Hwang, Soo-Yeon; Kwon, Youngjoo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 120750, South Korea; [Kadayat, Tara Man] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; [Kim, Sang Kyoon; Koh, Woo-Suk; Kim, Kil Soo; Jeon, Yong Hyun] Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; [Kim, Kil Soo] Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea in 2019.0, Cited 34.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

With the aim of developing new effective topoisomerase II alpha-targeted anticancer agents, we synthesized a series of hydroxy- and halogenated 2,4-diphenyl indeno[1,2-b]pyridinols using a microwave-assisted single step synthetic method and investigated structure-activity relationships. The majority of compounds with chlorophenyl group at 2-position and phenol group at the 4-position of indeno[1,2-b]pyridinols exhibited potent antiproliferative activity and topoisomerase H alpha-selective inhibition. Of the 172 compounds tested, 89 showed highly potent and selective topoisomerase H alpha inhibition and antiproliferative activity in the nanomolar range against human T47D breast (2.6 nM) cancer cell lines. In addition, mechanistic studies revealed compound 89 is a nonintercalative topoisomerase II poison, and in vitro studies showed it had promising cytotoxic effects in diverse breast cancer cell lines and was particularly effective at inducing apoptosis in T47D cells. Furthermore, in vivo administration of compound 89 had significant antitumor effects in orthotopic mouse model of breast cancer.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kadayat, TM; Park, S; Shrestha, A; Jo, H; Hwang, SY; Katila, P; Shrestha, R; Nepal, MR; Noh, K; Kim, SK; Koh, WS; Kim, KS; Jeon, YH; Jeong, TC; Kwon, Y; Lee, ES or concate me.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Engineering very interesting. Saw the article Catalytic ozonation of Bisphenol A in aqueous solution by Fe3O4-MnO2 magnetic composites: Performance, transformation pathways and mechanism published in 2020.0. Product Details of 99-93-4, Reprint Addresses Lai, B (corresponding author), Sichuan Univ, State Key Lab Hydraul & Mt River Engn, Coll Architecture & Environm, Chengdu 610065, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

In this study, Fe3O4-MnO2 magnetic composites were prepared and used as catalyst for the catalytic ozonation of BPA in aqueous solution. First, characterization results proved that Fe3O4-MnO2 magnetic composites were prepared successfully. Meanwhile, the advantage of Fe3O4-MnO2/O-3 system was demonstrated by control experiments. The degradation efficiency of BPA in Fe3O4-MnO2 process reached 97.0% under the conditions: Fe3O4-MnO2 = 100 mg/L, O-3 flow rate = 100 mL/min, initial solution pH = 7.0. In addition, the effects of catalyst dosage, O-3 flow rate and initial solution pH on the degradation of BPA were studied respectively. Moreover, the recyclability and stability of Fe3O4-MnO2 magnetic composites were also investigated. The results showed that Fe3O4-MnO2 magnetic composites have high catalytic activity, stability and recyclability for BPA degradation. Furthermore, the degradation intermediates of BPA were detected and the degradation pathways of BPA were proposed comprehensively. Finally, the possible reaction mechanism of Fe3O4-MnO2/O-3 process was proposed. In brief, all the results confirmed that the Fe3O4-MnO2/O-3 process was a simple, nonhazardous, efficient and promising technology for the degradation of BPA in aqueous solution.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhang, H; He, YL; Lai, LD; Yao, G; Lai, B or concate me.. Product Details of 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles