Category: 99-93-4

Recommanded Product: 4′-Hydroxyacetophenone. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design and Synthesis of Novel Cytotoxic Indole-Thiosemicarbazone Derivatives: Biological Evaluation and Docking Study published in 2019.0, Reprint Addresses Saghaie, L (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Med Chem, Esfahan 8174673461, Iran.; Mahdavi, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Endocrinol & Metab Res Ctr, Tehran 1417653761, Iran.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.

In this work, two novel series of indole-thiosemicarbazone derivatives were designed, synthesized, and evaluated for their cytotoxic activity against MCF-7, A-549, and Hep-G2cell lines in comparison to etoposide and colchicine as the reference drugs. Generally, the synthesized compounds showed better cytotoxicity towards A-549 and Hep-G2 than MCF-7. Among them, (2E)-2-{[2-(4-chlorophenyl)-1H-indol-3-yl]methylidene}-N-(4-methoxyphenyl)hydrazinecarbothioamide (8l) was found to be the most potent compound against A-549 and Hep-G2, at least three times more potent than etoposide. The morphological analysis by the acridine orange/ethidium bromide double staining test and flow cytometry analysis indicated that compound 8l induced apoptosis in A-549 cells. Moreover, molecular docking methodology was exploited to elucidate the details of molecular interactions of the studied compounds with putative targets.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bakherad, Z; Safavi, M; Fassihi, A; Sadeghi-Aliabadi, H; Bakherad, M; Rastegar, H; Saeedi, M; Ghasemi, JB; Saghaie, L; Mahdavi, M or concate me.. Recommanded Product: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article An efficient base and H(2)O(2)free protocol for the synthesis of phenols in water and oxygen using spinel CuFe(2)O(4)magnetic nanoparticles published in 2020.0. Recommanded Product: 99-93-4, Reprint Addresses Chetia, B (corresponding author), Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

An efficient base and H(2)O(2)free protocol was used for the synthesis of phenols from boronic acids using biogenic CuFe(2)O(4)magnetic nanoparticles as catalyst at room temperature in water and oxygen. The catalyst was prepared using the flowers ofLantana camara. The size of the nanoparticles was 4.27 nm. Base free and ligand free protocol, less time, excellent yields, room temperature, biogenic synthesis of the catalyst, use of O(2)as an environmentally friendly oxidant are the advantages of the present protocol. The recyclability of the catalyst was for 5 cycles without loss of magnetic property or catalytic activity.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Chutia, R; Chetia, B or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. I found the field of Chemistry very interesting. Saw the article Synthesis, photophysical and electrochemical properties of donor-acceptor type hydrazinyl thiazolyl coumarins published in 2020, Reprint Addresses Nallagondu, CGR (corresponding author), Yogi Vemana Univ, Sch Phys Sci, Dept Chem, Kadapa 516003, Andhra Pradesh, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.

A water-mediated MCR strategy has been developed for the synthesis of donor (D)-acceptor(A) type hydrazinyl thiazolyl coumarins (HTCs) (4) in excellent isolated yields (90-98%) from a three component reaction of aromatic aldehydes/ketones (1), thiosemicarbazide (2) and 3-(2-bromoacetyl)-2H-chromen-2-one (3) catalyzed by an environmentally compatible montmorillonite (MMT) K10 clay at RT for 20-40 min. The present MCR strategy has several advantages that include its wide-spread substrate scope, eco-compatibility, short reaction times and products that do not require chromatographic purification. Besides, the method is simple to perform, it is easy to construct C-N, C=N and C-S bonds in one pot and the reaction can be scaled up to a gram level. Moreover, the catalyst can be reused 7 times without significant change of activity. The photophysical properties of the synthesized D-A type HTCs are also studied and it was noticed that the fluorescence properties can be varied with the position of electron donating group on the aromatic ring of aldehyde/ketone of HTCs. Most of the compounds exhibited bright fluorescence in chloroform (1.0 x 10(-5) M) with emission maxima ranging from 409 to 511 nm and large Stokes shifts. Further, the HOMO and LUMO energy levels of the HTCs are found in the range from -5.65 eV to -5.22 eV and -2.67 eV to -2.17 eV, respectively, and in good agreement with the reported hole transporting materials.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Godugu, K; Gundala, TR; Bodapati, R; Yadala, VDS; Loka, SS; Nallagondu, CGR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ESTERS; ACID; MECHANOCHEMISTRY; ULTRASOUND; CHALLENGES; MICROWAVE; MITSUNOBU; REAGENT; OIL, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21978270]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zheng, L; Sun, C; Xu, WH; Dushkin, AV; Polyakov, N; Su, WK; Yu, JB. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Application In Synthesis of 4′-Hydroxyacetophenone

Herein, we describe two novel strategies for the synthesis of esters, as achieved under high-speed ball-milling (HSBM) conditions at room temperature. In the presence of I-2 and KH2PO2, the reactions afford the desired esterification derivatives in 45% to 91% yields within 20 min of grinding. Meanwhile, using KI and P(OEt)(3), esterification products can be obtained in 24% to 85% yields after 60 min of grinding. In addition, the I-2/KH2PO2 protocol was successfully extended to the late-stage diversification of natural products showing the robustness of this useful approach. Further application of this method in the synthesis of inositol nicotinate was also discussed.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zheng, L; Sun, C; Xu, WH; Dushkin, AV; Polyakov, N; Su, WK; Yu, JB or concate me.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOORG CHEM published article about ALZHEIMERS-DISEASE; DONEPEZIL; TACRINE; HYBRIDS; DESIGN; E2020 in [Kuzu, Burak; Tan, Meltem; Menges, Nurettin] Van Yuzuncu Yil Univ, Pharmaceut Chem Sect, TR-65080 Van, Turkey; [Kuzu, Burak; Tan, Meltem; Menges, Nurettin] YYU TEKNOKENT, SAFF Chem Reagent R&D Lab, TR-65080 Van, Turkey; [Taslimi, Parham; Gulcin, Ilhami] Ataturk Univ, Dept Chem, TR-25240 Erzurum, Turkey; [Taspinar, Mehmet] Van Yuzuncu Yil Univ, Dept Med Biol, TR-65080 Van, Turkey in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. Structure activity relationship studies, docking studies to on X-ray crystal structure of AChE with PDB code 1B41, and adsorption, distribution, metabolism, and excretion (ADME) predictions were performed. The synthesized core skeleton was bound to important regions of the active site of AChE such as the peripheral anionic site (PAS), oxyanion hole (OH), and anionic subsite (AS). Selectivity of the reported test compounds was calculated and enzyme kinetic studies revealed that they behave as competitive inhibitors, while two of the test compounds showed noncompetitive inhibitory behavior. ADME predictions revealed that the synthesized molecules might pass through the blood brain barrier and intestinal epithelial barrier and circulate freely in the blood stream without binding to human serum albumin. While the toxicity of one compound on the WS1 (skin fibroblast) cell line was 1790 mu M, its toxicity on the SH-SY5Y (neuroblastoma) cell line was 950 mu M.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kuzu, B; Tan, M; Taslimi, P; Gulcin, I; Taspinar, M; Menges, N or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 SCI TOTAL ENVIRON published article about ACTIVITY-RELATIONSHIP QSAR; MOLECULAR-OXYGEN; OXIDATION; PHENOLS; CONTAMINANTS; DEGRADATION; MATTER; PHOTOOXYGENATION; PHOTOCHEMISTRY; DEACTIVATION in [Li, Tiantian; Huang, Yu; Zhang, Ya-nan; Zhao, Yuanhui; Li, Chao] Northeast Normal Univ, Sch Environm, State Environm Protect Key Lab Wetland Ecol & Veg, Changchun 130117, Peoples R China; [Wei, Gaoliang] Jilin Univ, Coll New Energy & Environm, Key Lab Groundwater Resources & Environm, Minist Educ, Changchun 130021, Peoples R China; [Crittenden, John C.] Georgia Inst Technol, Brook Byers Inst Sustainable Syst, Atlanta, GA 30332 USA; [Crittenden, John C.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA in 2020.0, Cited 67.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

As singlet oxygen (O-1(2)) is ubiquitous in the environment, O-1(2)-involved oxidation may play an important role in the transformation and fate of organic pollutants. Accordingly, the reaction rate constants (k(1O2)) of organic compounds with O-1(2) are important to determine the environmental fate and persistence assessment of organic pollutants. However, currently there are limited k(1O2) data available, especially for organic chemicals with different charged (deprotonated/protonated) forms. Herein three quantitative structure-activity relationship (QSAR) models (one comprehensive model and two models for neutral and deprotonated molecules) were created for predicting aqueous k(1O2) values for diversely dissociating molecules. The models include larger datasets (180 chemicals) and have wider applicability domain than previous ones. Molecular structural characteristics (only half-wave potential is present in both models) determining the O-1(2) reaction rate of neutral and deprotonated molecules vary greatly. The comparison results of predicting k(1O2) values of organic compounds at certain pH conditions show that the combination of the QSAR models for neutral and deprotonated molecules has advantages over the comprehensive QSAR model. This work is the first study to predict k(1O2) for a wide variety of neutral and deprotonated molecules and provides an important tool for assessing the fate of organic pollutants in aquatic environments.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Li, TT; Huang, Y; Wei, GL; Zhang, YN; Zhao, YH; Crittenden, JC; Li, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Recently I am researching about BRONSTED ACID; AROMATIC-SUBSTITUTION; BENZYLATION; ARENES; ETHERS; MILD; ACTIVATION; BENZENE, Saw an article supported by the Natural Sciences and Engineering Research Council (NSERC) of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC); University of AlbertaUniversity of Alberta. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ang, HT; Rygus, JPG; Hall, DG. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A general and efficient boronic acid catalyzed Friedel-Crafts alkylation of arenes with benzylic alcohols was previously developed for the construction of unsymmetrical diarylmethane products (X. Mo, J. Yakiwchuk, J. Dansereau, J. A. McCubbin and D. G. Hall, J. Am. Chem. Soc., 2015, 137, 9694). Highly electron-deficient benzylic alcohols, however, were ineffective coupling partners due to the increased difficulty of C-O bond ionization. Herein, we report the use of perfluoropinacol as an effective co-catalyst to improve the reactivity of a boronic acid catalyst in the Friedel-Crafts benzylations of electronically deactivated primary and secondary benzylic alcohols. According to spectroscopic studies, it is believed that perfluoropinacol condenses with the arylboronic acid catalyst to form a highly electrophilic and Lewis acidic boronic ester. This in situ formed species enables a more facile ionization of the benzylic alcohols likely through a mode of activation promoted by a Lewis acid assisted hydronium Bronsted acid generated from the interactions of the transient boronic ester with hexafluoroisopropanol solvent and water.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ang, HT; Rygus, JPG; Hall, DG or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4′-Hydroxyacetophenone. Klinger, GE; Zhou, YT; Hao, PC; Robbins, J; Aquilina, JM; Jackson, JE; Hegg, EL in [Klinger, Grace E.; Hegg, Eric L.] Michigan State Univ, Dept Biochem & Mol Biol, 603 Wilson Rd, E Lansing, MI 48824 USA; [Klinger, Grace E.; Zhou, Yuting; Hao, Pengchao; Robbins, Jacob; Aquilina, Jake M.; Jackson, James E.] Michigan State Univ, Dept Chem, 578 S Shaw Ln, E Lansing, MI 48824 USA; [Klinger, Grace E.; Jackson, James E.; Hegg, Eric L.] Michigan State Univ, Great Lakes Bioenergy Res Ctr, 164 Food Safety & Toxicol Bldg, E Lansing, MI 48824 USA published Biomimetic Reductive Cleavage of Keto Aryl Ether Bonds by Small-Molecule Thiols in 2019.0, Cited 29.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The nucleophilic and reductive properties of thiolates and thiols make them ideal candidates as redox mediators via the thiol/disulfide couple. One mechanism for biological lignin depolymerization entails reduction of keto aryl ether bonds by an S(N)2 mechanism with the thiol redox mediator glutathione. In this study, mimicking this chemistry in a simple protein- and metal-free process, several small organic thiols are surveyed for their ability to cleave aryl keto ethers that model the beta-O-4 linkages found in partially oxidized lignin. In polar aprotic solvents, beta-mercaptoethanol and dithiothreitol yielded up to 100 % formation of phenol and acetophenone products from 2-phenoxyacetophenone, but not from its reduced alcohol congener. The effects of reaction conditions and of substituents on the aryl rings and the keto ether linkage are assessed. These results, together with activation barriers computed by quantum chemical simulations and direct observation of the expected intermediate thioether, point to an S(N)2 mechanism. This study confirms that small organic thiols can reductively break down lignin-relevant keto aryl ether linkages.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Klinger, GE; Zhou, YT; Hao, PC; Robbins, J; Aquilina, JM; Jackson, JE; Hegg, EL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Multi-catalysis of nano-zinc oxide for bisphenol A degradation in a dielectric barrier discharge plasma system: Effect and mechanism WOS:000486133700013 published article about SYNERGETIC DEGRADATION; DBD PLASMA; WATER; PERFORMANCE; PRODUCTS in [Yan, Xin; Yi, Chengwu; Wang, Yonghui; Cao, Wudi; Mao, Danni; Ou, Qingqing; Shen, Peiyao; Wang, Huijuan] Jiangsu Univ, Sch Environm & Safety Engn, Zhenjiang 212013, Jiangsu, Peoples R China in 2020.0, Cited 28.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

As a widely used chemical material, bisphenol A (BPA) is often used to produce kinds of chemicals, which lead risk to the ecological environment and human health. Based on the multi-catalysis of the nano-ZnO and multi-effect (chemical and physical) formed in the dielectric barrier discharge plasma (DBDP) system, the synergistic elimination of the BPA in the DBDP system combined with nano-ZnO was evaluated. The obtained experimental results showed that the superior adding amount of the nano-ZnO was 50 mg/L and the synergistic system on the condition had the best effect for the BPA degradation (85.4%), which was 17% higher than that in the sole DBDP system. When O-2 was bubbled into the reaction system, the degradation efficiency of the BPA in the synergistic system reached 100% after 20 min treatment. Compared with the alkaline solution, the acidic and weakly acidic solution could obtain higher treatment efficiency. (OH)-O-center dot and O-2(-) had a vital role for the BPA elimination in the synergistic system. The intermediate products detected by LC-MS included 4-cumylphenol, 4-isopropenylphenol, 4-tert-butylphenol, propiophenone, 1-(4-hydroxyphenyl) ethanone, tert-butylbenzene, benzoquinone and 1, 4-dihydroxybenzene.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yan, X; Yi, CW; Wang, YH; Cao, WD; Mao, DN; Ou, QQ; Shen, PY; Wang, HJ or concate me.. SDS of cas: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Growth Kinetics, Metabolites Production and Expression Profiling of Picrosides Biosynthetic Pathway Genes in Friable Callus Culture ofPicrorhiza kurroaRoyle ex Benth WOS:000553276000002 published article about PLANT-PICRORHIZA-KURROA; ANTIOXIDANT ACTIVITY; MEDICINAL HERB; SECONDARY METABOLITES; CONSERVATION; REGENERATION; ENHANCEMENT in [Partap, Mahinder; Kumar, Pankaj; Ashrita; Warghat, Ashish R.] CSIR, Biotechnol Div, Cell & Tissue Engn Lab, Inst Himalayan Bioresource Technol, Palampur 176061, Himachal Prades, India; [Partap, Mahinder; Ashrita; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res, New Delhi, India; [Kumar, Pawan; Kumar, Dinesh] CSIR, Nat Prod Chem & Proc Dev Div, Inst Himalayan Bioresource Technol, Palampur 176061, Himachal Prades, India in 2020.0, Cited 41.0. Product Details of 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The rising demand for picrosides commercially and over-exploitation ofPicrorhiza kurroafrom natural habitat has to initiate alternative strategies for sustainable production of metabolites. In the present research, wild leaf explant ofP. kurroawas used to produce friable callus under different culture condition, i.e., dark and light with two temperature variants (15 degrees C and 25 degrees C). Afterward, callus cell lines were screened based on growth biomass and metabolites content accumulation. The results revealed, maximum callus growth index along with antioxidant potential (IC50-40.88 mu g/mL) and total phenol content (41.35 mu g/mg) were observed under dark 25 degrees C. However, under light 15 degrees C, highest accumulation of picroside II (0.58 mu g/mg), cinnamic acid (0.15 mu g/mg),p-hydroxy acetophenone (0.30 mu g/mg), total flavonoids (77.30 mu g/mg), nitrogen (7.06%), carbohydrates (18.03%), and protein (44.12%) were detected. Major reported metabolite in callus was picroside I (1.63 mu g/mg) under dark 15 degrees C. For the first time, picroside III content (range 0.15-0.56 mu g/mg) was also detected and quantified in leaf-derived calli. Expression profiling of picroside biosynthetic pathway genes showed a positive correlation with the observed metabolites. Furthermore, an optimized protocol of metabolites enriched callus biomass could be used as potential strategy for sustainable production of picrosides at commercial scale.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Partap, M; Kumar, P; Ashrita; Kumar, P; Kumar, D; Warghat, AR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles