Category: 99-93-4

Safety of 4′-Hydroxyacetophenone. Recently I am researching about ACTIVATION; RHODIUM; AIR; FUNCTIONALIZATION; DERIVATIVES; BONDS, Saw an article supported by the National NSF of ChinaNational Natural Science Foundation of China (NSFC) [21432005, 21672154, 21871193]; Comprehensive Training Platform of Specialized Laboratory, College of Chemistry, Sichuan University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, LQ; Wang, YB; Shi, Y; Wu, YM; Lan, JB; Ma, WX; You, JS. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

An urgent yet challenging task is to overcome the limitations in substrate scope and regio- and chemoselectivity in the oxidative couplings between two arenes for the construction of unsymmetrical 2,2′-difunctional biaryls with diverse application requirements. In this work, a co-oxidant-free Rh(I)/Zn(NTf2)(2)/air catalytic system has been developed for dual chelation-assisted oxidative C-H/C-H cross-couplings between two anilines, between two phenols, and between phenols and anilines, which enables rapid assembly of rich libraries of 2,2′-bianilines, 2,2′-biphenols, and 2′-aminobiphenyl-2-ols. This protocol features air as the sole oxidant, complete regioselectivity, high chemoselectivity, low molar ratio of substrates (even 1:1), convenient operation, and scale-up synthesis. The established catalytic system is tolerant of the substrates having both electron-donating and electron-withdrawing substituents at different positions of the aryl ring. This work further discloses that the chemoselectivity of cross-coupling over homocoupling mainly relies on a suitable combination of two directing groups (i.e., a pair of strongly and weakly coordinating directing groups) rather than the electronically distinct properties between two substrates, which provides an inspiration for designing the matching directing group pair for the dual chelation-assisted oxidative Ar-H/Ar-H cross-couplings. Thus, this strategy allows the highly chemoselective cross-coupling between electronically similar coupling partners, which represents a challenging task in the oxidative Ar-H/Ar-H cross-coupling reactions.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhang, LQ; Wang, YB; Shi, Y; Wu, YM; Lan, JB; Ma, WX; You, JS or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of the impurity F of salbutamol WOS:000541362600001 published article about SULFATE in [Song, Shu-Lian; Lian, Cheng-Xi; Chen, Li-Ping; Huang, Long-Liang] Qingdao Univ Sci & Technol, Coll Chem Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China in 2020.0, Cited 8.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2% total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations. [GRAPHICS] .

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Song, SL; Lian, CX; Chen, LP; Huang, LL or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 SYNLETT published article about AEROBIC OXIDATIVE HYDROXYLATION; HIGHLY EFFICIENT CONVERSION; VISIBLE-LIGHT; HETEROGENEOUS CATALYST; HYDROGEN-PEROXIDE; BORONATE ESTERS; PHENOLS; MILD; CHITOSAN; NANOPARTICLES in [Shin, Eun-Jae; Kwon, Gyu-Tae; Kim, Seung-Hoi] Dankook Univ, Dept Chem, 119 Dandaero, Cheonan 31116, South Korea in 2019.0, Cited 56.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. HPLC of Formula: C8H8O2

The oxidative hydroxylation of arylboronic acids to the corresponding phenolic compounds under metal- and base-free aerobic conditions is successfully demonstrated on a greener media. Hydrogen peroxide, as an eco-friendly oxidant, is compatible with green mediates room-temperature ionic liquids (RTIL)s, providing hydroxylation products of arylboronic acids in an efficient manner. The RTIL support is particularly interesting for its reusability.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Shin, EJ; Kwon, GT; Kim, SH or concate me.. Name: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A one-pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents WOS:000502519700001 published article about BIOLOGICAL EVALUATION; PYRAZOLE; GREEN; CHLOROTRIMETHYLSILANE in [Desai, Nisheeth C.; Joshi, Surbhi B.; Jadeja, Krunalsinh A.] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem DST FIST Sponsored & UGC NON SAP, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India in 2020.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Quality Control of 4′-Hydroxyacetophenone

A convenient synthesis of pyrimidinthiones was carried out in presence of thiourea and easily available catalyst sulfamic acid (2a-t). One-pot Biginelli reaction is very important due to the use of simple and readily available chemicals, less reaction time, economically friendly, and furnishing good yield. Structures of the synthesized compounds are characterized by spectral techniques like IR, H-1-NMR, C-13-NMR, and LC-MS. Synthesized compounds were studied for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, and S. aureus, S. pyogenes) and fungi (C. albicans, A. niger, and A. clavatus) using serial dilution method.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Desai, NC; Joshi, SB; Jadeja, KA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of coumarins modified with cobalt bis (1,2-dicarbolide) and closo-dodecaborate boron clusters WOS:000548959300011 published article about OXONIUM DERIVATIVES; CARBORANE; DESIGN; ANION in [Kosenko, Irina; Laskova, Julia; Kozlova, Alexandra; Semioshkin, Andrey; Bregadze, Vladimir, I] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilova Str 28, Moscow 119991, Russia in 2020.0, Cited 39.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Quality Control of 4′-Hydroxyacetophenone

Synthesis and characterization of novel coumarins containing carborane units were described. The breakdown reactions of cyclic oxonium derivatives of cobalt bis (1,2-dicarbollide) and closo-dodecaborate anions with a series of 7-hydroxy-3-substituted coumarins led to conjugates attached via C-7 position of the coumarin unit. The corresponding reactions of cobalt bis (1,2-dicarbollide) anion with 3-(4-hydroxybenzoyl)-7-methoxy-2H-chromen-2-one led to conjugates attached via C-3 position. Novel conjugates were isolated in the form of alkali metal salts. Therefore, these conjugates are of interest for the fluorescent study in aqua media. (C) 2020 Elsevier B.V. All rights reserved.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kosenko, I; Laskova, J; Kozlova, A; Semioshkin, A; Bregadze, VI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic Asymmetric Intermolecular Radical Aminotrifluoromethylation of Alkenes with Hydrazines by Cu(I)/CPA Cooperative Catalysis WOS:000573846600001 published article about UNACTIVATED ALKENES; INTRAMOLECULAR AMINOTRIFLUOROMETHYLATION; TRIFLUOROMETHYLATION; OLEFINS; AMINOPERFLUOROALKYLATION; AMINODIFLUOROMETHYLATION; DIFUNCTIONALIZATION; FUNCTIONALIZATION; FLUORINATION in [Wang, Zhe; Shi, Zhichao; Zhan, Feng; Lin, Jin-Shun] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; [Wang, Zhe; Shi, Zhichao; Zhan, Feng; Lin, Jin-Shun; Jiang, Yuyang] Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen 518055, Peoples R China; [Cheng, Jiang-Tao; Wang, Na; Jiang, Sheng-Peng; Liu, Xin-Yuan] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; [Cheng, Jiang-Tao; Wang, Na; Jiang, Sheng-Peng; Liu, Xin-Yuan] Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China; [Jiang, Yuyang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China in 2021.0, Cited 77.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone

A first catalytic enantioselective intermolecular radical aminotrifluoromethylation of alkene with hydrazine and Togni’s reagent by Cu(I)/CPA cooperative catalysis has been reported, accessing diversely substituted CF3-containing enantioenriched diarylmethylamines bearing an alpha-tertiary stereocenter with high enantioselectivity and excellent chemoselectivity. The highly asymmetric induction of C-N bond formation between hydrazine and the carbocation intermediate was achieved by using a CPA catalystviahydrogen-bonding and ion pair interaction.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wang, Z; Cheng, JT; Shi, ZC; Wang, N; Zhan, F; Jiang, SP; Lin, JS; Jiang, YY; Liu, XY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 BIOORG MED CHEM LETT published article about BIOLOGICAL EVALUATION; TUBULIN INHIBITORS; ANTICANCER AGENTS; COMBRETASTATIN ANALOGS; COLCHICINE SITE; BINDING; DERIVATIVES; PHOSPHATE; DESIGN; CYTOTOXICITY in [Dwivedi, Ashish Ranjan; Kumar, Vijay; Kaur, Harmeet; Kumar, Naveen; Poduri, Ramarao; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda 151001, Punjab, India; [Yadav, Ravi Prakash; Baranwal, Somesh] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Microbiol, Bathinda 151001, Punjab, India; [Kumar, Vinod] Cent Univ Punjab, Lab Organ & Med Chem, Dept Chem, Bathinda 151001, Punjab, India in 2020.0, Cited 47.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 mu M, 4.78 mu M and 4.23 mu M, HK-10 showed IC50 values of 0.81 mu M, 5.89 mu M, 4.96 mu M and HK-13 showed IC50 values 3.24 mu M, 4.93 mu M and 4.73 mu M against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 mu M against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 99-93-4. Authors Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS in WILEY published article about in [Telu, Jhonsee Rani; Kuntala, Naveen; Anireddy, Jaya Shree] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, Inst Sci & Technol, Hyderabad 500085, India; [Kankanala, Kavitha; Pal, Sarbani] MNR Degree & PG Coll, Dept Chem, Hyderabad, India; [Banothu, Venkanna] JNTUH, IST, Ctr Biotechnol, Hyderabad, India in 2021.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We describe the synthesis, characterization, and in vitro antibacterial evaluation of a library of novel compounds based on 1,2,3-triazolo phosphonate framework along with the evaluation of DNA gyrase inhibitory potential of a promising molecule in silico. Preparation of these compounds was carried out via a multistep sequence comprising of the Abramov reaction followed by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key steps. Various alpha-hydroxyphosphonate derivatives containing either a secondary or tertiary alcohol at the alpha position were prepared. When screened for their antibacterial activities in vitro using a Gram-positive (Staphylococcus aureus) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) strains, majority of these derivatives exhibited reasonable to good effects with the analogue 5k being active against all the strains. The SAR analysis indicated that the activity was influenced by the position of the alpha-hydroxyphosphonate moiety as well as the substituent present on the benzene ring attached to the 1,2,3-triazole ring. Moreover, the compound 5k showed strong interactions with the DNA active site when docked into the DNA gyrase in silico. Thus, the 1,2,3-triazolo phosphonate derivative 5k appeared to be a novel and promising hit molecule that deserves further study as a potential antibacterial agent.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2020.0 RUSS J APPL CHEM+ published article about ANTIOXIDANTS; MECHANISMS; KINETICS; ACIDS; FOOD in [Belaya, N. I.] Donetsk Natl Univ, UA-83001 Donetsk, Ukraine in 2020.0, Cited 15.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Using multiple linear regression analysis, a relationship has been established between the antiradical activity of various classes of natural phenols and descriptors of their electronic structure in the form of semiempirical linear one- and two-factor equations. The predictive ability of the obtained model in the control sample was estimated; the average approximation error was no more than 6.5%. The obtained descriptor-activity relationship is the basis for predicting the antiradical properties of natural phenols of various structures in polar media.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Belaya, NI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 CHEMISTRYSELECT published article about COPPER-CATALYZED HYDROXYLATION; ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; BORONIC ACIDS; HETEROGENEOUS CATALYST; ORGANOCATALYTIC OXIDATION; ARYL HALIDES; NANOPARTICLES; MILD; ALDEHYDES in [Gujjarappa, Raghuram; Vodnala, Nagaraju; Malakar, Chandi C.] Natl Inst Technol Manipur, Dept Chem, Imphal 795004, Manipur, India; [Garg, Aakriti; Gupta, Sreya] NIPER, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India; [Hazra, Chinmoy K.] Indian Inst Technol Delhi, Dept Chem, Hauz Khas, New Delhi 110016, India in 2020, Cited 80. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

An efficient amino-acid-mediated ipso-hydroxylation of arylboronic acids, aryl boronate esters and aryl trifluoroborates to aryl alcohols has been described. The current protocol was realized by using sub-stoichiometric amount of l-histidine in presence of triethylamine under aerobic conditions in DMF as solvent. This amino-acid-mediated process provides an alternative route for the hydroxylation of organoborons through in situ generation of hydrogen peroxide. The present protocol explores the synthetic utility of amino acids as organocatalysts for the preparation of aryl alcohols. It was observed that l-histidine plays an important role for the conversion of aerial oxygen in to hydrogen peroxide via thermal excitation process followed by thermal degradation of Et3N. The developed approach holds good for a wide range of compounds with excellent yields and competent functional group tolerance.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gujjarappa, R; Vodnala, N; Garg, A; Hazra, CK; Gupta, S; Malakar, CC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles