Category: 99-93-4

Authors Ghosh, P; Maity, T; Biswas, S; Debnath, R; Koner, S in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Ghosh, Pameli; Maity, Tanmoy; Debnath, Rakesh; Koner, Subratanath] Jadavpur Univ, Dept Chem, Kolkata 700032, India; [Maity, Tanmoy] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India; [Biswas, Saptarshi] Katwa Coll, Katwa 713130, W Bengal, India in 2021, Cited 120. Application In Synthesis of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Hydrothermal treatment of gadolinium nitrate and 2,6-naphthalenedicarboxylic acid (H2NDC) afforded a new metal-organic framework compound, {[Gd-4(NDC)(6)(H2O)(6)]center dot 2H(2)O}n(1). Compound 1 has been characterized by single-crystal X-ray crystallography, elemental analysis, FT-IR spectroscopy, therrmogravimetric analysis (TGA) and powder X-ray diffraction analysis. It is crystallized in the monoclinic system with the P2(1)/n space group. Four crystallographically distinct Gd (III) centres are interconnected with each other through bridged carboxylato oxygen atoms and water molecules to form tetranuclear secondary building units, which are further connected through the carboxylato ligand and the network propagates along the crystallographic ac plane to form a 2D structure. Subsequent reinforcement from the remaining carboxylato oxygen atoms gives rise to a robust 3D framework structure. Thermogravimetric analysis demonstrates that compound 1 is fairly stable after dehydration under a nitrogen atmosphere. Notably, compound 1 is capable of catalyzing the O-arylation reaction efficiently between substituted phenols and bromoarene under heterogeneous conditions at 80 degrees C to afford unsymmetrical diarylethers. (C) 2020 Elsevier Ltd. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ghosh, P; Maity, T; Biswas, S; Debnath, R; Koner, S or concate me.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Waheed, M; Ahmed, N; Alsharif, MA; Alahmdi, MI; Mukhtar, S in WILEY-V C H VERLAG GMBH published article about ONE-POT SYNTHESIS; CARBONYL-COMPOUNDS; ALKENES; REGENERATION; AMINATION; GREEN; DIHYDROXYLATION; DEPROTECTION; CATALYSTS; NITRONES in [Waheed, Mohd; Ahmed, Naseem] Indian Inst Technol Roorkee, Dept Chem, Roorkee, Uttar Pradesh, India; [Alsharif, Meshari A.; Alahmdi, Mohammed Issa; Mukhtar, Sayeed] Univ Tabuk, Fac Sci, Dept Chem, Tabuk 71491, Saudi Arabia in 2019.0, Cited 57.0. Name: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Developed a novel K2S2O8-mediated methodology for the oxidative deoximation of flavanone and chalcone oximes to synthesize the corresponding flavanones and chalconesin good to excellent yields (92-70%). Our methodology is successfully applied for the deoximation of flavanone oximes, chalcone oximes, ketoximes and aldoximes. This methodology is equally useful for the hindered and functionalized aldoximes and ketoximes. Mild reaction condition, shorter reaction time, high yields, easy work-up and purification of the products are the key advantages of the methodology.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Waheed, M; Ahmed, N; Alsharif, MA; Alahmdi, MI; Mukhtar, S or concate me.. Name: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and Biological Activity of Ethyl 2-[8-Arylmethylidenehydrazino-3-Methyl-7-(1-Oxothietan-3-YL)Xanth-1-YL]Acetates WOS:000541181100003 published article about DERIVATIVES in [Gurevich, K. G.] AI Evdokimov Moscow State Univ Med & Dent, 20-1 Delegatskaya St, Moscow 127473, Russia; [Urakov, A. L.; Bashirova, L., I] Minist Hlth RF, Izhevsk State Med Acad, 281 Kommunarov St, Izhevsk 426034, Udmurtia, Russia; [Klen, E. E.; Samorodov, A., V; Nikitina, I. L.; Khaliullin, F. A.; Nebogatova, V. A.; Makarova, N. N.; Shepilova, S. O.; Khalimov, A. R.] Bashkir State Med Univ, Minist Hlth RF, 3 Lenin St, Ufa 450008, Bashkortostan, Russia in 2020.0, Cited 11.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Ethyl 2-[8-Arylmethylidenehydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetates (IV) were synthesized via reactions of ethyl 2-[8-hydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetic acid (III) with various benzaldehydes and acetophenones. The structures of the compounds were elucidated using IR and NMR spectroscopy and elemental analysis. The antiplatelet, anticoagulation, antioxidant, and anti-inflammatory activities were assessedin vitroand in laboratory animals to identify promising compounds exhibiting antiplatelet (hydrazoneIVd) and antioxidant properties (hydrazoneIVb). BothIVbandIVdaccording toin silicocalculations were characterized by the absence of toxic risks (mutagenicity, oncogenicity, reproductive toxicity, local irritation) and had acceptable topological polar surface area so that they were promising.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gurevich, KG; Urakov, AL; Klen, EE; Samorodov, AV; Nikitina, IL; Khaliullin, FA; Nebogatova, VA; Makarova, NN; Shepilova, SO; Bashirova, LI; Khalimov, AR or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 SCI TOTAL ENVIRON published article about PERSISTENT FREE-RADICALS; LITTER DECOMPOSITION; ARABLE SOILS; DEGRADATION; CARBON; STABILIZATION; FOREST; PLANT; BIOMARKERS; FRACTIONS in [Li, Fangfang; Chang, Zhaofeng; Khaing, Kaythi; Zhou, Yuwei; Liang, Ni; Zhou, Dandan; Pan, Bo] Kunming Univ Sci & Technol, Fac Environm Sci & Engn, Kunming 650500, Yunnan, Peoples R China; [Li, Fangfang; Chang, Zhaofeng; Khaing, Kaythi; Zhou, Yuwei; Liang, Ni; Zhou, Dandan; Pan, Bo] Yunnan Prov Key Lab Carbon Sequestrat & Pollut Co, Kunming 650500, Yunnan, Peoples R China; [Steinberg, Christian E. W.] Humboldt Univ, Lab Freshwater & Stress Ecol, Arboretum, Spathstr 80-81, D-12437 Berlin, Germany; [Zhao, Haiyun] Dali Inst Food Control, Dali 671000, Peoples R China in 2019.0, Cited 43.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone

The formation of organo-mineral complexes is essential in organic matter (OM) stabilization. However, limited studies have been conducted to systematically examine the mineral influence on the decomposition of plant residuals at a molecular level. In this study, pine needles and chestnut leaves were mixed with kaolinite at the weight ratio of 5:1. The controls were plant tissues without kaolinite. All the samples were incubated in the laboratory for one year. Molecular markers, including lignin-derived phenols (e.g. Vanilly units, syringyl units and cinnamyl units) and solvent-extractable lipids (e.g. n-alkanoic acid, n-alkanols and n-alkanes), were analyzed. The concentrations of lignin-derived phenols and lipid compounds were higher in the presence of kaolinite than without kaolinite. Lower degradation indexes, such as (Ad/Al) V (ratio of vanillic acid to vanillin) and CPI (carbon preference index of n-alkanoic acid and n-alkanes), were found in the kaolinite system. These results indicate that kaolinite reduced the OMdecomposition. The addition of kaolinite also stabilized some carbohydrates from plants. Furthermore, the degradation of OM led to the generation of persistent free radicals, indicated by electron paramagnetic resonance (EPR) signals. The EPR signals were higher with than without kaolinite. Wehypothesize that the adsorption of semiquinone or quinone radicals on kaolinite may limit their reaction with other OM moieties and thus extended their lifetimes. In addition to embedding OM in soil aggregates, our results provide direct evidence of another mineral protective mechanism of soil OM. (C) 2018 Elsevier B.V. All rights reserved.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Li, FF; Chang, ZF; Khaing, K; Zhou, YW; Zhao, HY; Liang, N; Zhou, DD; Pan, B; Steinberg, CEW or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about STAPHYLOCOCCUS-AUREUS MRSA; METHICILLIN-RESISTANT; ANALOGS, Saw an article supported by the . Published in SPRINGER in DORDRECHT ,Authors: Narwal, S; Kumar, S; Verma, PK. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Product Details of 99-93-4

Chalcones are open-chain flavonoids which contains two aromatic rings are joined by 3-carbons alpha-, beta-unsaturated carbonyl chain. The, beta-unsaturated ketonic group which is liable for the antimicrobial activity of the chalcone is additionally of vast use in further chemical modification into a variety of heterocyclic compounds. A new series of chalcone derivatives was synthesized and characterized by spectral analysis (IR, 1H-NMR, 13C-NMR, MS and elemental analysis) and evaluated for its in vitro antimicrobial activity against bacterial (Gram negative and Gram positive) and fungal strains using tube dilution method. The antimicrobial screening results revealed that some compounds of the series 1 (MICpa = 1.16 mu M), 3 (MICbs = 1.82 mu M), 6 (MICan = 2.09 mu M), 8 (MICec and se = 0.94 and 1.88 mu M) and 17 (MICsa and ca = 0.91 and 1.81 mu M) showed the most promising antimicrobial activity against both Gram-positive as well as Gram-negative bacterial and fungal strains, and comparable to the standard drugs used as positive control (cefadroxil and fluconazole).

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Narwal, S; Kumar, S; Verma, PK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4′-Hydroxyacetophenone. Yuan, ZB; Zeng, YY; Feng, ZW; Guan, Z; Lin, AJ; Yao, HQ in [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, State Key Lab Nat Med SKLNM, Sch Pharm, Nanjing 210009, Peoples R China; [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, Dept Med Chem, Sch Pharm, Nanjing 210009, Peoples R China published Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes in 2020.0, Cited 52.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Transition-metal-catalyzed tandem Heck/carbonylation reaction has emerged as a powerful tool for the synthesis of structurally diverse carbonyl molecules, as well as natural products and pharmaceuticals. However, the asymmetric version was rarely reported, and remains a challenging topic. Herein, we describe a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. Alcohols, phenols and amines are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asymmetric tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohols, phenols and amines.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yuan, ZB; Zeng, YY; Feng, ZW; Guan, Z; Lin, AJ; Yao, HQ or concate me.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 99-93-4. Recently I am researching about CYSTATHIONINE-BETA-SYNTHASE; PROTEIN SIDE-CHAIN; HYDROGEN-SULFIDE; H2S; ANGIOGENESIS; PARAMETERS; INSIGHTS; POTENT; AMBER, Saw an article supported by the Swiss Krebsliga; Novartis Foundation (Switzerland)Novartis. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bantzi, M; Augsburger, F; Loup, J; Berset, Y; Vasilakaki, S; Myrianthopoulos, V; Mikros, E; Szabo, C; Bochet, CG. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

The enzyme 3-mercaptopyruvate sulfurtransferase (3-MST) is one of the more recently identified mammalian sources of H2S. A recent study identified several novel 3-MST inhibitors with micromolar potency. Among those, (2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one) or HMPSNE was found to be the most potent and selective. We now took the central core of this compound and modified the pyrimidone and the arylketone sides independently. A 63-compound library was synthesized; compounds were tested for H2S generation from recombinant 3-MST in vitro. Active compounds were subsequently tested to elucidate their potency and selectivity. Computer modeling studies have delineated some of the key structural features necessary for binding to the 3-MST’s active site. Six novel 3-MST inhibitors were tested in cell-based assays: they exerted inhibitory effects in murine MC38 and CT26 colon cancer cell proliferation; the antiproliferative effect of the compound with the highest potency and best cell-based activity (1b) was also confirmed on the growth of MC38 tumors in mice.

Recommanded Product: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bantzi, M; Augsburger, F; Loup, J; Berset, Y; Vasilakaki, S; Myrianthopoulos, V; Mikros, E; Szabo, C; Bochet, CG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2019.0 EUR J MED CHEM published article about ALZHEIMERS-DISEASE; A-BETA; TC-99M/RE COMPLEXES; PROBES; PET; RADIOLIGAND; TECHNETIUM; CHALCONE; RE in [Molavipordanjani, Sajjad; Noaparast, Zohreh; Hosseinimehr, Seyed Jalal] Mazandaran Univ Med Sci, Dept Radiopharmacy, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Molavipordanjani, Sajjad] Mazandaran Univ Med Sci, Student Res Comm, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Dept Med Chem, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Mardanshahi, Alireza] Mazandaran Univ Med Sci, Dept Radiol, Fac Med, Sari, Iran; [Amiri, Fereshteh Talebpour] Mazandaran Univ Med Sci, Dept Anat, Fac Med, Sari, Iran in 2019.0, Cited 37.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with Tc-99m radionuclide at high radiochemical purity using fac-(Tc-99(m)(CO)(3)(H2O)(3)](+) synthon. [Tc-99m]7a and [Tc-99m]7b were evaluated as single photon emission computed tomography (SPECT) imaging agents for A beta plaque in AD. [Tc-99m]7a and (Tc-99m]7b exhibited suitable affinity toward A beta aggregates with IC50 values of 33.2 and 102.5 nM, respectively. The IC50 value of these radiotracers depends on the length of the spacer (alkyl chain). In biodistribution study, these complexes showed good initial brain uptakes (0.78 and 0.86% ID/g at 2 min post-injection) and fast blood clearance. Autoradiography results confirmed that these small Tc-99m complexes (Mw about 600 Da) can bind to A beta plaques in the brain sections of the rat AD model. Histopathological staining with Congo red approved the presence of A beta plaques in these brain sections. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Molavipordanjani, S; Emami, S; Mardanshahi, A; Amiri, FT; Noaparast, Z; Hosseinimehr, SJ or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. I found the field of Chemistry very interesting. Saw the article Synthesis and antibacterial activity of chalcone derivatives containing thioether triazole published in 2020.0, Reprint Addresses Xue, W (corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China.; Wang, H (corresponding author), Hubei Acad Agr Sci, Inst Plant Protect & Soil Sci, Wuhan 430064, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.

The infection of Xanthomonas oryzae pv. Oryzae (Xoo), Ralstonia solanacearum (Rs), and Xanthomonas axonopodis pv. Citri (Xac) has become a major problem in agricultural production. In this study, a series of novel chalcone derivatives containing thioether triazoles were designed and synthesized. The structures of the novel compounds were systematically characterized via H-1-NMR, C-13-NMR, and HRMS. Moreover, the antibacterial activity results showed that E-10, E-11, E-15, and E-16 have adequate antibacterial activities against Xoo, Rs, and Xac. Among the different compounds, E-15 exhibited remarkable inhibitory effect against Xac with an EC50 of 9.1 mu g.mL(-1), which was better than that of commercial agent bismerthiazol (54.9 mu g.mL(-1)). In addition, the possible antibacterial mechanism of the target compound E-15 against Xac was studied via scanning electron microscopy (SEM).

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Chen, Y; Li, P; Chen, M; He, J; Su, SJ; He, M; Wang, H; Xue, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Khakyzadeh, V; Rostami, A; Veisi, H; Shaghasemi, BS; Reimhult, E; Luque, R; Xia, YZ; Darvishi, S in ROYAL SOC CHEMISTRY published article about ONE-POT SYNTHESIS; MICHAEL-CYCLOCONDENSATION REACTION; ARYL BORONIC ACIDS; COUPLING REACTIONS; LIGAND-FREE; H BOND; TRIPHENYLTIN CHLORIDE; EFFICIENT CATALYST; ODORLESS SYNTHESIS; ARYLBORONIC ACIDS in [Khakyzadeh, Vahid; Darvishi, Sima] KN Toosi Univ Technol, Dept Chem, POB 16315-1618, Tehran 15418, Iran; [Rostami, Abed] Kurdistan Univ Med Sci, Food & Drug, Sanandaj, Iran; [Veisi, Hojat] Payame Noor Univ, Dept Chem, Tehran, Iran; [Shaghasemi, Behzad Shirmardi; Reimhult, Erik] Univ Nat Resources & Life Sci, Dept Nanobiotechnol, Inst Biol Inspired Mat, Muthgasse 11, A-1190 Vienna, Austria; [Luque, Rafael] Univ Cordoba, Dept Quim Organ, Edif Marie Curie,Ctra Nnal 4-A,Km 396, E-14014 Cordoba, Spain; [Luque, Rafael] Peoples Friendship Univ Russia, RUDN Univ, 6 Miklukho Maklaya Str, Moscow 117198, Russia; [Xia, Yuanzhi] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China in 2019.0, Cited 76.0. Application In Synthesis of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A dual-metal catalysis system including a newly prepared nanoparticle [SiO2@ organic-linker(OL)@ Pd(II)] and CuI was introduced with ultra-high catalytic activity (high turnover number (TON), up to 19 000) to a one-pot and odorless synthesis of unsymmetrical aryl sulfides by crossover C-S bond formation. The reaction proceeds via C-O bond activation of phenols and direct C-S bond formation in the presence of S8 as an oddorless sulfur source and aryl boronic acids under mild conditions (room temperature). The catalyst could be recycled up to five times without an obvious change in its activity.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Khakyzadeh, V; Rostami, A; Veisi, H; Shaghasemi, BS; Reimhult, E; Luque, R; Xia, YZ; Darvishi, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles