Category: 99-93-4

Authors Gogoi, P; Shakya, A; Ghosh, SK; Gogoi, N; Gahtori, P; Singh, N; Bhattacharyya, DR; Singh, UP; Bhat, HR in WILEY published article about PLASMODIUM-FALCIPARUM; MALARIA PARASITES; CYANURIC CHLORIDE; DOCKING; RESISTANCE; DESIGN in [Gogoi, Pinku; Shakya, Anshul; Ghosh, Surajit K.; Gogoi, Neelutpal; Bhat, Hans R.] Dibrugarh Univ, Dept Pharmaceut Sci, Dibrugarh 786004, Assam, India; [Gahtori, Prashant; Singh, Nardev] Graph Era Hill Univ, Sch Pharm, Dehra Dun, Uttarakhand, India; [Bhattacharyya, Dibya R.] Indian Council Med Res ICMR, Reg Med Res Ctr, Dibrugarh, Assam, India; [Singh, Udaya P.] Sam Higginbottom Univ Agr Technol & Sci, Dept Pharmaceut Sci, Drug Design & Discovery Lab, Allahabad, Uttar Pradesh, India in 2021.0, Cited 25.0. Computed Properties of C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Malaria continues to become a major global health problem, particularly in Sub-Saharan Africa, Asia, and Latin America. The widespread emergence of resistance to first-line drugs has further bolstered an urgent need for a new and cost-effective antimalarial(s). Thus, the present study enumerates the synthesis of novel hybrid dimethoxy pyrazole 1,3,5-triazine derivatives 7(a-j) and their in silico results short-listed three compounds with good binding energies and dock scores. Docking analysis shows that hydrogen-bonding predominates and typically involves key residues, such as Asp54, Tyr170, Ile164, and Arg122. The in vitro antimalarial evaluation of three top-ranked compounds (7e, 7g, and 7h) showed half-maximal inhibitory concentration values range from 53.85 to 100 mu g/ml against chloroquine-sensitive strain 3D7 of Plasmodium falciparum. Compound 7e may be utilized as a lead for further optimization work in drug discovery due to good antimalarial activity.

Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gogoi, P; Shakya, A; Ghosh, SK; Gogoi, N; Gahtori, P; Singh, N; Bhattacharyya, DR; Singh, UP; Bhat, HR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Inaloo, ID; Majnooni, S in [Inaloo, Iman Dindarloo] Shiraz Univ, Coll Sci, Chem Dept, Shiraz 7194684795, Iran; [Majnooni, Sahar] Univ Isfahan, Chem Dept, Esfahan 8174673441, Iran published A Fe3O4@SiO2/Schiff Base/Pd Complex as an Efficient Heterogeneous and Recyclable Nanocatalyst for One-Pot Domino Synthesis of Carbamates and Unsymmetrical Ureas in 2019.0, Cited 165.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4@SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Inaloo, ID; Majnooni, S or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein WOS:000464767700013 published article about STRUCTURAL-CHARACTERIZATION; PROVIRAL DNA; IDENTIFICATION; INHIBITION; BINDING; RECOGNITION; COMPLEX; TAR in [Mori, Mattia; Lang, Maria Chiara Dasso; Palombi, Nastasja; Friggeri, Laura; Botta, Maurizio] Univ Siena, Dept Excellence 2018 2022, Dept Biotechnol Chem & Pharm, Via Aldo Moro 2, I-53100 Siena, Italy; [Saladini, Francesco; Giannini, Alessia; Zazzi, Maurizio] Univ Siena, Dept Med Biotechnol, Viale Mario Bracci 16, I-53100 Siena, Italy; [Kovalenko, Lesia; Mely, Yves] Univ Strasbourg, CNRS, Fac Pharm, Lab Bioimagerie & Pathol,UMR 7021, 74 Route Rhin, F-67401 Illkirch Graffenstaden, France; [De Forni, Davide; Poddesu, Barbara] ViroStat Srl, Viale Umberto I 46, I-07100 Sassari, Italy; [Malancona, Savina; Summa, Vincenzo] IRBM Sci Pk SpA, Via Pontina Km 30-600, I-00071 Pomezia, RM, Italy; [Botta, Maurizio] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, BioLife Sci Bldg,Suite 333,1900 N 12th St, Philadelphia, PA 19122 USA; [Botta, Maurizio] Lead Discovery Siena Srl, Vittorio Alfieri 31, I-53019 Castelnuovo, Berardenga, Italy in 2019.0, Cited 28.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the molecule is deputed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by molecular dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds 6 and 13 showed no cytotoxicity, thus becoming valuable leads for further investigations.

Quality Control of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Mori, M; Lang, MCD; Saladini, F; Palombi, N; Kovalenko, L; De Forni, D; Poddesu, B; Friggeri, L; Giannini, A; Malancona, S; Summa, V; Zazzi, M; Mely, Y; Botta, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Beckmann rearrangement: Thiamine hydrochloride as a remarkable catalyst for one-pot synthesis of amides from ketones WOS:000530096600002 published article about ONE-STEP SYNTHESIS; CYCLOHEXANONE-OXIME; SOLVENT-FREE; ORGANIC-SYNTHESIS; NONCATALYTIC BECKMANN; SUPERCRITICAL WATER; EPSILON-CAPROLACTAM; EFFICIENT PROMOTER; REUSABLE CATALYST; IONIC LIQUIDS in [Mahajan, Sheena; Slathia, Nancy; Kapoor, Kamal K.] Univ Jammu, Dept Chem, Jammu 180006, India in 2020.0, Cited 74.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Computed Properties of C8H8O2

Thiamine hydrochloride catalyzed synthesis of amides from ketones including 3-acetyl coumarin via Beckmann rearrangement has been reported. The reaction is believed to involve oxime formation, cleavage of C-C bond followed by C-N bond formation in one-pot. Thiamine hydrochloride is stable, cheap, easy to handle and environmentally friendly. (C) 2020 Elsevier Ltd. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Mahajan, S; Slathia, N; Kapoor, KK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 99-93-4. Recently I am researching about ENDOCRINE-DISRUPTING CHEMICALS; HIGH LACCASE ACTIVITY; DEGRADATION; REMOVAL; BIOREMEDIATION; FERREDOXIN; REDUCTION; TOXICITY; EXPOSURE; BACTERIA, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31540067, 21876201]; Basic Research Fund of the Chinese Academy of Agricultural Sciences [1610042017001, 1610042018005, 1610042018006]. Published in MDPI in BASEL ,Authors: Jia, Y; Eltoukhy, A; Wang, JH; Li, XJ; Hlaing, TS; Aung, MM; Nwe, MT; Lamraoui, I; Yan, YC. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30 degrees C and 6.5, respectively. The biodegradation pathway was proposed based on the identification of the metabolites. The addition of cytochrome P450 (CYP) inhibitor 1-aminobenzotriazole significantly decreased the degradation of BPA by Sphingobium sp. YC-JY1. Escherichia coli BL21 (DE3) cells harboring pET28a-bisdAB achieved the ability to degrade BPA. The bisdB gene knockout strain YC-JY1 Delta bisdB was unable to degrade BPA indicating that P450(bisdB) was an essential initiator of BPA metabolism in strain YC-JY1. For BPA polluted soil remediation, strain YC-JY1 considerably stimulated biodegradation of BPA associated with the soil microbial community. These results point out that strain YC-JY1 is a promising microbe for BPA removal and possesses great application potential.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jia, Y; Eltoukhy, A; Wang, JH; Li, XJ; Hlaing, TS; Aung, MM; Nwe, MT; Lamraoui, I; Yan, YC or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines WOS:000576785800009 published article about BIOLOGICAL EVALUATION; TUBULIN INHIBITORS; ANTICANCER AGENTS; COMBRETASTATIN ANALOGS; COLCHICINE SITE; BINDING; DERIVATIVES; PHOSPHATE; DESIGN; CYTOTOXICITY in [Dwivedi, Ashish Ranjan; Kumar, Vijay; Kaur, Harmeet; Kumar, Naveen; Poduri, Ramarao; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda 151001, Punjab, India; [Yadav, Ravi Prakash; Baranwal, Somesh] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Microbiol, Bathinda 151001, Punjab, India; [Kumar, Vinod] Cent Univ Punjab, Lab Organ & Med Chem, Dept Chem, Bathinda 151001, Punjab, India in 2020.0, Cited 47.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 mu M, 4.78 mu M and 4.23 mu M, HK-10 showed IC50 values of 0.81 mu M, 5.89 mu M, 4.96 mu M and HK-13 showed IC50 values 3.24 mu M, 4.93 mu M and 4.73 mu M against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 mu M against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones WOS:000509895700019 published article about ARYLOXIME ETHERS; OXIME ETHERS; PHENYLBORONIC ACIDS; REARRANGEMENT; BENZOFURANS; CYCLIZATION; ARYLATION; DERIVATIVES; COMPLEX in [Reeta; Kaushik, Kumar; Singh, Raj Pal] DRDO, Ctr Fire Explos & Environm Safety, Delhi, India; [Reeta] Univ Delhi, Dept Chem, Delhi, India; [Rangarajan, T. M.; Singh, Rishi Pal] Univ Delhi, Sri Venkateswara Coll, Dept Chem, New Delhi, India; [Singh, Manjula] Univ Delhi, Shivaji Coll, Dept Chem, New Delhi, India in 2020.0, Cited 69.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C-O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand tBuXPhos (L2) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Reeta; Rangarajan, TM; Kaushik, K; Singh, RP; Singh, M; Singh, RP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Atom Transfer Oxidative Radical Cascade of Aryl Alkynoates towards 1,1-Dichalcogenide Olefins WOS:000477143100001 published article about METAL-FREE; STEREOSELECTIVE-SYNTHESIS; ALKENE DERIVATIVES; ACTIVATED ALKYNES; CYCLIZATION; MIGRATION; ACIDS; DIFUNCTIONALIZATION; COUMARINS; BOND in [Sahoo, Harekrishna; Ramakrishna, Isai; Mandal, Anup; Baidya, Mahiuddin] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2019, Cited 70. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

An oxidative trifunctionalization of aryl alkynoates has been devised via the chalcogenide radical triggered intramolecular 1,4-aryl migration/decarboxylation cascade to prepare 1,1-dichalcogenide tetrasubstituted alkenes in high yields (up to 98 %). This operationally simple reaction proceeds under metal-free conditions, can be executed on gram scale, and highlights formal 1,1-difunctionalization of alkynes. Synthetic potential of this protocol was demonstrated through a twofold cascade rearrangement to access highly conjugated tetra-selenylated alkenes along with a cross-dehydrogenative annulation to prepare fluorene derivative.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 MED CHEM RES published article about VIRUS NEURAMINIDASE; HOMO-LUMO in [Cui, Man-Ying; Nie, Jian-Xia; Yan, Zhong-Zhong; Xiao, Meng-Wu; Lin, Ding; Ye, Jiao; Hu, Ai-Xi] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China in 2019.0, Cited 28.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Three series of thiazolylhydrazone derivatives were designed, synthesized, and evaluated for their neuraminidase (NA) inhibitory activity against influenza virus H1N1 in vitro. Compounds 1 and 2 were synthesized via the one-pot reaction and compound 3 was synthesized in two steps. Pharmacological results showed that the majority of the target compounds 1, 2, and 3 exhibited moderate-to-good influenza NA inhibitory activity. The NA inhibitory activity of the most active compound 2g (IC50=7.12g/ml) is better than that of the lead compound A. Molecular docking was performed to study the possible interactions between compound 2g and the active site of NA. On the basis of biological results, a preliminary structure-activity relationship (SAR) was derived and discussed. Moreover, density functional theory (DFT) calculation was also performed to explain why the thiazolylhydrazone skeleton has NA inhibitory activity, especially compound 2g with the most potent inhibitory activity.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Cui, MY; Nie, JX; Yan, ZZ; Xiao, MW; Lin, D; Ye, J; Hu, AX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase published in 2020.0. Product Details of 99-93-4, Reprint Addresses Tan, W (corresponding author), Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China.; Tan, W (corresponding author), Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Bandar Sunway 47500, Selangor Darul, Malaysia.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), has been approved by U.S. Food and Drug Administration to treat Alzheimer’s disease (AD) and Parkinson’s disease (PD) dementia. In the current work, a bambuterol derivative lacking one of the carbamoyloxy groups on the benzene ring (BMC-1) and its analogues were synthesized using 1-(3-hydroxyphenyl) ethan-1-one and 1-(4-hydroxyphenyl) ethan-1-one as starting materials. In-vitro cholinesterase assay established that nine compounds were more potent to inhibit both electric eel AChE and equine serum BChE than rivastigmine under the same experimental conditions. Further study confirmed that among the nine carbamates, BMC-3 (IC50(AChE) = 792 nM, IC50(BChE) = 2.2 nM) and BMC-16 (IC50(AChE) = 266 nM, IC50(BChE) = 10.6 nM) were excellent cholinesterase inhibitors with potential of permeating through the blood-brain barrier. These carbamates could be used as potential dual inhibitors of AChE and BChE and to discover novel drugs for the treatment of AD and PD dementia.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wu, J; Pistolozzi, M; Liu, SY; Tan, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles