Category: 99-93-4

SDS of cas: 99-93-4. In 2019 CHINESE J ORG CHEM published article about CARBONYL-COMPOUNDS; ASSISTED SYNTHESIS; ACID; OXIDATION; DERIVATIVES; OXIMATION; ISOXAZOLE; ALDEHYDES; CHLORIDE; ROUTE in [Liang, Ling; Mou, Jialing; Chen, Yue; Wang, Mengsha; Hong, Zhi] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Peoples R China in 2019, Cited 67. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Oxime compounds were efficiently synthesized with aromatic or aliphatic ketones and hydroxylamine hydrochloride as raw materials in the PEG-400 solution, using cheap and readily available superfine kaolin as catalyst under microwave irradiation condition. The effects of the catalyst, the solvent type, reaction time, reaction temperature on the reaction were investigated. The structures of the products were detected by melting point, nuclear magnetic resonance, infrared spectroscopy and mass spectrometry data. This method has the advantages of short reaction times (5 similar to 15 min), good yields, and simple operation as well as environmental friendliness. In addition, the preliminary experiment shows that superfine kaolin could also catalyze transoximation reaction and preparation of oxime ether compounds under microwave irradiation with the yields of 42%similar to 67% and 59%similar to 72%.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Liang, L; Mou, JL; Chen, Y; Wang, MS; Hong, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections WOS:000457137200158 published article about IN-VITRO; ANTIFUNGAL AGENTS; AMPHOTERICIN-B; SAPROCHAETE; MECHANISMS; PRODUCTS; EFFICACY in [Bonvicini, Francesca; Gentilomi, Giovanna A.] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Massarenti 9, I-40138 Bologna, Italy; [Gentilomi, Giovanna A.] Alma Mater Studiorum Univ Bologna, S Orsola Malpighi Hosp, Unit Microbiol, Via Massarenti 9, I-40138 Bologna, Italy; [Bressan, Francesca; Gobbi, Silvia; Rampa, Angela; Bisi, Alessandra; Belluti, Federica] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Belmeloro 6, I-40126 Bologna, Italy in 2019.0, Cited 30.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The occurrence of invasive fungal infections represents a substantial threat to human health that is particularly serious in immunocompromised patients. The limited number of antifungal agents, devoid of unwanted toxic effects, has resulted in an increased demand for new drugs. Herein, the chalcone framework was functionalized to develop new antifungal agents able to interfere with cell growth and with the infection process. Thus, a small library of chalcone-based analogues was evaluated in vitro against C. albicans ATCC 10231 and a number of compounds strongly inhibited yeast growth at non-cytotoxic concentrations. Among these, 5 and 7 interfered with the expression of two key virulence factors in C. albicans pathogenesis, namely, hyphae and biofilm formation, while 28 emerged as a potent and broad spectrum antifungal agent, enabling the inhibition of the tested Candida spp. and non-Candida species. Indeed, these compounds combine two modes of action by selectively interfering with growth and, as an added value, weakening microbial virulence. Overall, these compounds could be regarded as promising antifungal candidates worthy of deeper investigation. They also provide a chemical platform through which to perform an optimization process, addressed at improving potency and correcting liabilities.

Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bonvicini, F; Gentilomi, GA; Bressan, F; Gobbi, S; Rampa, A; Bisi, A; Belluti, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article ClO2 pre-oxidation changes the yields and formation pathways of chloroform and chloral hydrate from phenolic precursors during chlorination WOS:000452931600025 published article about DISINFECTION BY-PRODUCTS; DISSOLVED ORGANIC-MATTER; AQUATIC HUMIC MATERIAL; DRINKING-WATER; TRIHALOMETHANE FORMATION; AQUEOUS CHLORINATION; MODEL COMPOUNDS; DIOXIDE; OXIDATION; KINETICS in [Gan, Wenhui; Ge, Yuexian; Zhu, Haihui; Huang, Huang; Yang, Xin] Sun Yat Sen Univ, Sch Environm Sci & Engn, Guangdong Prov Key Lab Environm Pollut Control &, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 51.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

Phenolic moieties in natural organic matter (NOM) are important precursors of disinfection by-products (DBPs). In this study, the formation of chloral hydrate from chlorination of seventeen phenolic compounds, including mono-, di- and tri-hydroxybenzenes, were evaluated and the role of chlorine dioxide (ClO2) pre-oxidation on its formation pathways was explored. Chloroform, was also evaluated for comparison. Chlorination of resorcinol exhibited the highest chloral hydrate yield (2.83 +/- 0.13%) followed by chlorination of 2,4,6-trichlorophenol (0.61 +/- 0.03%). The median of chloral hydrate yields from the tested phenolic compounds was 0.22%. ClO2 pre-oxidation reduced the yields of chloroform from phenol derivatives by 37-97%, except 4-methoxyphenol, catechol and 2,3-dihydroxyphenol. On the contrary, ClO2 pre-oxidation of di- and tri-hydroxybenzenes tended to increase chloral hydrate yields in post-chlorination. Mixed results (both increases and decreases) were observed in chloral hydrate formation from chlorination of mono-hydroxybenzenes after ClO2 pre-oxidation. The changes of their formation were dependent on ClO2 pre-oxidation time and dosages. Identification of transformation products suggested that phenolic compounds were mainly converted to unsaturated carbonyl structures by ClO2. Chlorine substituted benzoquinones and cyclopent-4-ene-1,3-diones were important transformation products after a series of ring open, decarboxylation, hydrolysis and chlorine substitution reactions. The changes in the formation yields of chloral hydrate and chloroform were governed by the difference in initial phenolic precursors and the transformation products after ClO2 pre-oxidation. ClO2 pre-oxidation in water treatment can effectively reduce chloroform formation but may have a risk of increasing chloral hydrate formation. (C) 2018 Elsevier Ltd. All rights reserved.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gan, WH; Ge, YX; Zhu, HH; Huang, H; Yang, X or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4′-Hydroxyacetophenone. In 2021.0 J AM CHEM SOC published article about C-H BONDS; CHEMISTRY in [Pinkert, Tobias; Das, Mowpriya; Schrader, Malte L.; Glorius, Frank] Westfalische Wilhelms Univ Munster, Organ Chem Inst, D-48149 Munster, Germany in 2021.0, Cited 90.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Herein, we describe the formation of quaternary carbon centers with excellent diastereoselectivity via a strain-release protocol. An organometallic species is generated by Cp*Rh(III)-catalyzed C-H activation, which is then coupled with strained bicyclobutanes (BCBs) and a prochiral carbon electrophile in a three-component reaction. This work illustrates a rare example of BCBs in transition metal catalysis and demonstrates their broad potential to access novel reaction pathways. The method developed exhibits ample functional group tolerance, and the products can be further transformed into valuable alpha-quaternary beta-lactones. Preliminary mechanistic investigations suggest a twofold C-C bond cleavage sequence involving sigma-bond insertion and an ensuing beta-carbon elimination event.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Pinkert, T; Das, M; Schrader, ML; Glorius, F or concate me.. Name: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2020.0 ORG BIOMOL CHEM published article about FRIEDEL-CRAFTS ALKYLATION; BRONSTED ACID; COUPLING REACTION; HIGHLY EFFICIENT; ALKYNES; ALDEHYDES; ACCESS; FUNCTIONALIZATION; CONDENSATIONS; VINYLINDOLES in [Lee, Si On; Choi, Jeongin; Kook, Seunghoon; Lee, Sarah Yunmi] Yonsei Univ, Dept Chem, Seoul 03722, South Korea in 2020.0, Cited 62.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

We report herein a Lewis acid-catalyzed nucleophilic double-addition of indoles to ketones under mild conditions. This process occurs with various ketones ranging from dialkyl ketones to diaryl ketones, thereby providing access to an array of bis(indolyl)methanes bearing all-carbon quaternary centers, including tetra-aryl carbon centers. The products can be transformed into bis(indole)-fused polycyclics and bis(indolyl)alkenes.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Lee, SO; Choi, J; Kook, S; Lee, SY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2020.0 MED CHEM RES published article about ANTIDEPRESSANT-LIKE ACTIVITY; BEHAVIORAL DESPAIR; MOLECULAR DOCKING; MICE; ANTICONVULSANT; ANTIOXIDANT; INHIBITION; EXTRACTS in [Jin, Qing-Hao] Zhejiang Ocean Univ, Donghai Sci & Technol Coll, Zhoushan 316000, Zhejiang, Peoples R China; [Chen, Hong-Hai; Chen, Wen-Bo] Hailisheng Pharmaceut Co Ltd, Zhoushan 316000, Zhejiang, Peoples R China; [Fu, Zhi-Yang; Guan, Li-Ping] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316022, Zhejiang, Peoples R China; [Jiang, Hai-Ying] Jiaxing Univ, Coll Med, Jiaxing 314001, Zhejiang, Peoples R China in 2020.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a-2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h, 2o, 2t, and 2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds 2h, 2o, 2t, and 2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound 2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds 2a-2u also showed the analgesic and anti-inflammatory effects at 30 mg/kg.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jin, QH; Chen, HH; Chen, WB; Fu, ZY; Guan, LP; Jiang, HY or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 BIOCHEMISTRY-US published article about BINUCLEAR METAL CENTER; SP STRAIN TCM1; FLAME RETARDANTS; ACTIVE-SITE; HYDROLYSIS; ENZYME; TOXICITY; PHOSPHORYL; MECHANISM in [Bigley, Andrew N.; Xiang, Dao Feng; Narindoshvili, Tamari; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA; [Burgert, Charlie W.; Hengge, Alvan C.] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA in 2019.0, Cited 38.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

Organophosphorus flame retardants are stable toxic compounds used in nearly all durable plastic products and are considered major emerging pollutants. The phosphotriesterase from Sphingobium sp. TCM1 (Sb-PTE) is one of the few enzymes known to be able to hydrolyze organophosphorus flame retardants such as triphenyl phosphate and tris(2-chloroethyl) phosphate. The effectiveness of Sb-PTE for the hydrolysis of these organophosphates appears to arise from its ability to hydrolyze unactivated alkyl and phenolic esters from the central phosphorus core. How Sb-PTE is able to catalyze the hydrolysis of the unactivated substituents is not known. To interrogate the catalytic hydrolysis mechanism of Sb-PTE, the pH dependence of the reaction and the effects of changing the solvent viscosity were determined. These experiments were complemented by measurement of the primary and secondary 18-oxygen isotope effects on substrate hydrolysis and a determination of the effects of changing the pK(a) of the leaving group on the magnitude of the rate constants for hydrolysis. Collectively, the results indicated that a single group must be ionized for nucleophilic attack and that a separate general acid is not involved in protonation of the leaving group. The Bronsted analysis and the heavy atom kinetic isotope effects are consistent with an early associative transition state with subsequent proton transfers not being rate limiting. A novel binding mode of the substrate to the binuclear metal center and a catalytic mechanism are proposed to explain the unusual ability of Sb-PTE to hydrolyze unactivated esters from a wide range of organophosphate substrates.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bigley, AN; Xiang, DF; Narindoshvili, T; Burgert, CW; Hengge, AC; Raushel, FM or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2019.0 MOL DIVERS published article about BENZAMIDE; DISCOVERY; ALPHA; ACIDS in [Nian, Si-Yun; Jiang, Zheng-Li] Taizhou Hosp Zhejiang Prov, Dept Clin Pharm, Xi Men St 150, Linhai 317000, Zhejiang, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping; Xiao, Ying] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping] Aurisco Pharmaceut Yangzhou Co Ltd, Yangzhou 225100, Jiangsu, Peoples R China; [Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China in 2019.0, Cited 21.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 +/- 1.1 mu M) showed better activity compared to SIPI-7623 (IC50 = 40.8 +/- 1.7 mu M) and guggulsterone (IC50 = 45.9 +/- 1.1 mu M). Docking of A-11 in FXR’s ligand-binding domain was also studied.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Nian, SY; Wang, GP; Jiang, ZL; Xiao, Y; Huang, MH; Zhou, YH; Tan, XD or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Magnetically recoverable graphene oxide supported Co@Fe3O4/L-dopa for C-C cross-coupling and oxidation reactions in aqueous medium WOS:000466253900004 published article about HIGHLY EFFICIENT; CATALYST; SUZUKI; REDUCTION; NANOPARTICLES; NANOCATALYSTS; HECK; NITROAROMATICS; NANOCOMPOSITE; COMPOSITE in [Sharma, Harsha; Sharma, Shally; Sharma, Chandan; Paul, Satya] Univ Jammu, Dept Chem, Jammu 180006, Jammu & Kashmir, India; [Clark, James H.] Univ York, Dept Chem, Green Chem Ctr Excellence, York YO10 5DD, N Yorkshire, England in 2019, Cited 50. Safety of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We report the synthesis of inexpensive and environmentally benign cobalt(0) nanoparticles on L-3,4-dihydroxyphenylalanine (L-dopa) functionalized and magnetite (Fe3O4) grafted graphene oxide (Co@GO/Fe3O4/L-dopa) which was fully characterized with different techniques such as Scanning Electron Microscopy (SEM), High Resolution Transmission Electron Microscopy (HR-TEM), X-Ray Photoelectron Spectroscopy (XPS), X-ray Powder Diffraction (XRD), Thermogravimetric analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Vibrating Sample Magnetometer (VSM), Carbon Hydrogen Nitrogen (CHN) analysis, Energy Dispersive X-ray (EDX) and Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). Graphene oxide was used as the core material due to its mechanical, electrical and thermal properties. In order to avoid the cumbersome process of separation, magnetite nanoparticles were coated over the graphene oxide. After the successful preparation of graphene oxide based magnetic nanoparticles, L-dopa was grafted over Fe3O4 nanoparticles so as to provide firm anchoring agent for cobalt nanoparticles. Finally, cobalt(0) nanoparticles were immobilized on the developed magnetic support. The catalytic efficiency of the synthesized catalyst was tested for Suzuki cross-coupling and oxidation reactions, usually carried out by precious and expensive second and third row transition metals; products were obtained in good to excellent yields. The synthesized catalyst represents an attractive alternative to conventional catalysts for Suzuki cross-coupling and oxidation reactions, and is recyclable up to five runs.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Sharma, H; Sharma, S; Sharma, C; Paul, S; Clark, JH or concate me.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Detoxification of host plant phenolic aglycones by the spruce budworm WOS:000468030100002 published article about GLUTATHIONE-S-TRANSFERASE; HELICOVERPA-ARMIGERA; MIDGUT; RESISTANCE; ECOLOGY; TANNINS; PH in [Donkor, Dominic; Mirzahosseini, Zahra; Despland, Emma] Concordia Univ, Biol Dept, Montreal, PQ, Canada; [Bede, Jacquie] McGill Univ, Dept Plant Sci, Ste Anne De Bellevue, PQ, Canada; [Bauce, Eric] Univ Laval, Dept Sci Bois & Foret, Ste Foy, PQ, Canada in 2019.0, Cited 40.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

This study examines the post-ingestive fate of two host-plant derived small-molecule phenolics (the acetophenones piceol and pungenol) that have previously been shown to be toxic to the outbreaking forest pest, spruce budworm (Choristoneura fumiferana). We test first whether these compounds are transformed during passage through the midgut, and second whether the budworm upregulates activity of the detoxification enzyme glutathione-s-transferase (GST) in response to feeding on these compounds. Insects were reared on either foliage or artificial diet to the fourth instar, when they were transferred individually to one of two treatment diets, either control or phenolic-laced, for approximately 10 days, after which midguts were dissected out and used for Bradford soluble protein and GST enzyme activity analysis. Frass was collected and subjected to HPLC-DAD-MS. HPLC showed that the acetophenones do not autoxidize under midgut pH conditions, but that glucose- and glutathione-conjugates are present in the frass of insects fed the phenolic-laced diet. GST enzyme activity increases in insects fed the phenolic-laced diet, in both neutral pH and alkaline assays. These data show that the spruce budwom exhibits counter-adaptations to plant phenolics similar to those seen in angiosperm feeders, upregulating an important detoxifying enzyme (GST) and partially conjugating these acetophenones prior to elimination, but that these counter-measures are not totally effective at mitigating toxic effects of the ingested compounds in the context of our artifical-diet based laboratory experiment.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Donkor, D; Mirzahosseini, Z; Bede, J; Bauce, E; Despland, E or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles