Category: 99-93-4

In 2020.0 POLYCYCL AROMAT COMP published article about ASYMMETRIC-SYNTHESIS; EFFICIENT METHOD; IONIC LIQUID; THIAZOLES; ALCOHOLS; KETONES in [Safari, Javad; Shokrani, Zahra] Univ Kashan, Coll Chem & Biochem, Dept Organ Chem, Lab Organ Compound Res, Kashan, IR, Iran; [Zarnegar, Zohre] Univ Payame Noor, Dept Chem, Res Affiliate, Tehran, Iran in 2020.0, Cited 23.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone

In this research, an efficient method for the one-pot synthesis of 2-aminothiazolesviathe reaction of thiourea with methylcarbonyls in the presence of iodine as an oxidant reagent has been developed using asparagine as a green organocatalyst at 80 degrees C in DMSO solvent. Advantages of this efficient method include greener and cleaner conditions, easy isolation of products, higher purity and excellent yield of products, and convenient manipulation.

Name: 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Safari, J; Shokrani, Z; Zarnegar, Z or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. In 2019.0 J MED CHEM published article about POTENTIAL ORAL TREATMENT; PROGRAMMED CELL-DEATH; REACTIVE OXYGEN; NITRIC-OXIDE; ANTILEISHMANIAL ACTIVITY; DRUG-RESISTANCE; OXIDATIVE STRESS; DONOVANI; THERAPY; ACTIVATION in [Upadhyay, Akanksha; Gupta, Sampa; Kushwaha, Pragati; Sashidhara, Koneni V.] CSIR Cent Drug Res Inst, Med & Proc Chem Div, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Chandrakar, Pragya; Parmar, Naveen; Kar, Susanta] CSIR Cent Drug Res Inst, Div Parasitol, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Singh, Sandeep Kumar; Rashid, Mamunur; Wahajuddin, Muhammad] CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Upadhyay, Akanksha; Chandrakar, Pragya; Gupta, Sampa; Parmar, Naveen; Singh, Sandeep Kumar; Rashid, Mamunur; Kushwaha, Pragati; Wahajuddin, Muhammad; Sashidhara, Koneni V.; Kar, Susanta] Acad Sci & Innovat Res AcSIR, Anusandhan Bhawan, New Delhi 110025, India in 2019.0, Cited 69.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. Among all synthesized derivatives, 15b and 15i showed significant antileishmanial efficacy against both extracellular promastigote (IC50 9.54 and 5.42 mu M, respectively) and intracellular amastigote (IC50 9.81 and 3.75 mu M, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host 0774 macrophages, Vero cells). However, compound 15i effectively inhibited the parasite burden in the liver and spleen (>80%) of infected BALB/c mice. Mechanistic studies revealed that 15i triggers oxidative stress which induces bioenergetic collapse and apoptosis of the parasite by decreasing ATP production and mitochondrial membrane potential. Structure activity analyses and pharmacokinetic studies suggest 15i as a promising antileishmanial lead and emphasize the importance of quinoline metronidazole series as a suitable platform for the future development of antileishmanial agents.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Upadhyay, A; Chandrakar, P; Gupta, S; Parmar, N; Singh, SK; Rashid, M; Kushwaha, P; Wahajuddin, M; Sashidhara, KV; Kar, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region WOS:000592529800004 published article about ACID PHENETHYL ESTER; DRUG DISCOVERY; DERIVATIVES; IMIDAZOLE; INDUCERS; ANALOGS in [Floresta, Giuseppe; Fallica, Antonino N.; Romeo, Giuseppe; Sorrenti, Valeria; Salerno, Loredana; Rescifina, Antonio; Pittala, Valeria] Univ Catania, Dept Drug Sci, Vle Doria 6, I-95125 Catania, Italy; [Floresta, Giuseppe] Kings Coll London, Dept Analyt Environm & Forens, Stamford St, London SE1 9NH, England in 2020.0, Cited 54.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The enzymatic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chemical modulators and the greater attentiveness towards HO-1 isoform. In the present paper, we report the rational design and synthesis of HO-2 inhibitors achieved by modulating the volume of known HO-1 inhibitors. The inhibition preference has been moved from HO-1 to HO-2 by merely increasing the volume of the substituent in the western region of the inhibitors. Docking studies demonstrated that new derivatives soak differently in the two binding pockets, probably due to the presence of a Tyr187 residue in HO-2. These findings could be useful for the design of new selective HO-2 compounds.

Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Recently I am researching about COLCHICINE BINDING; TUBULIN INHIBITORS; COMBRETASTATIN; POTENT; SITE; CHALCONOIDS; CANCER, Saw an article supported by the Research Council of Mazandaran University of Medical Sciences, Sari, Iran [2572]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ansari, M; Shokrzadeh, M; Karima, S; Rajaei, S; Hashemi, SM; Mirzaei, H; Fallah, M; Emami, S. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Several flexible and rigid analogs of 4H-1,2,4-triazoles (compounds 8a-g and 9a-g) bearing trimethoxyphenyl pharmacophoric unit, were designed and synthesized as potential anticancer agents. The in vitro cytotoxic assay indicated that both flexible and rigid analogs (8 and 9, respectively) can potentially inhibit the growth of cancerous cells (A549, MCF7, and SKOV3), with IC50 values less than 5.0 mu M. Furthermore, compounds 10a-l as regional isomers of compounds 9 exhibited remarkable cytotoxic activity with IC50 values ranging from 0.30 to 5.0 mu M. The rigid analogs 9a, 10h and 10k were significantly more potent than etoposide against MCF7, SKOV3 and A549 cells, respectively. These compounds showed high selectivity towards cancer cells over normal cells, as they had no significant cytotoxicity against L929 cells. In addition, the representative compounds 9a and 10h could inhibit the tubulin polymerization at micro-molar levels. By determining changes in the colchicine-tubulin fluorescence, it was suggested that compound 10h could bind to the tubulin at the colchicine pocket. The molecular docking study further confirmed the inhibitory activity of promising compounds 9a, 10h and 10k on tubulin polymerization through binding to the colchicine-binding site.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ansari, M; Shokrzadeh, M; Karima, S; Rajaei, S; Hashemi, SM; Mirzaei, H; Fallah, M; Emami, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mitra, B; Pariyar, GC; Ghosh, P in [Mitra, Bijeta; Ghosh, Pranab] Univ North Bengal, Dept Chem, Raja Rammohunpur, W Bengal, India; [Pariyar, Gyan Chandra] Univ North Bengal, Dept Food Technol, Raja Rammohunpur, W Bengal, India published beta-Cyclodextrin: a supramolecular catalyst for metal-free approach towards the synthesis of 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1H)-one in 2021, Cited 95. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

beta-Cyclodextrin, a green and widespread supramolecular catalyst, has been explored as a highly proficient promoter for the metal-free one-pot multi-component synthesis of a vast range of highly functionalized bioactive heterocyclic moiety, 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1H)-one, from easily available precursor aldehydes. The main endeavor of these protocols is to explore this organic supramolecule in one-pot multi-component synthesis. Absence of metal catalyst or toxic acid and harsh reaction conditions, excellent functional group tolerance, inexpensive, greener and environmentally safe protocol are the key advantages of this work.

Welcome to talk about 99-93-4, If you have any questions, you can contact Mitra, B; Pariyar, GC; Ghosh, P or send Email.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 99-93-4. Authors Bakr, EA; Al-Jumaili, MHA in TAYLOR & FRANCIS LTD published article about in [Bakr, Ekhlas Aziz] Minst Educ, Al Anbar, Iraq; [Al-Jumaili, Mohammed Hadi Ali] Al Maarif Univ Coll, Dept Med Lab Tech, Al Anbar 36015, Iraq; [Al-Jumaili, Mohammed Hadi Ali] Dijlah Univ Coll, Med Coll, Baghdad, Iraq in 2020.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

New series of chalcone derivatives were built up from fluorobenzaldehyde and 4-hydroxyacetophenone as a starting material then further reacted with terminal alkylester chains to obtain the target compounds. The effect of the terminal chain on mesogenic and photochemical properties was discussed in detail. These series consist of four compounds that differ by the length of the alkyl chain.The branched-arm and chiral core quantity affected the liquid crystalline properties. The synthesized compounds were investigated for their liquid crystal properties and mesophase characteristics by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). The compounds (5-7) display nematic phase in the heating cycle while there is no liquid crystal behavior of compound (4). Studying the structure-property relationship and the presence of the halogen atom, it was proposed that, the less carbons number in the alkyle chain will increase the phase transition temperature to generate the nematic phase. The molecular structure of the synthesized compounds was confirmed by spectroscopic analysis.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article High dielectric, low curing with high thermally stable renewable eugenol-based polybenzoxazine matrices and nanocomposites WOS:000451334300001 published article about RING-OPENING POLYMERIZATION; BIO-BASED BENZOXAZINES; POLYMERS; MONOMERS; CARDANOL; CURE in [Krishnan, S.; Arumugam, H.; Chavali, M.; Muthukaruppan, A.] Vignans Univ, Ctr Excellence Adv Mat Mfg Proc & Characterizat C, Guntur 522213, India in 2019.0, Cited 36.0. SDS of cas: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

In the present work, a new type of bio-based benzoxazines were prepared by using aniline, N, N-dimethyl amino propyl amine (DMAPA) and caprolactam modified DMAPA with eugenol. The benzoxazines resulted were characterized for their molecular structure by Fourier transform infrared and nuclear magnetic resonance spectroscopy. The polymerization process of benzoxazines and their thermal behavior were studied by differential scanning calorimetry and thermogravimetric analysis, respectively. Moreover, the effect of chemical blending of the synthesized benzoxazines with conventional benzoxazines [bisphenol A benzoxazine (BPAb) and bisphenol F benzoxazine (BPFb)] and bismaleimide was studied to bring down the polymerization temperature by creating supplementary potential sites for polymerization. Furthermore, to reduce the polymerization temperature, the benzoxazines synthesized in the present study were partially incorporated with 10 wt % of catalysts (4-hydroxy phenylmaleimide, 4-amino phenol, and 4-hydroxy acetophenone). The graphene reinforced polybenzoxazine composites were also prepared by incorporating varying weight percentages (1, 3, 5, 7, and 10 wt %) of graphene oxide to obtain hybrid nanocomposites. From the results obtained, it was observed that the polymerization temperature (T-p) was significantly reduced (more than 31 degrees C) in both the cases of blends of conventional BPAb and BPFb. It was also observed that the values of the dielectric constant of graphene reinforced hybrid composites are significantly enhanced. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47050.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Krishnan, S; Arumugam, H; Chavali, M; Muthukaruppan, A or concate me.. SDS of cas: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 CRYST GROWTH DES published article about THEORETICAL DATA-BANK; MOLECULAR-CRYSTALS; ENERGY; REFINEMENT; PREDICTION; PARAMETERS; QUALITY; PACKING; SYSTEM; ATOMS in [Sztylko, Marcin; Malinska, Maura; Hoser, Anna A.] Univ Warsaw, Fac Chem, Biol & Chem Res Ctr, Zwirki I Wigury 101, PL-02089 Warsaw, Poland; [Petricek, Vaclav] Acad Sci Czech Republ, Inst Phys, Na Slovance 2, Prague 18221, Czech Republic; [Gutmann, Matthias J.] Rutherford Appleton Lab, Sci & Tech Facil Council, ISIS Neutrons & Muons Facili, Harwell Sci Campus, Didcot OX11 OQX, Oxon, England in 2019.0, Cited 40.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Name: 4′-Hydroxyacetophenone

Technical progress in crystallographic instruments allows contemporary crystallographers to more routinely conduct excellent quality low-temperature diffraction measurements. As a result, even crystal structures that have been extensively studied at ambient conditions start to reveal their more complex nature. The importance of low-temperature measurements is discussed based on the new, modulated structures found for polymorphs of 4′-hydroxyacetophenone (HAP). Diffraction data for this polymorphic system have been collected in the temperature range from 40 K to 330 K. At 123 K, form II of HAP appears to be a new, commensurately modulated structure with a modulation vector q = [0.4, 0.0, 0.0]. The structure can be solved and refined with 10 molecules in the asymmetric unit. A further decrease of temperature to 40 K resulted in the discovery of a new, incommensurately modulated phase with four independent molecules in the P2(1) monoclinic space group with the modulation vector q = [0.37, 0.17, 0.0]. Consequences of modulation for the relative stability of polymorphs will be discussed.

Name: 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Sztylko, M; Malinska, M; Petricek, V; Gutmann, MJ; Hoser, AA or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V in [Dwivedi, Ashish Ranjan; Kumar, Vijay; Kaur, Harmeet; Kumar, Naveen; Poduri, Ramarao; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda 151001, Punjab, India; [Yadav, Ravi Prakash; Baranwal, Somesh] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Microbiol, Bathinda 151001, Punjab, India; [Kumar, Vinod] Cent Univ Punjab, Lab Organ & Med Chem, Dept Chem, Bathinda 151001, Punjab, India published Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines in 2020.0, Cited 47.0. COA of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 mu M, 4.78 mu M and 4.23 mu M, HK-10 showed IC50 values of 0.81 mu M, 5.89 mu M, 4.96 mu M and HK-13 showed IC50 values 3.24 mu M, 4.93 mu M and 4.73 mu M against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 mu M against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.

COA of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4′-Hydroxyacetophenone. Recently I am researching about MONO-MANNICH-BASES; CARBONIC-ANHYDRASE INHIBITORS; CORRESPONDING AZINE DERIVATIVES; ACETYLCHOLINE ESTERASE; BIOLOGICAL EVALUATION; HUMAN HEPATOMA; CYTOTOXICITY; ANTICANCER; PURIFICATION; BIOACTIVITY, Saw an article supported by the Research Foundation of Ataturk University Erzurum (Turkey)Ataturk University. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Kucukoglu, K; Gul, HI; Taslimi, P; Gulcin, I; Supuran, CT. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and Alzheimer’s disease. Keeping this in mind, N, N’-bis[(1-aryl-3-heteroaryl) propylidene] hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. According to the activity results, the most effective inhibitory compounds were in R-series with the K-i values of 203 +/- 55-473 +/- 67 nM and 200 +/- 34-419 +/- 94 nM on hCA I, and hCA II, respectively. N, N’-Bis[1-(4-fluorophenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N8, in N-series, N, N’-Bis[1-(4-hydroxyphenyl)-3-(piperidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, P4, in P-series, and N, N’-bis[1-(4-chlorophenyl)-3-(pyrrolidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, R5, in R-series were the most powerful compounds against hCA I with the K-i values of 438 +/- 65 nM, 344 +/- 64 nM, and 203 +/- 55 nM, respectively. Similarly, N8, P4, and R5 efficiently inhibited hCA II isoenzyme with the K-i values of 405 +/- 60 nM, 327 +/- 80 nM, and 200 +/- 34 nM, respectively. On the other hand, P-series compounds had notable inhibitory effect against AChE than the reference compound tacrine and the K-i values were between 66 +/- 20 nM and 128 +/- 36 nM. N, N’-Bis[1-(4-fluorophenyl)-3-(piperidine-1-yl) propylidene] hydrazine dihydrochlorides, P7, was the most potent compound on AChE with the K-i value of 66 +/- 20 nM. The other most promising compounds, N, N’-bis[1-(4-hydroxyphenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N4 in N-series and N, N’-bis[1-(4-hydroxyphenyl)-3-(pyrrolidine-1-yl) propylidene] hydrazine dihydrochlorides, R4 in R-series were againts AChE with the K-i values of 119 +/- 20 nM, 88 +/- 14 nM, respectively.

Welcome to talk about 99-93-4, If you have any questions, you can contact Kucukoglu, K; Gul, HI; Taslimi, P; Gulcin, I; Supuran, CT or send Email.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles