indole-building-block | - Page 104 of 1434

Mahajan, Y. R. et al. published their research in Science of Synthesis in 2005 | CAS: 150560-58-0

5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Category: indole-building-block

Introduction [Synthesis of amides] was written by Mahajan, Y. R.;Weinreb, S. M.. And the article was included in Science of Synthesis in 2005.Category: indole-building-block This article mentions the following:

A review which constitutes an overview of a whole volume which covers the synthesis of compounds containing an amide moiety, including peptides and lactams. These compounds were divided into groups depending on the type of amide and nature of the substituents around the amide functionality. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Category: indole-building-block).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dassonville, Alexandra et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2004 | CAS: 6639-06-1

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid

New N-pyridinyl(methyl)indolalkanamides acting as topical inflammation inhibitors was written by Dassonville, Alexandra;Breteche, Anne;Evano, Johan;Duflos, Muriel;le Baut, Guillaume;Grimaud, Nicole;Petit, Jean-Yves. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid This article mentions the following:

Title compounds were prepared as non-acidic NSAIDs. Pharmacomodulation was carried out at N(1) and C(5) of the indole ring and at the level of the propanamide chain. N-(Pyridin-3-ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)indol-3-yl]propanamide represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid).

Chen, Changpeng et al. published their research in Organic Letters in 2017 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 1912-45-4

Iridium-Catalyzed, Weakly Coordination-Assisted Ortho-Alkynylation of (Hetero)aromatic Carboxylic Acids without Cyclization was written by Chen, Changpeng;Liu, Pei;Tang, Jinghua;Deng, Gongda;Zeng, Xiaoming. And the article was included in Organic Letters in 2017.Product Details of 1912-45-4 This article mentions the following:

In the presence of [Cp^*IrCl₂]₂, arylcarboxylic acids and arylacetic acids such as 2-methylbenzoic acid or o-methylphenylacetic acid underwent regioselective directed alkynylation with i-Pr₃SiCCBr mediated by KHCO₃ and air in tert-amyl alc. to yield alkynylbenzoic acids and alkynylphenylacetic acids such as I (X = bond, CH₂) in 32-96% yields. Indolyl- and thienyl carboxylic and acetic acids and benzothiopheneacetic acids also underwent regioselective alkynylation. The reaction mechanism was studied using the alkynylation of potassium 2-methylbenzoate without added KHCO₃, deuterium labeling experiments, and the kinetic isotope effects on alkynylation. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Product Details of 1912-45-4).

Barberis, Claude et al. published their research in Tetrahedron Letters in 2005 | CAS: 167631-84-7

Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: Methyl 5-fluoro-1H-indole-2-carboxylate

Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: synthesis of indoles and pyrrolo[2,3-c]pyridines was written by Barberis, Claude;Gordon, Thomas D.;Thomas, Christine;Zhang, Xiaolei;Cusack, Kevin P.. And the article was included in Tetrahedron Letters in 2005.Name: Methyl 5-fluoro-1H-indole-2-carboxylate This article mentions the following:

Over the past few years, the use of palladium-catalyzed aromatic carbon-nitrogen bond forming reactions by the cross-coupling of aryl halides or triflates and amines has become a useful synthetic tool. Herein, a copper(I) catalyst system that allows efficient synthesis of functionalized indoles and pyrrolo[2,3-c]pyridine derivatives was described. This method takes advantage of amino acid promoted copper coupling of amines with aryl halides, in particular, the use of the CuI/L-proline catalyst system. In the experiment, the researchers used many compounds, for example, Methyl 5-fluoro-1H-indole-2-carboxylate (cas: 167631-84-7Name: Methyl 5-fluoro-1H-indole-2-carboxylate).

Molleti, Nagaraju et al. published their research in Organic & Biomolecular Chemistry in 2016 | CAS: 774-47-0

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Quality Control of 5,6-Difluoroindoline-2,3-dione

Catalyst-free synthesis of α¹-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea was written by Molleti, Nagaraju;Yong Kang, Jun. And the article was included in Organic & Biomolecular Chemistry in 2016.Quality Control of 5,6-Difluoroindoline-2,3-dione This article mentions the following:

A highly efficient phospha-aldol reaction for the synthesis of α¹-oxindole-α-hydroxyphosphonates is developed using N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodol. encompasses a variety of isatin derivatives to provide α¹-oxindole- α-hydroxyphosphonates up to 99% yield. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Quality Control of 5,6-Difluoroindoline-2,3-dione).

Prager, Rolf H. et al. published their research in Journal of Heterocyclic Chemistry in 2000 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 5388-42-1

Carbene and radical pathways in pyrolysis of benzisoxazolones and benzotriazoles was written by Prager, Rolf H.;Baradarani, Mehdi M.;Khalafy, Jabbar. And the article was included in Journal of Heterocyclic Chemistry in 2000.Product Details of 5388-42-1 This article mentions the following:

Conference proceedings containing review material. A comparative study of the flash vacuum pyrolysis of a number of N-alkyl- and N-acylbenzotriazoles and -benzisoxazolones has confirmed that carbene-derived pathways predominate at lower temperatures, and radical pathways at higher temperatures Two new general unimol. thermal reactions are also highlighted. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Product Details of 5388-42-1).

Hay, Duncan A. et al. published their research in Journal of the American Chemical Society in 2014 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Related Products of 4583-55-5

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains was written by Hay, Duncan A.;Fedorov, Oleg;Martin, Sarah;Singleton, Dean C.;Tallant, Cynthia;Wells, Christopher;Picaud, Sarah;Philpott, Martin;Monteiro, Octovia P.;Rogers, Catherine M.;Conway, Stuart J.;Rooney, Timothy P. C.;Tumber, Anthony;Yapp, Clarence;Filippakopoulos, Panagis;Bunnage, Mark E.;Muller, Susanne;Knapp, Stefan;Schofield, Christopher J.;Brennan, Paul E.. And the article was included in Journal of the American Chemical Society in 2014.Related Products of 4583-55-5 This article mentions the following:

Small-mol. inhibitors that target bromodomains outside of the bromodomain and extra-terminal (BET) sub-family are lacking. Here, the authors describe highly potent and selective ligands for the bromodomain module of the human lysine acetyl transferase CBP/p300, developed from a series of 5-isoxazolyl-benzimidazoles. The starting point was a fragment hit, which was optimized into a more potent and selective lead using parallel synthesis employing Suzuki couplings, benzimidazole-forming reactions, and reductive aminations. The selectivity of the lead compound against other bromodomain family members was investigated using a thermal stability assay, which revealed some inhibition of the structurally related BET family members. To address the BET selectivity issue, x-ray crystal structures of the lead compound bound to the CREB binding protein (CBP) and the first bromodomain of BRD4 (BRD4(1)) were used to guide the design of more selective compounds The crystal structures obtained revealed two distinct binding modes. By varying the aryl substitution pattern and developing conformationally constrained analogs, selectivity for CBP over BRD4(1) was increased. The optimized compound is highly potent (K_d = 21 nM) and selective, displaying 40-fold selectivity over BRD4(1). Cellular activity was demonstrated using fluorescence recovery after photo-bleaching (FRAP) and a p53 reporter assay. The optimized compounds are cell-active and have nanomolar affinity for CBP/p300; therefore, they should be useful in studies investigating the biol. roles of CBP and p300 and to validate the CBP and p300 bromodomains as therapeutic targets. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Related Products of 4583-55-5).

Silveira, Claudio C. et al. published their research in Tetrahedron Letters in 2010 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Formula: C14H9NO2S

The use of anhydrous CeCl₃ as a catalyst for the synthesis of 3-sulfenyl indoles was written by Silveira, Claudio C.;Mendes, Samuel R.;Wolf, Lucas;Martins, Guilherme M.. And the article was included in Tetrahedron Letters in 2010.Formula: C14H9NO2S This article mentions the following:

Anhydrous CeCl₃ was successfully used as a catalyst for the synthesis of several 3-sulfenyl indoles in good to excellent yields through the reaction of indoles with N-(alkylthio) and N-(arylthio)phthalimides in DMF. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Formula: C14H9NO2S).

Wu, Yinrong et al. published their research in Organic Letters in 2021 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C10H8ClNO2

Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds was written by Wu, Yinrong;Wen, Kangmei;Chen, Jiewen;Shi, Jie;Yao, Xingang;Tang, Xiaodong. And the article was included in Organic Letters in 2021.Computed Properties of C10H8ClNO2 This article mentions the following:

A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described for the synthesis of ((indolyl)methyl)-oxocycloalkyl-esters, e.g., I. Significantly, methanocycloocta[b]indoles II [R = COOEt, CONHEt, SO₂Ph, etc.; R¹ = H, 4-Cl, 5-Br, etc.] were also obtained by sequential intramol. dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations, and good yields. Moreover, the products exhibited potent antiproliferative activity against the human cancer cell lines by a MTT assay. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Computed Properties of C10H8ClNO2).

Mironov, Yu. V. et al. published their research in Russian Chemical Bulletin in 2010 | CAS: 14204-27-4

A study of the mechanism of the azidophenylselenylation of glycals was written by Mironov, Yu. V.;Grachev, A. A.;Lalov, A. V.;Sherman, A. A.;Egorov, M. P.;Nifantiev, N. E.. And the article was included in Russian Chemical Bulletin in 2010.Computed Properties of C14H9NO2S This article mentions the following:

Chem. and physicochem. studies of homogeneous azidophenylselenylation of glycols with diacetoxyiodobenzene, trimethylsilyl azide, and di-Ph diselenide in dichloromethane revealed that the most probable key reaction step is the formation of phenylselenyl azide, an azide radical donor. A method for azidophenylsulfenylation of glycals, e.g. I, with diacetoxyiodobenzene, di-Ph diselenide, and sodium azide to give the corresponding glycosides, e.g. II, was proposed. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Computed Properties of C14H9NO2S).