indole-building-block | - Page 106 of 1434

Cascioferro, Stella et al. published their research in European Journal of Medicinal Chemistry in 2019 | CAS: 90271-86-6

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C9H5BrN2

2,6-Disubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent Staphylococcal biofilm inhibitors was written by Cascioferro, Stella;Parrino, Barbara;Petri, Giovanna Li;Cusimano, Maria Grazia;Schillaci, Domenico;Di Sarno, Veronica;Musella, Simona;Giovannetti, Elisa;Cirrincione, Girolamo;Diana, Patrizia. And the article was included in European Journal of Medicinal Chemistry in 2019.COA of Formula: C9H5BrN2 This article mentions the following:

A class of 36 new 2-(6-phenylimidazo[2,-1-b][1,3,4]thiadiazol-2-yl)-1H-indoles, compounds I [R = H, Cl, Br; R¹ = H, Me; R² = H, 3-MeO, 4F, etc.] was efficiently synthesized and evaluated for their anti-biofilm properties against the Gram-pos. bacterial reference strains Staphylococcus aureus ATCC 25923, S. aureus ATCC 6538 and Staphylococcus epidermidis ATCC 12228, and the Gram-neg. strains Pseudomonas aeruginosa ATCC 15442 and Escherichia coli ATCC 25922. Many of these new compounds, were able to inhibit biofilm formation of the tested Staphylococcal strains showing BIC₅₀ lower than 10 μg/mL. In particular, compounds I [R = H, R¹ = H, R² = 2,5-diMeO; R = H, R¹ = Me, R² = 3-MeO] showed remarkable anti-biofilm activity against S. aureus ATCC 25923 with BIC₅₀ values of 0.5 and 0.8 μg/mL, resp., whereas compound I [R = Cl, R¹ = H, R² = 2,5-diMeO] was the most potent against S. aureus ATCC 6538, with a BIC₅₀ of 0.3 μg/mL. Remarkably, these compounds showed effects in the early stages of the biofilm formation without affecting the mature biofilm of the same strains and the viability of the planktonic form. Their ability in counteracting a virulence factor (biofilm formation) without interfering with the bacterial growth in the free life form make them novel valuable anti-virulence agents. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6COA of Formula: C9H5BrN2).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hase, Y. et al. published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1980 | CAS: 24407-32-7

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Quality Control of 4,5,6,7-Tetrabromoisoindoline-1,3-dione

The IR and Raman spectra of tetrabromophthalic anhydride, tetrabromophthalimide, N-d-tetrabromophthalimide and potassium tetrabromophthalimide was written by Hase, Y.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1980.Quality Control of 4,5,6,7-Tetrabromoisoindoline-1,3-dione This article mentions the following:

The 180-4000-cm^-1 IR and 40-4000-cm^-1 Raman spectra of polycrystalline tetrabromophthalic anhydride, tetrabromophthalimide and its N-deuterio derivative, and K tetrabromophthalimide were recorded and the observed frequencies assigned on the basis of C_2ν mol. symmetry. A normal coordinate anal. was carried out and the carbonyl stretching vibrations were discussed in relation to the obtained force constants In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7Quality Control of 4,5,6,7-Tetrabromoisoindoline-1,3-dione).

Cocordano, Maurice et al. published their research in Annales de la Faculte des Sciences de Marseille in 1970 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 1912-45-4

Relation between electronic structure and auxin activity of chlorinated β-indolylacetic acids was written by Cocordano, Maurice;D’Amato, Franck;Turcat, Jean J.. And the article was included in Annales de la Faculte des Sciences de Marseille in 1970.Recommanded Product: 1912-45-4 This article mentions the following:

Five chlorinated β-indolylacetic acids (I) were prepared by the cyclization of ClC6H4NHN:CHCH2CH2CO2H in ethanolic H2SO4 followed by saponification The auxinic activity of I derivatives was in the order 6-Cl- > nonchlorinated > 6,7-Cl2 > 7-Cl > 5,7-Cl2. The electronic structure of I was calculated by LCAO method. I forms by, its CO2H group, a conjugated unstable complex with the protein of the cell. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Recommanded Product: 1912-45-4).

Huang, Wen-Jun et al. published their research in Journal of Heterocyclic Chemistry in 2022 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

A facile synthesis of pyrrolo[2,3-j]phenanthridines via the cascade reaction of indoleanilines and aldehydes was written by Huang, Wen-Jun;Chen, Zhi-Peng;Liu, Li-Xia;Zhou, Yong-Gui;Wu, Bo;Jiang, Guo-Fang. And the article was included in Journal of Heterocyclic Chemistry in 2022.Category: indole-building-block This article mentions the following:

A facile method for the synthesis of pyrrolo[2,3-j]phenanthridines from indoleanilines and aldehydes in the presence of Broensted acid catalyst and benzoquinone oxidant were established. This approach featured excellent yields, high efficiency and a wide range of substrate scope. Mechanism studies exhibited that this reaction was a cascade process including acid-catalyzed condensation of indoleanilines with aldehydes, cyclization and oxidative aromatization. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Category: indole-building-block).

Tang, Feiying et al. published their research in Industrial & Engineering Chemistry Research in 2019 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 4769-96-4

Creating Coordination Mismatch in MOFs: Tuning from Pore Structure of the Derived Supported Catalysts to Their Catalytic Performance was written by Tang, Feiying;Wang, Liqiang;Zhang, Guangji;Zhang, Min;Liu, You-Nian. And the article was included in Industrial & Engineering Chemistry Research in 2019.Product Details of 4769-96-4 This article mentions the following:

A Ni-substituted ZIF-67 was used as a precursor to prepare hollow-porous-carbon (HPC)-supported catalysts. It was found that Ni²⁺ can partially substitute Co²⁺ to create “defected structure” within ZIF-67, and the secondary pore structure of the derived HPC can be facilely tuned by adjusting the ratio of Ni²⁺ to Co²⁺. Catalyst HPC-Ni-ZIF-1 with hierarchical secondary pore and the largest pore volume exhibits an excellent catalytic performance for the hydrogenation of nitro compounds to corresponding amino compounds In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Product Details of 4769-96-4).

Foa, M. et al. published their research in Journal of Organometallic Chemistry in 1985 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 2-Phenylisoindolin-1-one

Cobalt-catalyzed carbonylation of aryl halides was written by Foa, M.;Francalanci, F.;Bencini, E.;Gardano, A.. And the article was included in Journal of Organometallic Chemistry in 1985.Quality Control of 2-Phenylisoindolin-1-one This article mentions the following:

Carbonylation of aromatic and heteroaromatic halides with a catalytic system of alkylcobalt carbonyl complexes, either preformed or made in situ, and bases such as alkoxides, NaOH, and K₂CO₃ in aliphatic alcs produced aromatic esters, acids, lactones, and lactams in high yield and under mild conditions. New anionic cobalt complexes were formed which were characterized by high reactivity toward aromatic halides. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Quality Control of 2-Phenylisoindolin-1-one).

Oseka, Maksim et al. published their research in Organic Letters in 2016 | CAS: 112656-95-8

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Synthetic Route of C8H4N2O4

Asymmetric Organocatalytic Wittig [2,3]-Rearrangement of Oxindoles was written by Oseka, Maksim;Kimm, Mariliis;Kaabel, Sandra;Jarving, Ivar;Rissanen, Kari;Kanger, Tonis. And the article was included in Organic Letters in 2016.Synthetic Route of C8H4N2O4 This article mentions the following:

A highly enantioselective organocatalytic [2,3]-rearrangement of oxindole derivatives is presented. The reaction was catalyzed by squaramide, and this provides access to 3-hydroxy 3-substituted oxindoles I and II (Ar = Ph, 4-ClC₆H₄, 3-ClC₆H₄, 2-ClC₆H₄, 4-MeOC₆H₄, 4-NO₂C₆H₄, 2-thienyl, 2-naphthyl, etc.; R¹ = H, 5-F, 7-F, 5-MeO, 5-Br, 7-NO₂, etc.; R² = H, Bn, Me, i-Pr, 4-MeC₆H₄CH₂) in high enantiomeric purities. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Synthetic Route of C8H4N2O4).

Coyle, Robert et al. published their research in Journal of Organic Chemistry in 2014 | CAS: 6639-06-1

3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

Tandem Reactions via Barton Esters with Intermolecular Addition and Vinyl Radical Substitution onto Indole was written by Coyle, Robert;McArdle, Patrick;Aldabbagh, Fawaz. And the article was included in Journal of Organic Chemistry in 2014.Category: indole-building-block This article mentions the following:

A one-pot initiator-free Barton ester decomposition with tandem radical addition onto alkyl propiolates or phenylacetylene with aromatic substitution of the resultant vinyl radical allows convenient access to new 9-substituted 6,7-dihydropyrido[1,2-a]indoles, e.g., I (X = Me, CHO, CN; R = Me, Et, t-Bu). Pr radical cyclizations compete when forming the expanded 7,8-dihydro-6H-azepino[1,2-a]indole system. 2-Thiopyridinyl S-radical is incorporated into aromatic adducts when using unsubstituted indole-1-alkanoic acid precursors. X-ray crystallog. on substitution products allows selectivity of the radical addition onto less reactive internal alkynes to be determined In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Category: indole-building-block).

Ma, Dengke et al. published their research in Angewandte Chemie, International Edition in 2019 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C10H10BrN

Organocatalytic Enantioselective Functionalization of Unactivated Indole C(sp³)-H Bonds was written by Ma, Dengke;Zhang, Zhihan;Chen, Min;Lin, Zhenyang;Sun, Jianwei. And the article was included in Angewandte Chemie, International Edition in 2019.Computed Properties of C10H10BrN This article mentions the following:

Described here is a direct catalytic asym. functionalization of unactivated alkyl indoles using organocatalysis. In the presence of an effective chiral urea catalyst and a phosphoric acid additive, the intermol. C-C bond formation between alkyl indoles and trifluoropyruvates proceeded with high efficiency and enantiocontrol. Unlike previous asym. C(sp³-H) functionalizations of α-azaarenes, this process does not require the use of either a strong base or an electron-deficient substrate. The excellent enantiocontrol is particularly noteworthy in view of the severe background reaction as well as the complete inability of other types of catalysts evaluated. Control experiments, kinetic studies, and DFT calculations provided important insights into the mechanism. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Computed Properties of C10H10BrN).

Porter, William L. et al. published their research in Phytochemistry (Elsevier) in 1965 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1912-45-4

Molecular requirements for auxin activity. I. Halogenated indoles and indoleacetic acid was written by Porter, William L.;Thimann, Kenneth V.. And the article was included in Phytochemistry (Elsevier) in 1965.Related Products of 1912-45-4 This article mentions the following:

2-Chloroindoleacetic acid had 350% of the activity of indoleacetic acid (IAA) in the pea curvature test; the 2-bromo analog had 160% activity and the corresponding Me and Et esters were even more active. In a series of these and other IAA derivatives, the log of the growth activity is a linear function of the NH stretching frequency in the ir spectra and of the Hammett sigma value for the substituent. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Related Products of 1912-45-4).