indole-building-block | - Page 111 of 1434

Nirwan, Narendra et al. published their research in Indian Journal of Heterocyclic Chemistry in 2018 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C9H6ClNO

An efficient green synthesis of substituted indolylimidazole derivatives by employing reusable catalyst under microwave irradiation was written by Nirwan, Narendra;Pareek, Chandresh;Swami, V. K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2018.COA of Formula: C9H6ClNO This article mentions the following:

A simple highly versatile, green, and efficient one-pot synthesis of highly substituted indolylimidazole derivative I [R = H, Br, Cl, I; Ar = H, C₆H₅, 4-H₃CC₆H₄, 4-H₃COC₆H₄, 4-H₃CH₂COC₆H₄] is achieved by multicomponent condensation of benzil, indole-3-carbaldehydes II, ammonium acetate, and aromatic amines under microwave irradiation using Amberlyst A-15 as a reusable catalyst. This process has features of eco-friendly, very shorter reaction time, cost effectiveness and reusability of catalyst, easy workup, and purification of product with excellent yields. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0COA of Formula: C9H6ClNO).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Li Ming et al. published their research in Chirality in 2018 | CAS: 774-47-0

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Formula: C8H3F2NO2

Urea derivative catalyzed enantioselective aldol reaction of isatins with ketones was written by Wang, Li Ming;Zhao, Mei Jun;Chen, Zhe;Mu, Hong Wen;Jin, Ying. And the article was included in Chirality in 2018.Formula: C8H3F2NO2 This article mentions the following:

An efficient method was developed for the synthesis of 3-alkyl-3-hydroxyindolin-2-ones I (R¹ = H, 5-Me, 7-F, etc.; R² = Me, Ph, 4-ClC₆H₄) via chiral urea-catalyzed asym. aldol reaction of isatins with ketones R²C(O)Me. The resulting products I were obtained in good yields (70%-94%) with high enantioselectivities (up to 87% ee). In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Formula: C8H3F2NO2).

Sharma, Saurabh et al. published their research in New Journal of Chemistry in 2019 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 4769-96-4

Hydrogenation of nitroarenes to anilines in a flow reactor using polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS) was written by Sharma, Saurabh;Yamini;Das, Pralay. And the article was included in New Journal of Chemistry in 2019.Recommanded Product: 4769-96-4 This article mentions the following:

The present methodol. described the chemo-selective hydrogenation of various nitroarenes in a flow reactor under polystyrene supported rhodium in a catalyst-cartridge (Cart-Rh@PS) as a heterogeneous nano-catalyst. The polystyrene supported Rh (Rh@PS) nanoparticles (NPs) were prepared by following our earlier reported protocol and packed inside the catalyst-cartridge (Cat-Cart) to obtain Cart-Rh@PS, which is compatible with ThalesNano’s H-Cube Pro flow system. The advantages of the prepacked catalyst Cart-Rh@PS are as follows: no need for catalyst activation up to 12 runs, negligible metal leaching detected by ICP-AES anal. and significantly less back pressure generated under the flow conditions. The same catalyst, Cart-Rh@PS, was also effective up to a 1 g scale for the reduction of nitroarenes and reusable for successive runs. The hydrogenation in the flow reactor is a greener approach for the reduction of nitroarenes to their corresponding anilines in high yields. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Recommanded Product: 4769-96-4).

Kamila, Sukanta et al. published their research in Open Organic Chemistry Journal in 2011 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 5-Chloroindole-3-carboxaldehyde

Synthesis of novel pyridobenzimidazoles bonded to indole or benzo[b]thiophene structures was written by Kamila, Sukanta;Ankati, Haribabu;Mendoza, Kimberly;Biehl, Edward R.. And the article was included in Open Organic Chemistry Journal in 2011.Recommanded Product: 5-Chloroindole-3-carboxaldehyde This article mentions the following:

Pyridobenzimidazoles I (R¹ = R² = R³ = H, X = NH, Y = CH; R¹ = MeO, R² = R³ = H, X = NH, Y = N; R¹ = R, R² = R³ = H, X = S, Y = CH; etc.) were synthesized in very good to excellent yields (81-96 %) by the condensation of substituted N-phenyl-o-phenylenediamines with indole/benzo[b]thiophene-3-aldehydes 5a-t in methoxyethanol under reflux conditions. The diamines were prepared by first treating 2-chloro-3-nitropyridine with suitably substituted anilines, then reducing the resulting 3-nitro-N-phenylpyridin-2-amines with tin(II)chloride using microwave heating in each case. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Recommanded Product: 5-Chloroindole-3-carboxaldehyde).

Mussari, Christopher P. et al. published their research in ACS Medicinal Chemistry Letters in 2020 | CAS: 90271-86-6

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Formula: C9H5BrN2

Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9) was written by Mussari, Christopher P.;Dodd, Dharmpal S.;Sreekantha, Ratna Kumar;Pasunoori, Laxman;Wan, Honghe;Posy, Shana L.;Critton, David;Ruepp, Stefan;Subramanian, Murali;Watson, Andrew;Davies, Paul;Schieven, Gary L.;Salter-Cid, Luisa M.;Srivastava, Ratika;Tagore, Debarati Mazumder;Dudhgaonkar, Shailesh;Poss, Michael A.;Carter, Percy H.;Dyckman, Alaric J.. And the article was included in ACS Medicinal Chemistry Letters in 2020.Formula: C9H5BrN2 This article mentions the following:

The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate immune system, responsible for the early detection of foreign or endogenous threat signals. In the context of autoimmunity, the unintended recognition of self-motifs as foreign promotes initiation or propagation of disease. Overactivation of TLR7 and TLR9 have been implicated as factors contributing to autoimmune disorders such as psoriasis, arthritis, and lupus. In our search for small mol. antagonists of TLR7/9, 7f(I) was identified as possessing excellent on-target potency for human TLR7/9 as well as for TLR8, with selectivity against other representative TLR family members. Good pharmacokinetic properties and a relatively balanced potency against TLR7 and TLR9 in mouse systems (systems which lack functional TLR8) made this an excellent in vivo tool compound, and efficacy from oral dosing in preclin. models of autoimmune disease was demonstrated. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6Formula: C9H5BrN2).

Gao, Shang et al. published their research in Organic & Biomolecular Chemistry in 2016 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 4583-55-5

Pd(II)-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center was written by Gao, Shang;Yang, Chi;Huang, Yue;Zhao, Lei;Wu, Xiaoming;Yao, Hequan;Lin, Aijun. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 4583-55-5 This article mentions the following:

A Pd(II)-catalyzed intramol. oxidative Heck dearomative reaction for the construction of thiazole-fused pyrrolidinones with a C2-azaquarternary center and C3-exo-double bond has been achieved for the first time. The reaction exhibited good functional group tolerance and gram-scale capacity. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Product Details of 4583-55-5).

Zhang, Huiming et al. published their research in Youji Huaxue in 2014 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Product Details of 4769-96-4

Synthesis of 3-indolyl-substituted benzoboroxole via Friedel-Crafts reaction in water was written by Zhang, Huiming;Shen, Shaochun;Yang, Xiaodi;Sun, Xingwen. And the article was included in Youji Huaxue in 2014.Product Details of 4769-96-4 This article mentions the following:

A highly efficient and catalyst free approach for the synthesis of 3-indolyl-substituted benzoboroxole via Friedel-Crafts reaction in water was developed successfully using readily accessible 2-formylbenzeneboronic acid and indole as the starting material and water as solvent at room temperature An array of desired 3-indolyl-substituted benzoboroxoles was synthesized in moderate to near quant. yield. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Product Details of 4769-96-4).

Rani, B. Shoba et al. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2016 | CAS: 112656-95-8

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 112656-95-8

Cytotoxic, antioxidant and anti-inflammatory activity of N-(6-benzoyl-1H-benzo [d]imidazol-2-yl)-2-(2-oxosubtituted indolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Harikiran, L.;Sammaiah, G.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2016.HPLC of Formula: 112656-95-8 This article mentions the following:

In the present study novel series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxosubstitutedindolin-3-ylidene) hydrazine carboxamides (III a-m) have been synthesized in good yields and characterized by IR, NMR and mass spectral analyses. The compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon ) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay, antioxidant activity by standard DPPH assay method and also were screened for in vitro anti-inflammatory activity by TMPD assay method. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8HPLC of Formula: 112656-95-8).

Liddle, John et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2021 | CAS: 90322-37-5

2-Oxoindoline-4-carboxylic acid (cas: 90322-37-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Synthetic Route of C9H7NO3

The development of highly potent and selective small molecule correctors of Z α₁-antitrypsin misfolding was written by Liddle, John;Pearce, Andrew C.;Arico-Muendel, Christopher;Belyanskaya, Svetlana;Brewster, Andrew;Brown, Murray;Chung, Chun-wa;Denis, Alexis;Dodic, Nerina;Dossang, Anthony;Eddershaw, Peter;Klimaszewska, Diana;Haq, Imran;Holmes, Duncan S.;Jagger, Alistair;Jakhria, Toral;Jigorel, Emilie;Lind, Ken;Messer, Jeff;Neu, Margaret;Olszewski, Allison;Ronzoni, Riccardo;Rowedder, James;Rudiger, Martin;Skinner, Steve;Smith, Kathrine J.;Trottet, Lionel;Uings, Iain;Zhu, Zhengrong;Irving, James A.;Lomas, David A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2021.Synthetic Route of C9H7NO3 This article mentions the following:

α1-Antitrypsin deficiency is characterized by the misfolding and intracellular polymerization of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small mols. that bind and stabilize Z α₁-antitrypsin were identified via a DNA-encoded library screen. A subsequent structure-based optimization led to a series of highly potent, selective and cellular active α1-antitrypsin correctors, e.g., I. In the experiment, the researchers used many compounds, for example, 2-Oxoindoline-4-carboxylic acid (cas: 90322-37-5Synthetic Route of C9H7NO3).

Zhao, Fei et al. published their research in Bioorganic & Medicinal Chemistry in 2016 | CAS: 754214-56-7

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Related Products of 754214-56-7

Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase was written by Zhao, Fei;Zhang, Jing;Zhang, Leduo;Hao, Yu;Shi, Chen;Xia, Guangxin;Yu, Jianxin;Liu, Yanjun. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Related Products of 754214-56-7 This article mentions the following:

Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance. In this study, a series of imidazo[4,5-b]pyrazine derivatives was designed and synthesized, and their inhibitory activities were evaluated in vitro. Structure-activity relationship (SAR) was investigated systematically and docking anal. was performed to elucidate the binding mode, leading to the identification of the most promising compound 1D-2 (I) which exhibited significant inhibitory effect on both enzymic (IC₅₀ = 1.45 nM) and cellular (IC₅₀ = 24.7 nM in H1993 cell line) assays, as well as exquisite selectivity and satisfactory metabolic stability in human and rat liver microsomes. In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7Related Products of 754214-56-7).