indole-building-block | - Page 234 of 1434

Buckman, Brad Owen et al. published their patent in 2014 |CAS: 152213-63-3

The Article related to heteroaryl carbamate preparation lysophosphatidic acid receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of Methyl 2-(6-bromo-1H-indol-3-yl)acetate

On July 24, 2014, Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; Yuan, Shendong published a patent.Reference of Methyl 2-(6-bromo-1H-indol-3-yl)acetate The title of the patent was N-Heteroaryl carbamates as lysophosphatidic acid receptor antagonists and their preparation. And the patent contained the following:

Compounds of formula I, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided. Compounds of formula I wherein one of and B is acetylene and the other is (un)substituted 6- to 11-membered aryl, (un)substituted 5- to 11- membered heteroaryl, (un)substituted 4- to 11-membered heterocyclyl and (un)substituted 4- to 11-membered carbocyclyl; G is (un)substituted 6- to 11-membered aryl, (un)substituted 5- to 11- membered heteroaryl, (un)substituted 5- to 11-membered heterocyclyl and (un)substituted 5- to 11-membered carbocyclyl; D is OH, CO2H and derivatives, CONH2 and derivatives, azolyl, etc.; E is (un)substituted 6- to 10-membered arylene, (un)substituted 3- to 11-membered carbocyclyl, (un)substituted 3- to 11-membered heterocyclyl and (un)substituted 5- to 10-membered heteroarylene; J is (CR4R5)0-3; K is (CR2’R3′)n; M is (CR2R3)m; n and m are independently 0 – 3, provided that the sum of m + n is equal or greater than 1; L1 and L2 are independently a bond, CH2, CC, etc.; L3 is azolyl, thienyl, aminosulfonyl, etc.; L5 is single bond, CH=CH, CC, etc.; dashed bonds are single and double bonds; each Y is independently absent CR9, C(R9)2, N and NH, provided that only one of Y can be absent; R2, R2′, R3 and R3′ are independently H, halo, alkyl, haloalkyl, etc.; R4, R5 and R9 are independently H and (un)substituted alkyl; R4R5 or two adjacent R9 can be taken together to form (un)substituted cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their LPA antagonistic activity. From the assay, it was determined that compound II exhibited EC50 value in the range of greater than or equal to 50 nM and less than or equal to 500 nM. The experimental process involved the reaction of Methyl 2-(6-bromo-1H-indol-3-yl)acetate(cas: 152213-63-3).Reference of Methyl 2-(6-bromo-1H-indol-3-yl)acetate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhong, Wenhe et al. published their patent in 2016 |CAS: 52537-00-5

The Article related to indoline preparation hydroxytryptamine gastrointestinal antiobesity cns, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 6-Chloro-2,3-dihydro-1H-indole

On March 2, 2016, Zhong, Wenhe; Jin, Chuanfei; Zhang, Yingjun; Zhang, Ji published a patent.Reference of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of indoline derivatives for treating or preventing diseases related with 5-HT6 receptor. And the patent contained the following:

The invention relates to indoline derivatives (e.g., I), their stereoisomers, tautomers, nitrogen oxides, solvates, metabolites and pharmaceutically acceptable salts, and prodrugs thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use for treating or preventing diseases related with 5-HT6 receptor. For instance, the invention compound I was prepared and gave a 5-HT6 Ki value of 57 nM. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Reference of 6-Chloro-2,3-dihydro-1H-indole

Cheng, Clifford et al. published their patent in 2012 |CAS: 52537-00-5

The Article related to heterocyclic inhibitor fatty acid binding protein preparation therapy, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 52537-00-5

On May 17, 2012, Cheng, Clifford; Shipps, Gerald W., Jr.; Huang, Xiaohua; Huang, Ying; Shao, Ning; Rao, Ashwin; Palani, Anandan; Orth, Peter; Voigt, Johannes H.; Herr, Robert J.; Rossiter, Lana Michele; Zeng, Qi; Sun, Xianfeng published a patent.Application of 52537-00-5 The title of the patent was Preparation of heterocyclic inhibitors of fatty acid binding protein for use in therapy. And the patent contained the following:

The present invention relates to novel heterocyclic compounds of general formula I (wherein each of X, Y, and Z is C or N; R1 is H, halo, CN, etc.; R2 is OH, halo, C1-6alkyl, etc.; one of R3 and R4 is H or C1-6alkyl, and the other is, e.g., heteroaryl(Ra)3; Ra is H, halo, OH, etc.; or R3 and R4 together are part of a 4-7-membered ring) as Fatty Acid Binding Protein (“”FABP””) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity, or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. Synthetic procedures for preparing I are exemplified. Example compound II, prepared from 6,7-difluoro-3-hydroxyquinoxaline-2-carboxylic acid and racemic-2-(3-chlorobenzyl)pyrrolidine, had a TdF Kd value of 0.08 μM in an assay to demonstrate FABP inhibitory activity. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Application of 52537-00-5

Huang, Qi et al. published their research in Organic Letters in 2018 |CAS: 65417-22-3

The Article related to heteroarene radical alkylation, alkylated heteroarene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Related Products of 65417-22-3

On March 2, 2018, Huang, Qi; Zard, Samir Z. published an article.Related Products of 65417-22-3 The title of the article was Inexpensive Radical Methylation and Related Alkylations of Heteroarenes. And the article contained the following:

A simple method for the introduction of a Me and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-Me pyrrolidone in a microwave oven. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Related Products of 65417-22-3

Jainta, Manuel et al. published their research in European Journal of Organic Chemistry in 2008 |CAS: 79815-20-6

The Article related to diketopiperazine derivative preparation, amino acid cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of H-Idc-OH

On November 30, 2008, Jainta, Manuel; Nieger, Martin; Brase, Stefan published an article.Application In Synthesis of H-Idc-OH The title of the article was Microwave-assisted stereoselective one-pot synthesis of symmetrical and unsymmetrical 2,5-diketopiperazines from unprotected amino acids. And the article contained the following:

The facile condensation of unprotected amino acids by phosphite-promoted one-step coupling reaction is a highly efficient synthesis to generate stereoselective and optically pure sym. and unsym. functionalized diketopiperazines. The use of microwaves enhanced by small amounts of ionic liquid is accompanied by significant improvement in reaction times and yields. Simple filtration through a pad of silica provides the pure compounds in very good to excellent yields. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

Woolford, Alison Jo-Anne et al. published their patent in 2012 |CAS: 52537-00-5

The Article related to bicyclic heterocycle preparation anticancer agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 52537-00-5

On October 26, 2012, Woolford, Alison Jo-Anne; Howard, Steven; Buck, Ildiko Maria; Chessari, Gianni; Johnson, Christopher Norbert; Tamanini, Emiliano; Day, James Edward Harvey; Chiarparin, Elisabetta; Heightman, Thomas Daniel; Frederickson, Martyn; Griffiths-Jones, Charlotte Mary published a patent.Electric Literature of 52537-00-5 The title of the patent was Preparation of bicyclic heterocycles as anticancer agents. And the patent contained the following:

The invention relates to bicyclic heterocycles of formula I and tautomeric and stereochem. isomeric forms, N-oxides, pharmaceutically acceptable salts and the solvates thereof as anticancer agents; their preparation and use in the treatment of cancer. Compounds of formula I wherein ring E is a 6-membered aromatic carbocyclyl and heterocyclyl; G and J are independently C and N; Q is CR and N; R1 is (un)substituted C1-4 alkyl, C2-4 alkenyl and C3-8 cycloalkyl; R2 and R4 are independently (un)substituted H, C1-6 alkyl, C2-6 alkenyl, etc.; R2 and R4 together with the carbon attached form 3- to 10-membered saturated carbocyclyl and heterocyclyl; R3 and R10 are independently (un)substituted H, C1-6 alkyl, C2-6 alkenyl, etc.; R2 and R4 together with the carbon attached form 3- to 10-membered saturated carbocyclyl and heterocyclyl; R is (un)substituted C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, etc.; and tautomeric and stereochem. isomeric forms, N-oxides, pharmaceutically acceptable salts and the solvates thereof, are claimed. Example compound II was prepared by BOC-deprotection of (R)-2-methyl-4-[2-6-methylsulfamoyl-2,3-dihydroindol-1-yl)-2-oxo-ethyl]piperazine-1-carboxylic acid tert-Bu ester. All the invention compounds were evaluated for their antiproliferative activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5

Das, Krishna Kanta et al. published their research in RSC Advances in 2022 |CAS: 79815-20-6

The Article related to aryl indazole alkenyl preparation diastereoselective regioselective, alkyne aryl indazole alkenylation manganese catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Synthetic Route of 79815-20-6

Das, Krishna Kanta; Ghosh, Asim Kumar; Hajra, Alakananda published an article in 2022, the title of the article was Late-stage ortho-C-H alkenylation of 2-arylindazoles in aqueous medium by Manganese(I)-catalysis.Synthetic Route of 79815-20-6 And the article contains the following content:

Earth-abundant and water-tolerant manganese(I) catalyzed alkenylation of 2-arylindazoles I (R = H, F, Cl; R1 = H, 4-Me, 3-Cl, etc.) with alkyl and aryl alkynes R2CCR3 (R2 = H, Ph, Me; R3 = hexyl, Ph, thiophen-3-yl, etc.) through C-H bond activation is described with a unique level of E-selectivity. The reaction proceeds through the control of C3 nucleophilicity of 2-aryl indazoles. This method is applied to the late-stage functionalization of complex mols. including ethinylestradiol, norethisterone, and N-protected amino acid derivatives, e.g., prop-2-yn-1-yl (tert-butoxycarbonyl)-L-phenylalaninate. The kinetic isotope studies suggest that the C-H bond activation step may not be the rate-determining step. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

Shang, Hai et al. published their research in RSC Advances in 2016 |CAS: 883526-76-9

The Article related to indolyl sulfonyltriazole preparation rhodium catalyst intramol cyclization, tetrahydro carboline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 883526-76-9

Shang, Hai; Tian, Yu; Luo, Jun; Li, Lingyu; Tang, Yefeng; Zou, Zhongmei published an article in 2016, the title of the article was Rhodium(II)-catalyzed intramolecular annulation of 1-sulfonyl-1,2,3-triazoles with indoles: facile synthesis of functionalized tetrahydro-β-carbolines.Electric Literature of 883526-76-9 And the article contains the following content:

A novel rhodium(II)-catalyzed intramol. annulation of 1-sulfonyl-1,2,3-triazoles with indoles was developed, which enabled the facile synthesis of various 4-functionalized tetrahydro-β-carbolines as well as relevant scaffolds from readily available starting materials. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Electric Literature of 883526-76-9

Yang, Wu-Lin et al. published their research in ACS Catalysis in 2016 |CAS: 883526-76-9

The Article related to carboline tetrahydro preparation, copper catalyst asym cycloaddition azomethine ylide indolylnitroethylene, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 883526-76-9

On September 2, 2016, Yang, Wu-Lin; Li, Chun-Yan; Qin, Wen-Jing; Tang, Fei-Fei; Yu, Xingxin; Deng, Wei-Ping published an article.HPLC of Formula: 883526-76-9 The title of the article was Cu(I)-Catalyzed Chemoselective and Stereoselective [3 + 3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines. And the article contained the following:

A Cu(I)-catalyzed asym. [3+3] cycloaddition of azomethine ylides with 2-indolylnitroethylenes is described. Challenges confronted in this reaction include chemoselectivity between [3+2] cycloaddition and [3+3] cycloaddition, reactivity and stereoselectivity of intramol. Friedel-Crafts reaction, and enantioselective control for constructing tetrahydro-γ-carbolines bearing multiple stereocenters. In the presence of copper(I)/Ph-Phosferrox complex, an array of chiral tetrahydro-γ-carboline compounds was generally obtained in moderate to high yields (up to 92%) with moderate to high chemoselectivities (up to 94:6 cr) and a high level of stereoselectivity (up to >98:2 dr, >99% ee in most cases). The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9

Zhang, Kaifan et al. published their research in Organic Letters in 2017 |CAS: 883526-76-9

The Article related to tetrahydrocarbolinone preparation cycloaddition alkenylindole in situ formed azaoxyallyl cation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 883526-76-9

On May 19, 2017, Zhang, Kaifan; Xu, Xiaoying; Zheng, Jiuan; Yao, Hequan; Huang, Yue; Lin, Aijun published an article.HPLC of Formula: 883526-76-9 The title of the article was [3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones. And the article contained the following:

A novel [3 + 3] cycloaddition between in situ formed azaoxyallyl cations and 2-alkenylindoles has been developed. This concise method allows the efficient construction of a series of tetrahydro-β-carbolinones in good yields under mild conditions. Gram-scale experiments and further derivatization of tetrahydro-β-carbolinones highlighted the potential utility of our method. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9