indole-building-block | - Page 298 of 1434

Xu, Hui’s team published research in Bioorganic & Medicinal Chemistry Letters in 2010-12-15 | 4771-48-6

Bioorganic & Medicinal Chemistry Letters published new progress about Fungicides. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Safety of 4-Methyl-1H-indole-3-carbaldehyde.

Xu, Hui; Wang, Yang-Yang published the artcile< Antifungal agents. Part 5: Synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles>, Safety of 4-Methyl-1H-indole-3-carbaldehyde, the main research area is arylsulfonylacylindole aminoguanidine preparation antifungal structure activity relationship.

In order to discover more promising antifungal agents, a series of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles were prepared and evaluated in vitro for their antifungal activities against seven phytopathogenic fungi. Some of the compounds exhibited more potent antifungal activities than or comparable to hymexazol, a com. available agricultural fungicide at the concentration of 100 μg/mL. Preliminary structure-activity relationships of antifungal activities were investigated.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Luise, Nicola’s team published research in European Journal of Organic Chemistry in 2019 | 93247-78-0

European Journal of Organic Chemistry published new progress about Bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 93247-78-0 belongs to class indole-building-block, and the molecular formula is C10H9NO2, Electric Literature of 93247-78-0.

Luise, Nicola; Wyatt, Eleanor W.; Tarver, Gary J.; Wyatt, Paul G. published the artcile< A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments>, Electric Literature of 93247-78-0, the main research area is semisatd heterobicycle preparation hydrogenation.

An efficient hydrogenation protocol under continuous flow conditions was developed for the synthesis of underrepresented semi-saturated bicyclic fragments containing highly sp3-rich skeletons for fragment-based drug discovery (FBDD) programs. Excellent yields were generally achieved by using Pd/C (10% weight/weight) and RaNi at 25-150° under 4-100 bar of hydrogen pressure. The generated fragments, with appropriate physicochem. properties, present diverse hydrogen-bonding pharmacophores and useful vectors for their synthetic elaboration in the optimization stage. Successive, simple functionalizations in continuous flow were accomplished to demonstrate the opportunity to develop multi-step continuous flow synthesis of valuable starting points for FBDD campaigns. A conclusive quality control (QC) was essential to discard those structures which do not fit the typical fragment library parameters.

Banerjee, Sovan Lal’s team published research in Journal of Colloid and Interface Science in 2021-05-31 | 950846-89-6

Journal of Colloid and Interface Science published new progress about Antifouling agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application In Synthesis of 950846-89-6.

Banerjee, Sovan Lal; Saha, Pabitra; Ganguly, Ritabrata; Bhattacharya, Koushik; Kalita, Uddhab; Pich, Andrij; Singha, Nikhil K. published the artcile< A dual thermoresponsive and antifouling zwitterionic microgel with pH triggered fluorescent ""on-off"" core>, Application In Synthesis of 950846-89-6, the main research area is thermoresponsive antifouling zwitterionic microgel fluorescence; Antifouling; Dual thermoresponsiveness; Fluorescence; LSCT; Microgel; UCST; Zwitterion.

A unique, tailor-made, zwitterionic, dual thermoresponsive and fluorescent microgel probe was synthesized via Reversible Addition Fragmentation chain-Transfer (RAFT) polymerization Microgels were prepared via oil in water (o/w) emulsion polymerization where poly(carboxybetaine) (PCB) acted as a macro-RAFT reagent as well as an emulsifier. The presence of poly(N-vinylcaprolactam) (PNVCL) in the microgel system imparts the thermoresponsiveness to the system and the presence of a rhodamine derivative as fluorophore makes it responsive to pH change of the system by showing a fluorescence emission at 580 nm (reddish orange color). The dual thermoresponsiveness [i.e. the presence of upper critical solution temperature (UCST @ 12°C) as well as lower critical solution temperature (LCST @ 33°C)] of the microgels was studied via UV-visible spectroscopy (UV-vis) and temperature responsive dynamic light scattering (DLS) analyses. Presence of the PCB in the corona-crosslinked microgel, played a vital role in the formation of self-assembled structure as well as in protein immobilization (antifouling activity). Antifouling property was studied using UV-vis spectroscopy where bovine serum albumin (BSA) was taken as a model protein. The presence of the pH-responsive fluorescence, thermoresponsiveness as well as antifouling properties makes this zwitterionic microgel system a potential a potential candidate for medical diagnostics and for drug delivery vehicles.

Zhang, Ting-Yu’s team published research in Organic Letters in 2018-01-05 | 23077-43-2

Organic Letters published new progress about Cyclization. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Category: indole-building-block.

Zhang, Ting-Yu; Liu, Chang; Chen, Chao; Liu, Jian-Xin; Xiang, Heng-Ye; Jiang, Wei; Ding, Tong-Mei; Zhang, Shu-Yu published the artcile< Copper-Mediated Cascade C-H/N-H Annulation of Indolocarboxamides with Arynes: Construction of Tetracyclic Indoloquinoline Alkaloids>, Category: indole-building-block, the main research area is tetracyclic indoloquinoline alkaloid preparation cascade annulation.

An efficient and environmentally benign Cu-mediated method was developed for direct cascade C-H/N-H annulation to construct polyheterocyclic indoloquinoline scaffolds (e.g. I). This method highlights an emerging strategy for transforming inert C-H bonds into versatile functional groups in organic synthesis and provides a new versatile approach for the efficient synthesis of indolo[3,2-c] and [2,3-c]quinoline alkaloids.

Organic Letters published new progress about Cyclization. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Category: indole-building-block.

Lu, Wen-Jun’s team published research in Acta Crystallographica, Section E: Structure Reports Online in 2012-01-31 | 23077-43-2

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Name: 5-Fluoro-1H-indole-3-carboxylic acid.

Lu, Wen-Jun; Zou, Zhi-Hong; Luo, Yang-Hui published the artcile< 5-Fluoro-1H-indole-3-carboxylic acid>, Name: 5-Fluoro-1H-indole-3-carboxylic acid, the main research area is crystal structure fluoroindolecarboxylic acid; mol structure fluoroindolecarboxylic acid; hydrogen bond fluoroindolecarboxylic acid; indolecarboxylic fluoro acid crystal mol structure.

In 5-fluoro-1H-indole-3-carboxylic acid, C9H6FNO2, the carboxyl group is twisted slightly away from the indole-ring plane [dihedral angle = 7.39(10)°]. In the crystal, carboxyl inversion dimers linked by pairs of O-H···O H bonds generate R22(8) loops and N-H···O H bonds connect the dimers into (101̅) sheets. Crystallog. data are given.

Kufareva, Irina’s team published research in Scientific Reports in 2019-12-31 | 23077-43-2

Scientific Reports published new progress about Apoptosis. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Reference of 23077-43-2.

Kufareva, Irina; Bestgen, Benoit; Brear, Paul; Prudent, Renaud; Laudet, Beatrice; Moucadel, Virginie; Ettaoussi, Mohamed; Sautel, Celine F.; Krimm, Isabelle; Engel, Matthias; Filhol, Odile; Borgne, Marc Le; Lomberget, Thierry; Cochet, Claude; Abagyan, Ruben published the artcile< Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors>, Reference of 23077-43-2, the main research area is CK2 inhibitor cell growth apoptosis breast cancer.

CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2a and CK2β subunits is essential for substrate selectivity. The CK2a/CK2β interface has been previously targeted by peptides to achieve functional effects; however, no small mols. modulators were identified due to pocket flexibility and open shape. Here we generated numerous plausible conformations of the interface using the fumigation modeling protocol, and virtually screened a compound library to discover compound 1 that suppressed CK2a/CK2β interaction in vitro and inhibited CK2 in a substrate-selective manner. Orthogonal SPR, crystallog., and NMR experiments demonstrated that 4 and 6, improved analogs of 1, bind to CK2a as predicted. Both inhibitors alter CK2 activity in cells through inhibition of CK2 holoenzyme formation. Treatment with 6 suppressed MDA-MB231 triple neg. breast cancer cell growth and induced apoptosis. Altogether, our findings exemplify an innovative computational-exptl. approach and identify novel non-peptidic inhibitors of CK2 subunit interface disclosing substrate-selective functional effects.

Scientific Reports published new progress about Apoptosis. 23077-43-2 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Reference of 23077-43-2.

DeRatt, Lindsey G’s team published research in Organic Letters in 2019-12-06 | 399-76-8

Organic Letters published new progress about Heterocyclic compounds, nitrogen Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 399-76-8 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Application of C9H6FNO2.

DeRatt, Lindsey G.; Lawson, Edward C.; Wang, Chao-Yuan; Kuduk, Scott D. published the artcile< Mild Intramolecular Ring Opening of Oxetanes>, Application of C9H6FNO2, the main research area is oxetane carboxamide nucleophile intramol ring opening.

Herein, an intramol. ring opening of oxetane carboxamides with mild nucleophiles, such as nitrogen heterocycles, is presented. The reaction proceeds under metal-free basic conditions which is highly unusual in ring opening reactions of oxetanes. Amide formation and oxetane ring opening/cyclization in a one-pot approach affords high levels of mol. complexity in a single step from simple, readily available substrates.

Kopinathan, Anitha’s team published research in Journal of Medicinal Chemistry in 2019-01-10 | 399-76-8

Journal of Medicinal Chemistry published new progress about Amidation. 399-76-8 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Recommanded Product: 5-Fluoroindole-2-carboxylic acid.

Kopinathan, Anitha; Draper-Joyce, Christopher; Szabo, Monika; Christopoulos, Arthur; Scammells, Peter J.; Lane, J. Robert; Capuano, Ben published the artcile< Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D2 Receptor>, Recommanded Product: 5-Fluoroindole-2-carboxylic acid, the main research area is SB269652 derivative preparation indolecarboxamide motif modification drug design antipsychotics.

SB269652 (I) is a neg. allosteric modulator of the dopamine D2 receptor. Herein, we present the design, synthesis, and pharmacol. evaluation of “”second generation”” analogs of I whereby subtle modifications to the indole-2-carboxamide motif confer dramatic changes in functional affinity (5000-fold increase), cooperativity (100-fold increase), and a novel action to modulate dopamine efficacy. Thus, structural changes to this region of I allows the generation of a novel set of analogs with distinct pharmacol. properties.

Luo, Na’s team published research in Organic Chemistry Frontiers in 2021 | 20870-77-3

Organic Chemistry Frontiers published new progress about Cyclization. 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Name: 4-Chloroindolin-2-one.

Luo, Na; Sun, Zhen-Wei; Xu, Xing-Xin; Hu, Xiao-Qiang; Jia, Feng-Cheng published the artcile< A transition-metal-free, base-promoted annulation/ring-cleavage/ring-reconstruction cascade reaction: a facile access to N-protection free indole-indenones>, Name: 4-Chloroindolin-2-one, the main research area is indole indenone preparation; arylglyoxal oxindole annulation ring cleavage construction cascade.

A one-step, transition-metal-free, base-promoted cascade reaction of 2-halogenated arylglyoxals with 2-oxindoles is reported herein, which provides a straightforward approach to structurally diverse N-protection free indole-indenones in satisfactory yields. Control experiments indicated that the geminal bisindolin-2-one intermediate played a crucial role in the downstream annulation/ring-cleavage/ring-reconstruction reaction sequence. This novel reaction not only further enriches the reactivity of indolin-2-ones as the recursive enolate anion source, but also achieves thermal-induced α-arylation of oxindoles without a transition-metal catalyst.

Organic Chemistry Frontiers published new progress about Cyclization. 20870-77-3 belongs to class indole-building-block, and the molecular formula is C8H6ClNO, Name: 4-Chloroindolin-2-one.

Huang, Xu-Lun’s team published research in Organic Letters in 2020-12-18 | 399-76-8

Organic Letters published new progress about [3+2] Cycloaddition reaction (photochem., stereoselective). 399-76-8 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Product Details of C9H6FNO2.

Huang, Xu-Lun; Cheng, Yuan-Zheng; Zhang, Xiao; You, Shu-Li published the artcile< Photoredox-Catalyzed Intermolecular Hydroalkylative Dearomatization of Electron-Deficient Indole Derivatives>, Product Details of C9H6FNO2, the main research area is indole amino acid diastereoselective hydroalkylation dearomatization photoredox; indoline stereoselective preparation lactamization; lactam fused indoline stereoselective preparation.

Dearomatization of indole derivatives offers a straightforward approach to access diverse indolines. To date, the corresponding dearomative transformations involving electron-deficient indoles are limited. Herein, we report a one-electron strategy for dearomatization of electron-deficient indoles via a photoredox-catalyzed hydroalkylation employing com. available glycine derivatives as the hydrofunctionalization reagents. Followed by DBU-mediated lactamization, structurally appealing lactam-fused indolines are obtained in good to excellent yields with exclusive selectivity.