indole-building-block | - Page 77 of 1434

Li, Fahui et al. published their research in Angewandte Chemie, International Edition in 2015 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.SDS of cas: 146368-07-2

A Covalent Approach for Site-Specific RNA Labeling in Mammalian Cells was written by Li, Fahui;Dong, Jianshu;Hu, Xiaosong;Gong, Weimin;Li, Jiasong;Shen, Jing;Tian, Huifang;Wang, Jiangyun. And the article was included in Angewandte Chemie, International Edition in 2015.SDS of cas: 146368-07-2 This article mentions the following:

Advances in RNA research and RNA nanotechnol. depend on the ability to manipulate and probe RNA with high precision through chem. approaches, both in vitro and in mammalian cells. However, covalent RNA labeling methods with scope and versatility comparable to those of current protein labeling strategies are underdeveloped. A method is reported for the site- and sequence-specific covalent labeling of RNAs in mammalian cells by using tRNA^Ile2-agmatidine synthetase (Tias) and click chem. The crystal structure of Tias in complex with an azide-bearing agmatine analog was solved to unravel the structural basis for Tias/substrate recognition. The unique RNA sequence specificity and plastic Tias/substrate recognition enable the site-specific transfer of azide/alkyne groups to an RNA mol. of interest in vitro and in mammalian cells. Subsequent click chem. reactions facilitate the versatile labeling, functionalization, and visualization of target RNA. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2SDS of cas: 146368-07-2).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ding, Zhenhua et al. published their research in Angewandte Chemie, International Edition in 2013 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Name: 5-Chloroindole-3-carboxaldehyde

Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles was written by Ding, Zhenhua;Yoshikai, Naohiko. And the article was included in Angewandte Chemie, International Edition in 2013.Name: 5-Chloroindole-3-carboxaldehyde This article mentions the following:

The authors developed an intramol. olefin hydroarylation reaction using a cobalt nitrogen-heterocyclic carbene (NHC) as a catalyst. The title compounds thus formed included dihydropyrroloindole derivatives and tetrahydropyridoindole derivatives The synthesis of the target compounds was achieved by a directed carbon-hydrogen bond (C-H bond) activation. Cobalt bromide (CoBr₂), 4,5-dihydro-1,3-bis(2,4,6-trimethylphenyl)-1H-imidazolium chloride (SImes chloride) was used as catalyst combination and [(Trimethylsilyl)methyl]magnesium chloride (Grignard reagent) was used as additive. A cyclization of N-[[1-(3-butenyl)-1H-indol-3-yl]methylene]-4-methoxybenzenamine (I) (indole alkene imine Schiff base) gave a pyrrolo[1,2-a]indolecarboxaldehyde derivative (II) and 6,7,8,9-tetrahydropyrido[1,2-a]indole-10-carboxaldehyde (III). In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Name: 5-Chloroindole-3-carboxaldehyde).

Wang, Lei et al. published their research in Angewandte Chemie, International Edition in 2013 | CAS: 150560-58-0

5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 5-Isopropylindoline-2,3-dione

Palladium-catalyzed oxidative cycloaddition through C-H/N-H activation: access to benzazepines was written by Wang, Lei;Huang, Jiayao;Peng, Shiyong;Liu, Hui;Jiang, Xuefeng;Wang, Jian. And the article was included in Angewandte Chemie, International Edition in 2013.Recommanded Product: 5-Isopropylindoline-2,3-dione This article mentions the following:

A synthesis of benzazepine heterocycles from isatins and alkynes via direct Pd-catalyzed oxidative cycloaddition is developed. Heterocycles are well tolerated in the reaction, which allows access to a number of unique mol. structures. The significance of the benzazepine scaffold as a structural element should render this method attractive for both synthetic and medicinal chem. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Recommanded Product: 5-Isopropylindoline-2,3-dione).

Wang, Le et al. published their research in Organic Letters in 2020 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C10H10BrN

Fe-Catalyzed Sequential C(sp³)-H/N-H Annulation of 2-Methylindoles with Ethyl Trifluoropyruvate at Room Temperature: Construction of Pyrrolo[1,2-婵炵鍋愮€电導ndoles was written by Wang, Le;Zhou, Jia;Chen, Han-Qia;Li, Dong-Li;Lin, Jun-Bing;Li, Ke;Ding, Tong-Mei;Zhang, Shu-Yu. And the article was included in Organic Letters in 2020.Synthetic Route of C10H10BrN This article mentions the following:

An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp³)-H/N-H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a green and practical method for the one-pot rapid synthesis of a wide range of diversely functionalized pyrrolo[1,2-婵炵鍋愮€电導ndoles. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Synthetic Route of C10H10BrN).

Kim, Seung Wook et al. published their research in Angewandte Chemie, International Edition in 2019 | CAS: 754214-56-7

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Category: indole-building-block

Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates was written by Kim, Seung Wook;Schempp, Tabitha T.;Zbieg, Jason R.;Stivala, Craig E.;Krische, Michael J.. And the article was included in Angewandte Chemie, International Edition in 2019.Category: indole-building-block This article mentions the following:

Cyclometallated 闂?allyliridium C,O-benzoates modified with (S)-tol-BINAP, which are stable to air, water, and SiO₂, catalyze highly enantioselective N-allylations of indoles and related azoles. This reaction complements previously reported metal-catalyzed indole allylations in that complete levels of N vs. C3 and branched vs. linear regioselectivity are observed In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7Category: indole-building-block).

Zhao, Shuai et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 112656-95-8

7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Reference of 112656-95-8

Visible-Light-Mediated Cyclopropanation Reactions of 3-Diazooxindoles with Arenes was written by Zhao, Shuai;Chen, Xiang-Xiang;Gao, Nan;Qian, Mingcheng;Chen, Xin. And the article was included in Journal of Organic Chemistry in 2021.Reference of 112656-95-8 This article mentions the following:

The cyclopropanation reaction of 3-diazooxindoles with arenes was first accomplished using visible-light irradiation A series of spiro[norcaradiene-7,3′-indolin]-2′-ones, e.g., I, were synthesized for the first time in high yields and with excellent diastereoselectivities. The synthetic usefulness of this catalyst-free photochem. methodol. is illustrated by the further controllable rearrangement and epoxidation reactions. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Reference of 112656-95-8).

Ichimaru, Yoshimi et al. published their research in Bioorganic & Medicinal Chemistry in 2017 | CAS: 320734-35-8

7-Bromooxindole (cas: 320734-35-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.HPLC of Formula: 320734-35-8

5-Bromoindirubin 3′-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase was written by Ichimaru, Yoshimi;Fujii, Takeshi;Saito, Hiroaki;Sano, Makoto;Uchiyama, Taketo;Miyairi, Shinichi. And the article was included in Bioorganic & Medicinal Chemistry in 2017.HPLC of Formula: 320734-35-8 This article mentions the following:

Indirubin 3′-oxime (Indox I) suppresses cancer cell growth (IC₅₀: 15 濠电偞鎸鹃幏?towards HepG2 cells) and inhibits cell cycle-related kinases such as cyclin-dependent kinases and glycogen synthase kinase-3闁? The authors have previously reported that the conjugation of I with oxirane, a protein-reactive component, enhanced the cytotoxic activity of Indox as determined from the IC₅₀ value (1.7 濠电偞鎸鹃幏? of indirubin 3′-(O-oxiran-2-ylmethyl)oxime (Epox/Ind II). Here the authors prepared Epox/Ind derivatives with one or two halogen atoms or a methoxy group on the aromatic ring(s) of an Indox moiety and studied the structure-activity relationships of the substituent(s). It was found that bromine-substitution at the 5-position on II or any Epox/Ind derivative(s) having bromine on the aromatic ring except Epox/6′-Br-Ind was efficient to improving anticancer activity. Of the 22 Epox/Ind derivatives, 5-bromoindirubin 3′-(O-oxiran-2-ylmethyl)oxime (Epox/5-Br-Ind III) was the best anticancer agent in both short- (24 h) (IC₅₀: 0.67 濠电偞鎸鹃幏? and extended-duration (72 h) cultures. The high anticancer activity of III was partly due to it being a poor substrate and a suicide inhibitor for epoxide hydrolase as epoxide hydrolase was identified as the enzyme primarily responsible for the metabolism of III. In the experiment, the researchers used many compounds, for example, 7-Bromooxindole (cas: 320734-35-8HPLC of Formula: 320734-35-8).

Zhang, Lin-Lin et al. published their research in Organic Letters in 2018 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Category: indole-building-block

Remote Control of Axial Chirality: Synthesis of Spirooxindole-Urazoles via Desymmetrization of ATAD was written by Zhang, Lin-Lin;Zhang, Ji-Wei;Xiang, Shao-Hua;Guo, Zhen;Tan, Bin. And the article was included in Organic Letters in 2018.Category: indole-building-block This article mentions the following:

In the presence of a nonracemic bisthiourea, 3-vinylindoles and N-Boc alkylideneoxindoles underwent diastereoselective and enantioselective tandem Diels-Alder and ene reactions and desymmetrization with triazolinediones in hexane to yield spirooxindolecarbazolylurazoles such as I containing axial chirality in 49-84% yields, 3:1-10:1 dr at the atropisomeric axes, and in 93->99% ee. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Category: indole-building-block).

Zhu, Li-Li et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application of 14204-27-4

N²-Selective 闁?Thioalkylation of Benzotriazoles with Alkenes was written by Zhu, Li-Li;Tian, Lifang;Sun, Kunhui;Li, Yiwen;Liu, Guanglu;Cai, Bin;Zhang, Hui;Wang, Yahui. And the article was included in Journal of Organic Chemistry in 2022.Application of 14204-27-4 This article mentions the following:

Herein, N²-selective 闁?thioalkylation of benzotriazoles with unactivated alkenes and styrenes is reported. The N²-selective 闁?thioalkylation of benzotriazoles is highly stereospecific and works under simple and mild conditions, exhibiting excellent functional group tolerance. The high N²-selectivity is a consequence of the combination of hydrogen bonding and Lewis acid/base activation, which reverses the N²-position to be favored for alkylation. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Application of 14204-27-4).

Yang, Zhen et al. published their research in Chemistry – A European Journal in 2019 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione

Photochemical, metal-free sigmatropic rearrangement reactions of sulfur ylides was written by Yang, Zhen;Guo, Yujing;Koenigs, Rene M.. And the article was included in Chemistry – A European Journal in 2019.Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:

Sigmatropic rearrangement reactions constitute one of the most fundamental reactions of carbenes. While state-of-the-art synthetic methods require the use of expensive precious metal catalysts, the application of visible light for the photolysis of 婵?aryldiazoacetates is much less investigated and provides an operationally simple entry to carbenes under mild reaction conditions. Herein, we report on blue-light induced sigmatropic rearrangement reactions of sulfur compounds with 婵?aryldiazoacetates. This process, depending on the substitution pattern of the sulfide, opens up formal insertion reactions of carbenes into S-N, S-C, or C-H bonds. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione).