indole-building-block | - Page 79 of 1434

Ferro, Noel et al. published their research in Journal of Chemical Information and Modeling in 2006 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Electric Literature of C10H8ClNO2

Coulomb and Overlap Self-Similarities: A Comparative Selectivity Analysis of Structure-Function Relationships for Auxin-like Molecules was written by Ferro, Noel;Gallegos, Ana;Bultinck, Patrick;Jacobsen, Hans-Joerg;Carbo-Dorca, Ramon;Reinard, Thomas. And the article was included in Journal of Chemical Information and Modeling in 2006.Electric Literature of C10H8ClNO2 This article mentions the following:

Auxins are defined mainly by a set of physiol. actions, but the structure-effect relationship still is based on chem. intuition. Currently a well-defined auxin mol. structure is not available. The existence of different auxin binding proteins and mechanisms of auxin action, the wide diversity of the auxin mols., and the pleiotropic effects of auxin imply a completely different mechanism as described for the animal hormone concept. Here, we present a computational approach dealing with semiempirical optimizations of the auxin mols. themselves, which represent a number of about 250 different chem. structures. Our approach uses mol. quantum similarity measures and addnl. quantum variables for the anal. of auxin-like mols. The finding of similarities in mols. by focusing basically on their electron structure results in new insights in the relationship of the different auxin groups. Addnl. statistical anal. allows the identification of relationships between similarity groups and their biol. activity, resp. It is postulated that the auxin-like mol. recognition depends more on specific mol. assembling states than on a specific ring system or side chain. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Electric Literature of C10H8ClNO2).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Laufer, Stefan et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 16732-64-2

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application of 16732-64-2

Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase was written by Laufer, Stefan;Lehmann, Frank. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Application of 16732-64-2 This article mentions the following:

The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNF婵?and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Application of 16732-64-2).

Butcher, Ray J. et al. published their research in Acta Crystallographica, Section E: Structure Reports Online in 2007 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate

Methyl 5-bromo-1H-indole-2-carboxylate was written by Butcher, Ray J.;Jasinski, Jerry P.;Yathirajan, H. S.;Ashalatha, B. V.;Narayana, B.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2007.Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate This article mentions the following:

The indole ring system in Me 5-bromo-1H-indole-2-carboxylate, C₁₀H₈BrNO₂, is planar. The sum of the angles around the indole N atom (359.9闂? indicates sp²-hybridization. The carboxylate group adopts a planar arrangement with respect to the indole ring system. The crystal structure is stabilized by intermol. H-bond interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate).

Cao, Yun-yun et al. published their research in Zhongguo Yaowu Huaxue Zazhi in 2013 | CAS: 774-47-0

5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Related Products of 774-47-0

Synthesis and antitumor activity of novel 6-substituted methylenehydrazinyl-2,4-bismorpholino-pyrimidine and 1,3,5-triazine derivatives was written by Cao, Yun-yun;Zhu, Wu-fu;Zhu, Yan;Guo, Fei;Lu, Xiang-ran;Gong, Ping. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2013.Related Products of 774-47-0 This article mentions the following:

A series of 6-substituted methylenehydrazinyl-2,4-bismorpholino-pyrimidine and 1,3,5-triazine derivatives were synthesized and their chem. structures were confirmed by ¹H-NMR and MS spectra. As the raw materials, 2,4,6-trichloropyrimidine or cyanuric chloride, aniline, benzimidazole and pyrrole were used to obtain the title compounds by multi-step reactions including substitution, cyclization, N-alkylation and Vilsmeier reaction. All the synthesized compounds were evaluated for their antitumor activities against three cancer cell lines (H460, A549 and H226) by the MTT method and BMCL-200908069-1 as the pos. control. Most of the prepared compounds exhibited moderate cytotoxic activities and high selectivity against H460 cancer cell line and A549 compared with the pos. control compound The pharmacol. data indicated that the introduction of substituted aryl methylene group was favorable for increasing the antitumor activity. The most promising compound 6a showed a strong antitumor activity against H460, A549 and H226 cell lines with IC₅₀ values of 3.4濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1, 0.75濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1 and 0.86濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1, which were 2.8 to 16.8 times more active than the pos. control (9.52濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1, 29.24濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1, 36.21濠电偞鎸鹃幐绱€l闁荤姾娅ｉ弸?sup>-1), resp. Further studies are currently underway and will be reported in the future. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Related Products of 774-47-0).

Alvarez, Estela et al. published their research in Chemistry – A European Journal in 2015 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 6-Nitro-1H-indole

Bronsted Acid-Catalyzed Cascade Reactions Involving 1,2-Indole Migration was written by Alvarez, Estela;Nieto Faza, Olalla;Silva Lopez, Carlos;Fernandez-Rodriguez, Manuel A.;Sanz, Roberto. And the article was included in Chemistry – A European Journal in 2015.Recommanded Product: 6-Nitro-1H-indole This article mentions the following:

A cascade reaction of indoles with propargylic diols involving an unprecedented metal-free 1,2-indole migration onto an alkyne was carried out. DFT calculations support a mechanism consisting of a concerted nucleophilic attack of the indole nucleus with loss of water, followed by the 1,2-migration and subsequent Nazarov cyclization. This Bronsted acid-catalyzed protocol affords indole-functionalized benzofulvene derivatives in high yields. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Recommanded Product: 6-Nitro-1H-indole).

Li, Dingzhong et al. published their research in Catalysis Communications in 2022 | CAS: 4769-96-4

6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C8H6N2O2

Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes was written by Li, Dingzhong;Lu, Hao;Yang, Tianbao;Xing, Chen;Sun, Tulai;Fu, Lihua;Qiu, Renhua. And the article was included in Catalysis Communications in 2022.Synthetic Route of C8H6N2O2 This article mentions the following:

An industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes was reported. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate could be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol featured cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity). In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Synthetic Route of C8H6N2O2).

Matsuoka, Masaru et al. published their research in Shikizai Kyokaishi in 1976 | CAS: 24407-32-7

4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 24407-32-7

A method to lower the degree of halogenation of polyhalogenated pigments was written by Matsuoka, Masaru;Kitao, Teijiro. And the article was included in Shikizai Kyokaishi in 1976.HPLC of Formula: 24407-32-7 This article mentions the following:

In both pigment systems I and II (Z = p-C6H4, p-C6H4C6H4-p) a benzo substituent on both aromatic rings was intermediate between 4 Cl and 4 Br substituents in its effect on increasing the thermal stability as determined by thermogravimetry. Thus, annellation can be considered as an alternative to halogenation to prepare pigments with greater heat resistance, avoiding the toxicity problems associated with polychloro aromatic compounds In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7HPLC of Formula: 24407-32-7).

Lu, Lin et al. published their research in Organic Letters in 2019 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Safety of 5-Chloroindole-3-carboxaldehyde

Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO₃ was written by Lu, Lin;Luo, Chenguang;Peng, Hui;Jiang, Huanfeng;Lei, Ming;Yin, Biaolin. And the article was included in Organic Letters in 2019.Safety of 5-Chloroindole-3-carboxaldehyde This article mentions the following:

A variety of structurally novel polycyclic sulfonyl indolines were synthesized via FeCl₂-catalyzed or UV-driven intramol. formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methylpropiolamides with NaHSO₃ in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Safety of 5-Chloroindole-3-carboxaldehyde).

Graybill, Todd L. et al. published their research in Journal of the American Chemical Society in 1999 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Related Products of 14204-27-4

Silyl Triflate-Mediated Ring-Closure and Rearrangement in the Synthesis of Potential Bisfuran-Containing Intermediates of Aflatoxin Biosynthesis was written by Graybill, Todd L.;Casillas, Eduard G.;Pal, Kollol;Townsend, Craig A.. And the article was included in Journal of the American Chemical Society in 1999.Related Products of 14204-27-4 This article mentions the following:

The biosynthetic pathway to the potent mycotoxin aflatoxin B₁ (I) is unusually long and complex, proceeding from anthraquinone to xanthone to coumarin nuclear types bearing fused tetrahydro- and bisdihydrofuran rings. A synthetic strategy is described involving two silyl triflate-mediated cyclization and rearrangement processes that have enabled both furofuran oxidation states to be readily achieved and undesired but thermodynamically favorable side reactions to be avoided in the preparation of these ring systems. In the first an o-methoxymethylphenylacetaldehyde is cyclized directly to the five-membered, differentially protected hemiacetal, while in the second this group, appropriately substituted, can be rearranged to a 4-trialkylsilyloxy-2,5-methano-1,3-benzodioxepane. The latter masked dialdehyde is sufficiently stable to strong base, mild acid, and oxidants to allow all needed aryl ring systems to be constructed. Using these methods, total syntheses of (闂?-versicolorin B (II), (闂?-versicolorin A (III), its hemiacetal, and its 6-deoxy derivative, (闂?-6-deoxyversicolorin A, have been achieved, and these are reported herein, as well as preparation of the Me ester of the putative o-carboxybenzophenone biosynthetic intermediate IV. In work described elsewhere, incorporation experiments with ¹³C-labeled forms of these compounds have made possible the complete elucidation of bisfuran biosynthesis characteristic of the first major phase of aflatoxin formation in vivo. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Related Products of 14204-27-4).

Yu, Zhengkun et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 1998 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Safety of 2-(Phenylthio)isoindoline-1,3-dione

Reductive desulfurization of organosulfur compounds with sodium in liquid ammonia was written by Yu, Zhengkun;Verkade, John G.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 1998.Safety of 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:

Greater than 95% sulfur removal was observed when dialkyl mono- or polysulfides were treated with Na in liquid ammonia. Polycyclic aromatic sulfur heterocycles were only moderately desulfurized under these conditions while phenylthio derivatives gave thiophenol as the major product and dithiophenols as the minor products. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Safety of 2-(Phenylthio)isoindoline-1,3-dione).