Category: indole-building-block

An article Chloro and bromo-pyrazole curcumin Knoevenagel condensates augmented anticancer activity against human cervical cancer cells: design, synthesis, in silico docking and in vitro cytotoxicity analysis WOS:000505521900015 published article about NF-KAPPA-B; DRUG-DELIVERY; CHITOSAN MICROSPHERES; ANALOGS; INHIBITION; ACTIVATION; APOPTOSIS; MELANOMA; BETA; IKK in [Chaudhary, Monika] IK Gujral Punjab Tech Univ, Jalandhar, Punjab, India; [Chaudhary, Monika] Hindu Coll Pharm, Dept Med Chem, Sonepat, India; [Kumar, Neeraj; Chandra, Ramesh] Univ Delhi, Dept Chem, Delhi, India; [Baldi, Ashish] Maharaja Ranjit Singh Punjab Tech Univ, Dept Pharmaceut Sci & Technol, Bathinda, India; [Chandra, Ramesh] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi, India; [Babu, M. Arockia; Madan, Jitender] Chandigarh Coll Pharm, Dept Pharmaceut, Mohali 140307, Punjab, India in 2020.0, Cited 41.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

With an endeavor to develop novel curcumin analogs as potential anti-cancer agents, we designed and synthesized a series of Knoevenagel condensates by clubbing pyrazole carbaldehydes at the active methylene carbon atom of the curcumin backbone. Molecular docking studies were carried out to target the proposed derivatives on human kinase beta (IKK beta), a potential anti-cancer target. The chloro derivative displayed five hydrogen bond interactions with a docking score of -11.874 kcal/mol higher than curcumin (docking score = -7.434 kcal/mol). This was supported by the fact that the propellant shaped derivatives fitted aptly into the binding pocket. Molecular simulations studies were also conducted on the lead molecule and the results figured out that the stable complexes were developed as the minimal deviations per residue of protein within the range of 0.11-0.92 angstrom. The screened compounds were synthesized, characterized and evaluated in vitro for cytotoxicity against cervical cancer cell line, HeLa using standard cell proliferation assay. Chloro derivative and bromo analog demonstrated IC50 (half maximal inhibitory concentration) value of 14.2 and 18.6 mu g/ml, respectively, significantly lower than 42.4 mu g/ml of curcumin and higher than 0.008 mu g/ml of paclitaxel. Induction of apoptosis was evaluated in the terms of cleavage of caspase-3 enzyme and they also exhibited 69.6 and 65.4% of apoptosis significantly higher than 19.9% induced by curcumin. In conclusion, chloro and bromo derivatives must be evaluated under a set of stringent in vitro and in vivo parameters for translating in to a clinically viable product. Communicated by Ramaswamy H. Sarma

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Chaudhary, M; Kumar, N; Baldi, A; Chandra, R; Babu, MA; Madan, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Fabrication of mesoporous SiO2/Au/Co3O4 hollow spheres catalysts with core-shell structure for liquid phase oxidation of benzyl alcohol to benzaldehyde WOS:000486134100014 published article about HIGHLY SELECTIVE OXIDATION; SOLVENT-FREE OXIDATION; FREE AEROBIC OXIDATION; SUPPORTED NANO-GOLD; MOLECULAR-OXYGEN; HYDROGEN-PEROXIDE; AU NANOPARTICLES; CARBON NITRIDE; PALLADIUM; METAL in [Yuan, Shenhao; Lv, Xushuai; Zhang, Yiwei; Wu, Yangjin; Mao, Chunfeng; Zhou, Yuming; Chen, Wenxia; Wang, Yanyun] Southeast Univ, Sch Chem & Chem Engn, Jiangsu Optoelect Funct Mat & Engn Lab, Nanjing 211189, Jiangsu, Peoples R China in 2019.0, Cited 58.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Quality Control of Benzyl Alcohol

A core-shell structure Au-based catalysts mSiO(2)/Au/Co3O4-HS were successfully derived from in-situ growth ZIF-67 hollow spheres, which were synthesized by a one-step soft template method. The samples were characterized by SEM, TEM, EDX, XPS, XRD and BET to confirm its successful preparation and structural features. The catalytic performance of the catalysts were evaluated by liquid phase oxidation of benzyl alcohol to benzaldehyde with O-2 as the oxidant under alkaline conditions. The experimental results illustrated that reaction conditions, including effect of catalyst amount, oxygen flow rate, reaction temperature and reaction time, were optimized to be 40 mg, 50 ml/min, 140 degrees C and 5 h, respectively. Meanwhile, 55% conversion of benzyl alcohol and 84% selectivitiy to benzaldehyde together with the excellent reusability and stability were achieved under optimal reaction conditions, which was attributed to the core-shell structure leading to the encapsulation of Au NPs and provision of multiple active reaction interface. Based on the intermediates formed from the de-protonation of substrate, a plausible oxidation reaction mechanism with mSiO(2)/Au/Co3O4 -HS catalysts was tentatively proposed to study the relationship between structure and catalytic performance. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Yuan, SH; Lv, XS; Zhang, YW; Wu, YJ; Mao, CF; Zhou, YM; Chen, WX; Wang, YY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Photoinduced hydroxylation of arylboronic acids with molecular oxygen under photocatalyst-free conditions published in 2019. SDS of cas: 98-17-9, Reprint Addresses Zhou, YB; Liu, MC (corresponding author), Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Photoinduced hydroxylation of boronic acids with molecular oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcohols in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Xu, YT; Li, CY; Huang, XB; Gao, WX; Zhou, YB; Liu, MC; Wu, HY or concate me.. SDS of cas: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 J MOL STRUCT published article about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN in [da Silva, Aline Alves; Valle, Marcelo Siqueira] Univ Fed Sao Joao Del Rei, Dept Ciencias Nat, BR-36301160 Sao Joao Del Rei, MG, Brazil; [Maia, Pedro Ivo da Silva] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, USP, FCFRP, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque] Ctr Univ Estacio Ribeirao Preto, Abraao Issa Halach St 980, BR-14096160 Ribeirao Preto, SP, Brazil in 2021, Cited 28. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 J ORG CHEM published article about SIDEROPHORE BIOSYNTHESIS; NUCLEOSIDE ANTIBIOTICS; ARYL FLUOROSULFONATES; MECHANISM; FLUORIDE; ACYLTRANSFERASE; TUBERCULOSIS; ASCAMYCIN; PHENOLS; TARGET in [Gilles, Philippe; Veryser, Cedrick; Vangrunderbeeck, Sarah; Ceusters, Sam; De Borggraeve, Wim M.] Katholieke Univ Leuven, Dept Chem, Mol Design & Synth, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium; [Van Meervelt, Luc] Katholieke Univ Leuven, Dept Chem, Biochem Mol & Struct Biol, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium in 2019, Cited 34. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Recommanded Product: 98-17-9

A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gilles, P; Veryser, C; Vangrunderbeeck, S; Ceusters, S; Van Meervelt, L; De Borggraeve, WM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. In 2019.0 CATAL LETT published article about MULTICOMPONENT REACTION; PALLADIUM; NANOPARTICLES; 3-COMPONENT; GENERATION; PD in [Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam] Ilam Univ, Dept Chem, Fac Sci, POB 69315516, Ilam, Iran in 2019.0, Cited 39.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

In the present study, peptide nanofiber was used to immobilize zinc oxide. This nanoparticle was prepared through self-assembly in an aqueous solution. The structural properties of the prepared catalyst were examined by a series of techniques, such as FT-IR, EDS, SEM, TEM, XRD, ICP-OES (inductively coupled plasma optical emission spectrometry), and ultraviolet-visible (UV-Vis) spectroscopy. TEM images showed the necklace model for peptide nanofiber decorated with zinc oxide. The versatility of the method was investigated by N-arylation using reaction of amines with hydroxybenzotriazole as a novel phenylating reagent, one-pot synthesis of imidazoheterocycles by a three-component reaction of 2-aminopyridine, aldehyde, terminal alkyne and preparation of tetracyclic quinazolinone ring by one-pot reaction of isatoic anhydride, amine, and ninhydrin. High yields, low cost of catalyst, environmental friendliness, efficient recovery and recyclability of catalyst are the most important features of this catalytic system. [GRAPHICS] .

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Taherinia, Z; Ghorbani-Choghamarani, A; Hajjami, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Selective functionalisation of aromatic alcohols with supramolecularly regulated gold(i) catalysts published in 2020.0. Formula: C7H8O2, Reprint Addresses Vidal-Ferran, A (corresponding author), Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain.; Vidal-Ferran, A (corresponding author), Univ Barcelona, Dept Inorgan & Organ Chem, Sect Inorgan Chem, Carrer Marti i Franques 1-11, Barcelona 08028, Spain.; Vidal-Ferran, A (corresponding author), ICREA, Pg Lluis Co 23, Barcelona 08010, Spain.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Phosphite-based Au(i) catalytic systems containing an array of structurally diverse polyether-based regulation sites were designed and synthesised. These catalysts have been successfully tested in the Au(i)-catalysed C-H functionalisation of phenols and related derivatives with gold-carbenes derived from diazo compounds. Regulation of the steric congestion around the catalytic Au(i) centreviaion-dipole interactions with an external regulation agent led to an enhancement of both the activity and selectivity of the reaction. This new approach in supramolecular gold(i) catalysis has been applied to the derivatisation of an array of substituted phenols and related substrates and to the preparation of an advanced synthetic intermediate of the anticancer agent tamoxifen. The effects of the regulation agent on the selectivity and yield of the reaction have been studied and rationalised using DFT-D calculations.

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Carreras, L; Franconetti, A; Grabulosa, A; Frontera, A; Vidal-Ferran, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Py-GC/MS analysis on product distribution of two-staged biomass pyrolysis WOS:000457854800007 published article about BIO-OIL; TG-FTIR; CELLULOSE; LIGNIN; TEMPERATURE; MECHANISM; TORREFACTION; SEPARATION; QUALITY in [Cai, Wenwen; Liu, Qian; Shen, Dekui; Wang, Jingzhen] Southeast Univ, Key Lab Energy Thermal Convers & Control, Sch Energy & Environm, Minist Educ, Nanjing 210096, Jiangsu, Peoples R China in 2019.0, Cited 31.0. Product Details of 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Two-staged pyrolysis of biomass was proposed as a promising method by which liquid products would be less diverse and more concentrated, and beneficial to further upgrading or extracting chemicals. Rice straw, cedar wood, and dalbergia wood were selected as representative biomass materials. Thermogravimetric Fourier-transform infrared spectroscopy (TG-FTIR) was initially used to analyze biomass and the three main components. According to the pyrolysis characteristics and the volatile release processes, 270-360 degrees C was selected as the optional temperature range for the low-temperature stage of the two-staged pyrolysis. Then, Pyrolysis Gas Chromatography Mass Spectrometry (Py-GC/MS) was used in two stages to analyze three types of biomass, with the first stage at 270 degrees C, 320 degrees C, or 360 degrees C and then the second stage at 550 degrees C. The two-staged pyrolysis could efficiently separate biomass pyrolysis products, especially the enrichment of organic acids, alcohols, and aldehydes in the first stage, and the enrichment of phenolic substances in the second stage. The optimum temperature of the first stage was 320 degrees C, which was suitable for three different kinds of biomass.

Product Details of 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Cai, WW; Liu, Q; Shen, DK; Wang, JZ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 RSC ADV published article about TOPOISOMERASE-I INHIBITION; ANTIPROLIFERATIVE ACTIVITY; ANTITUMOR-ACTIVITY; BENZIMIDAZOLES; CYTOTOXICITY; DOCKING in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam in 2020.0, Cited 36.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.. Recommanded Product: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Malasala, Satyaveni; Akunuri, Ravikumar; Madhavi, Y., V; Nanduri, Srinivas] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, Telangana, India; [Ahmad, Md Naiyaz; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India; [Ahmad, Md Naiyaz; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] AcSIR, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2021.0, Cited 58.0. Computed Properties of C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Owing to the rapid rise in antibiotic resistance, infectious diseases have become serious threat to public health. There is an urgent need to develop new antimicrobial agents with diverse chemical structures and novel mechanisms of action to overcome the resistance. In recent years, Quinazoline-benzimidazole hybrids have emerged as a new class of antimicrobial agents active against S. aureus and M. tuberculosis. In the current study, we designed and synthesized fifteen new Quinazoline-benzimidazole hybrids and evaluated them for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine potent antibacterial agents 8a, 8b, 8c, 8d, 8f, 8g, 8h, 8i and 10c with MICs in the range of 4-64 mu g/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clinical isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC50 = 40->= 200 mu g/mL) and demonstrated a favourable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives have emerged as promising antimicrobial agents for the treatment of MDR-S. aureus and Mycobacterial infections. (C) 2020 Elsevier Masson SAS. All rights reserved.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles