Authors Chung, EP; Wells, AR; Kiamco, MM; Leung, KP in SPRINGER published article about DIFFERENTIATION; PROLIFERATION; DECREASES; MIGRATION; ADHESION; INSIGHTS; INJURY; SIZE in [Chung, Eugene P.; Wells, Adrienne R.; Kiamco, Mia Mae; Leung, Kai P.] US Army, Inst Surg Res, Combat Wound Repair Div, Jbsa Ft Sam Houston, TX 78234 USA in 2020.0, Cited 58.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
This study used dual asymmetric centrifugation (DAC) to produce a topical vehicle for Pirfenidone (Pf; 5-methyl-1-phenyl-2[1H]-pyridone)-a Food and Drug Administration-approved antifibrotic drug indicated for idiopathic fibrosis treatment. Pf was loaded (8 wt%) in a poloxamer nanoemulsion gel (PNG) formulation consisting of water (47.8 wt%), triacetin (27.6 wt%), poloxamer 407 (P407, 13.8 wt%), polysorbate 80 (1.8 wt%), and benzyl alcohol (0.9 wt%). To our knowledge, poloxamer gels are typically processed with either high-shear methods or temperature regulation and have not been emulsified using DAC. Using a single-step emulsification process, 2 min mixed at 2500 RPM resulted in the lowest Pf loading variability with a relative standard deviation (RSD) of 0.96% for a 1.5 g batch size. Batch sizes of 15 g and 100 g yield higher RSD of 4.18% and 3.05%, respectively, but still in compliance with USP guidelines.Ex vivopermeation in full thickness porcine skin after 24 h showed total Pf permeation of 404.90 +/- 67.07 mu g/cm(2). Testedin vitroon human dermal fibroblasts stimulated with transforming growth factor-beta 1 (TGF-beta 1), Pf-PNG resulted in a > 2 fold decrease in alpha-SMA expression over vehicle control demonstrating that formulated Pf retained its biological activity. One-month stability testing at 25 degrees C/60% relative humidity (RH) and 40 degrees C/75% RH showed that % drug content, release kinetics, and biological activity were largely unchanged for both conditions; however, pH decreased from 6.7 to 5.5 (25 degrees C/60% RH) and 4.5 (40 degrees C/75% RH) after 1 month. Overall, these data demonstrate the utility of DAC to rapidly and reproducibly prepare lab-scale batches of emulsified gels for pharmaceutical formulation development.
HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Chung, EP; Wells, AR; Kiamco, MM; Leung, KP or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles