Recently I am researching about SULFINIC ACIDS ALDEHYDE; IN-SITU GENERATION; MULTICOMPONENT REACTIONS; AMIDO SULFONES; MANNICH CONDENSATION; ETHYL CARBAMATE; INHIBITORS; PRECURSORS; NITRILES; IMINES, Saw an article supported by the Fund for Scientific Research-Flanders (FWO-Vlaanderen)FWO. Formula: C8H8O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Goncalves, P; Peeraer, A; Adriaenssens, Y; Zonnekein, L; Franck, P; Maes, BUW; Augustyns, K; Van der Veken, P. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde
The Strecker reaction is a three-component condensation of an aldehyde, an amine, and hydrogen cyanide, delivering an a-amino carbonitrile. Despite extensive investigations, the possibility to use amides instead of amines as one of the three condensation partners has been largely neglected. Nonetheless, the N-acylated alpha-aminocarbonitriles that are obtained in this way are of direct interest for drug discovery, because they make up a well-known class of mechanism-based inhibitors of serine- and cysteine-type hydrolases. In response, we have thoroughly explored the corresponding variant of the Strecker reaction, focusing on catalyst use, solvent, reaction time, and cyanide source. Optimized parameters were combined in a sequential one-pot protocol for which the scope was found to be compatible with library synthesis applications. Product yields ranged from 7 to 90%, and conditions were found to be mild and tolerant to a wide range of functional groups, including moieties that are typically present in druglike molecules.
Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Goncalves, P; Peeraer, A; Adriaenssens, Y; Zonnekein, L; Franck, P; Maes, BUW; Augustyns, K; Van der Veken, P or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles