Recently I am researching about ONE HUNDRED YEARS; STEREOSELECTIVE SYNTHESES; ENANTIOMERICALLY PURE; STRUCTURAL-PROPERTIES; HELICAL QUINONE; OXAHELICENES; ROUTE, Saw an article supported by the Institute of Organic Chemistry and Biochemistry (IOCB), Czech Academy of Sciences [RVO: 61388963]; IOCB postdoctoral program; Henry Dreyfus Teacher-Scholar Award. Product Details of 150-76-5. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Sundar, MS; Klepetarova, B; Bednarova, L; Muller, G. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol
Herein, we report a simple and efficient approach to synthesize a functionalized 2,18-dimethoxy-5,10,15-trioxa[9]helicene. It was synthesized from simple phenol building blocks using two subsequent reactions namely oxidative coupling and dehydrative cyclization or palladium mediated cyclization. The molecular integrity of the helical core was determined by single-crystal X-ray diffraction and NMR techniques. Its crystal structure showed the spontaneous resolution which was attributed to the conglomerate formation of the same helical isomer via C-H…O and pi…pi or H…pi interactions. Then, it was converted to racemic 2,18-dihydoxy-5,10,15-trioxa[9]helicene. Enantiomers were separated on preparative HPLC with high optical purity (>99 % ee). Based on electronic circular dichroism, the absolute configurations of dextrorotary and levorotatory antipodes were assigned as P and M, respectively. We also studied the absorption, emission and chiroptical behavior of these helical compounds in the solution state.
Product Details of 150-76-5. About Mequinol, If you have any questions, you can contact Sundar, MS; Klepetarova, B; Bednarova, L; Muller, G or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles