An article A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism WOS:000507146000010 published article about STREPTOCOCCUS-MUTANS; INSPIRED ANALOGS; DENTAL-CARIES; MAGNOLOL; BIOFILM in [Ochoa, Cristian; Nowlan, Marcus; Kozlowski, Marisa C.] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA; [Solinski, Amy E.; Dekarske, Madeline M.; Wuest, William M.] Emory Univ, Dept Chem, 1515 Dickey Dr, Atlanta, GA 30322 USA; [Solinski, Amy E.; Dekarske, Madeline M.; Wuest, William M.] Emory Univ, Emory Antibiot Resistance Ctr, 1515 Dickey Dr, Atlanta, GA 30322 USA in 2020.0, Cited 29.0. HPLC of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ochoa, C; Solinski, AE; Nowlan, M; Dekarske, MM; Wuest, WM; Kozlowski, MC or concate me.. HPLC of Formula: C7H6O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles