Computed Properties of C7H6O2. In 2020.0 BIOORG MED CHEM LETT published article about ANTIFUNGAL; LIPOPHILICITY in [Stingaci, Eugenia; Zveaghinteva, Marina; Pogrebnoi, Serghei; Lupascu, Lucian; Macaev, Fliur] Inst Chem, Lab Organ Synth & Biopharmaceut, 3 Str Acad, Kishinev, Moldova; [Valica, Vladimir; Uncu, Livia; Smetanscaia, Anastasia; Drumea, Maricica; Macaev, Fliur] Nicolae Testemitanu State Univ Med & Pharm, Sci Ctr Drug Res, Kishinev, Moldova; [Petrou, Anthi; Geronikaki, Athina] Aristotle Univ Thessaloniki, Dept Pharm, Sch Hlth, Thessaloniki 54124, Greece; [Ciric, Ana; Glamoclija, Jasmina; Sokovic, Marina] Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovic, Dept Plant Physiol, Bulevar Despota Stefana 142, Belgrade 11000, Serbia; [Kravtsov, Victor] Inst Appl Phys, Lab Phys Methods Solid State Invest Tadeusz Malin, 5 Str Acad, Kishinev, Moldova in 2020.0, Cited 23.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.
1,2,4-Triazole is a very important scaffold in medicinal chemistry due to the wide spectrum of biological activities and mainly antifungal activity of 1,2,4-triazole derivatives. The main mechanism of antifungal action of the latter is inhibition of 14-alpha-demethylase enzyme (CYP51). The current study presents synthesis and evaluation of eight triazole derivatives for their antimicrobial activity. Docking studies to elucidate the mechanism of action were also performed. The designed compounds were synthesized using classical methods of organic synthesis. The in vivo evaluation of antimicrobial activity was performed by microdilution method. All tested compounds showed good antibacterial activity with MIC and MBC values ranging from 0.0002 to 0.0069 mM. Compound 2 h appeared to be the most active among all tested with MIC at 0.0002-0.0033 mM and MBC at 0.0004-0.0033 mM followed by compounds 2f and 2g. The most sensitive bacterium appeared to be Xanthomonas campestris while Erwinia amylovora was the most resistant. The evaluation of antifungal activity revealed that all compounds showed good antifungal activity with MIC values ranging from 0.02 mM to 0.52 mM and MFC from 0.03 mM to 0.52 mM better than reference drugs ketoconazole (MIC and MFC values at 0.28-1.88 mM and 0.38 mM to 2.82 mM respectively) and bifonazole (MIC and MFC values at 0.32-0.64 mM and 0.64-0.81 mM). The best antifungal activity is displayed by compound 2 h with MIC at 0.02-0.04 mM and MFC at 0.03-0.06 mM while compound 2a showed the lowest activity. The results showed that these compounds could be lead compounds in search for new potent antimicrobial agents. Docking studies confirmed experimental results.
Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Stingaci, E; Zveaghinteva, M; Pogrebnoi, S; Lupascu, L; Valica, V; Uncu, L; Smetanscaia, A; Drumea, M; Petrou, A; Ciric, A; Glamoclija, J; Sokovic, M; Kravtsov, V; Geronikaki, A; Macaev, F or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles