Category: indole-building-block. Authors Yagiz, G; Noma, SAA; Altundas, A; Al-khafaji, K; Taskin-Tok, T; Ates, B in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Yagiz, Guler; Altundas, Aliye] Gazi Univ, Fac Sci, Dept Chem, TR-06500 Ankara, Turkey; [Noma, Samir Abbas Ali; Ates, Burhan] Inonu Univ, Dept Chem, Fac Sci & Arts, TR-44280 Malatya, Turkey; [Al-khafaji, Khattab; Taskin-Tok, Tugba] Gaziantep Univ, Dept Chem, Fac Arts & Sci, TR-27310 Gaziantep, Turkey; [Taskin-Tok, Tugba] Gaziantep Univ, Inst Hlth Sci, Dept Bioinformat & Computat Biol, TR-27310 Gaziantep, Turkey in 2021, Cited 48. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
This study focused on synthesis various dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives under the conditions of green chemistry without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25 mu M. Especially, (1-(3-bromobenzyl)-1H-1,2,3-triazole-4,5-diyl)dimethanol (5c) and dimethyl 1-(4-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate (6 g) compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73 mu M, respectively. Moreover, the double docking procedure was to evaluate compound modes of inhibition and their interactions with the protein (XO) at atomic level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R-2 = 0.7455)]. Also, the docking results exhibited that the 5c, 6f and 6 g have lowest docking scores -4.790,-4.755, and -4.730, respectively. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yagiz, G; Noma, SAA; Altundas, A; Al-khafaji, K; Taskin-Tok, T; Ates, B or concate me.. Category: indole-building-block
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles