In 2019.0 BIOORG MED CHEM LETT published article about EG5; DISCOVERY; KINESIN-5; PROTEIN; AURORA in [Dumas, Megan E.; Kendrick, Nicole D.] Vanderbilt Univ, Dept Cell & Dev Biol, Nashville, TN 37232 USA; [Chen, Geng-Yuan; Hancock, William] Penn State Univ, Dept Biomed Engn, State Coll, PA USA; [Xu, George; Ohi, Ryoma] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA; [Larsen, Scott A.] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA; [Jana, Somnath; Waterson, Alex G.] Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA; [Waterson, Alex G.; Sulikowski, Gary A.] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA; [Waterson, Alex G.] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA; [Bauer, Joshua A.] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA; [Ohi, Ryoma] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA; [Chen, Geng-Yuan] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA in 2019.0, Cited 30.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4
The mitotic spindle is a microtubule-based machine that segregates a replicated set of chromosomes during cell division. Many cancer drugs alter or disrupt the microtubules that form the mitotic spindle. Microtubule-dependent molecular motors that function during mitosis are logical alternative mitotic targets for drug development. Eg5 (Kinesin-5) and Kif15 (Kinesin-12), in particular, are an attractive pair of motor proteins, as they work in concert to drive centrosome separation and promote spindle bipolarity. Furthermore, we hypothesize that the clinical failure of Eg5 inhibitors may be (in part) due to compensation by Kif15. In order to test this idea, we screened a small library of kinase inhibitors and identified GW108X, an oxindole that inhibits Kif15 in vitro. We show that GW108X has a distinct mechanism of action compared with a commercially available Kif15 inhibitor, Kif15-IN-1 and may serve as a lead with which to further develop Kif15 inhibitors as clinically relevant agents.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Dumas, ME; Chen, GY; Kendrick, ND; Xu, G; Larsen, SA; Jana, S; Waterson, AG; Bauer, JA; Hancock, W; Sulikowski, GA; Ohi, R or concate me.. Product Details of 100-83-4
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles