A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues was written by Chen, Chou-Hsiung;Genapathy, Sivaneswary;Fischer, Peter M.;Chan, Weng C.. And the article was included in Organic & Biomolecular Chemistry in 2014.Reference of 827-01-0 This article mentions the following:
A facile route has been established for the synthesis of indole-substituted (S)-tryptophans from corresponding indoles, which utilizes a chiral auxiliary-facilitated Strecker amino acid synthesis strategy. The chiral auxiliary reagents evaluated were (S)-methylbenzylamine and related derivatives To illustrate the robustness of the method, eight optically pure (S)-tryptophan analogs were synthesized, which were subsequently used for the convergent synthesis of a potent antibacterial agent, argyrin A, and its analogs. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Reference of 827-01-0).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 827-01-0
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles