Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives was written by Chen, Grace Shiahuy;Bhagwat, Bhalchandra V.;Liao, Pei-Yin;Chen, Hui-Ting;Lin, Shwu-Bin;Chern, Ji-Wang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.SDS of cas: 774-47-0 This article mentions the following:
Aminopropylamino indolo[2,1-b]quinazolinediones I•HX (R = H, Me; R1 = H, F; X = F3CCO2, Cl) are prepared; the stabilization of a DNA triplex relative to its duplex by the aminopropylaminoindoloquinazolinediones is determined by UV and CD spectra and the changes in melting temperature The presence of either a fluorine substituent on the indoloquinazolinedione ring or of a Me group on the amino nitrogen attached to the indoloquinazolinedione ring improves the ability of the aminopropyl indoloquinazolinediones to stabilize DNA triplexes. The min. energy conformations of I (R = H, Me; R1 = F) are determined by DFT calculations; the orientation of the aminopropylamino side chain of I (R = Me; R1 = F) underlies its ability to stabilize a DNA triplex. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0SDS of cas: 774-47-0).
5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 774-47-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles