On November 15, 2021, Chen, Xin-Meng; Zhu, Ling; Chen, Dian-Feng; Gong, Liu-Zhu published an article.Category: indole-building-block The title of the article was Chiral Indoline-2-carboxylic Acid Enables Highly Enantioselective Catellani-type Annulation with 4-(bromomethyl)cyclohexanone. And the article contained the following:
Chiral indoline-2-carboxylic acid was identified to enable a highly enantioselective Catellani-type annulation of (hetero)aryl, alkenyl triflate and conjugated vinyl iodides with 4-(bromomethyl)cyclohexanone, directly assembling a diverse range of chiral all-carbon bridged ring systems, e.g., I. Control experiments and DFT calculations suggested that the coordinating orientation of the chiral amino acid to the arylpalladium(II) center allowed for high levels of stereochem. control. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Category: indole-building-block
The Article related to tetrahydro methanocyclooctanaphthalenone enantioselective preparation, enantioselective preparation tetrahydro methanocyclooctaquinolinedione, c−h activation, asymmetric catellani annulation, chiral amines, cooperative catalysis, palladium and other aspects.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles