One-pot three-component reactions of methyl ketones, phenols and a nucleophile: an expedient way to synthesize densely substituted benzofurans was written by Cheng, Cheng;Liu, Changhui;Gu, Yanlong. And the article was included in Tetrahedron in 2015.HPLC of Formula: 3484-23-9 This article mentions the following:
Three-component reactions of glyoxals R1C(O)CHO (R1 = C6H5, 1-benzofuran-2-yl, cyclopropyl, etc.), sesamol/1,4-benzenediol/1,2,4-benzenetriol/phenol and indoles I (R2 = H, CH3, C6H5, CO2CH2CH3; R3 = H, Et; R4 = H, 6-NO2, 5-CH3) were developed with the aid of acid-catalyst, which produced various densely substituted benzofurans e.g., II with good to excellent yields. On the basis of this observation, a one-pot, step-wise reaction was developed by using Me ketones R5C(O)CH3 (R5 = t-Bu, Ph, fluoren-2-yl, thiophen-2-yl, etc.) instead of using glyoxal component in I2/DMSO system. The indole component can be replaced by some other nucleophiles, such as 1,2,4-trimethoxybenzene and thiophenol. In the experiment, the researchers used many compounds, for example, 2-Methyl-6-nitro-1H-indole (cas: 3484-23-9HPLC of Formula: 3484-23-9).
2-Methyl-6-nitro-1H-indole (cas: 3484-23-9) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 3484-23-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles