《Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities》 was written by Cheng, Li-Ting; Luo, Sheng-Qi; Hong, Bor-Cherng; Chen, Chia-Ling; Li, Wen-Shan; Lee, Gene-Hsiang. Formula: C8H6FNThis research focused ontrisindolone preparation antitumor crystal structure mol; indole oxidative trimerization photocatalyst water assisted. The article conveys some information:
A series of trisindolones I [R = H, 5-Me, 6-Br, etc.] was synthesized via water assisted visible-light photocatalyzed oxidative trimerization of indoles under mild and scalable reaction conditions. Compounds I were evaluated against three human cancer cell lines (MDA-MB-231, A549 and HeLa). Compound I [R = 5-I] represented a potent, micromolar to submicromolar range anticancer agent against MDA-MB-231, A549 and HeLa cells. The successful example of the catalyst-free CFL irradiation of 5-iodo-1H-indole provided a green, natural, and convenient synthetic process of compound I [R = 5-I]. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C8H6FN
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles