Synthesis of protected indoles from N-(tert-butoxycarbonyl)-2-alkylanilines was written by Clark, Robin D.;Muchowski, Joseph M.;Souchet, Michel;Repke, David B.. And the article was included in Synlett in 1990.Recommanded Product: 129822-48-6 This article mentions the following:
Lithiation of N-(tert-butoxycarbonyl)-2-alkylanilines and sequential condensation with Me2NCHO and elimination gave N-(tert-butyoxycarbonyl)indoles I (R = H, Me, Ph; R1 = H, 3-F, 3-Cl, 4-Cl, 4-F, 4-MeO, 4-Me). Lithiation of N-(tert-butoxycarbonyl)-2-methylaniline and reaction with (MeO)MeNCOR2 (R2 = Me, Ph) and sequential elimination gave 2-methyl- and 2-phenylindole, resp. In the experiment, the researchers used many compounds, for example, tert-Butyl 5-chloro-1H-indole-1-carboxylate (cas: 129822-48-6Recommanded Product: 129822-48-6).
tert-Butyl 5-chloro-1H-indole-1-carboxylate (cas: 129822-48-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 129822-48-6
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles