Reactions of phthalaldehyde with ammonia and amines was written by Do Minh, T.;Johnson, A. L.;Jones, J. E.;Senise, P. P. Jr.. And the article was included in Journal of Organic Chemistry in 1977.Reference of 5388-42-1 This article mentions the following:
Reactions of phthaladehyde with NH3 and amines are described. Major products from NH3 were phthalimidine and 3-(2-cyanophenyl)isoquinoline. Primary amines RNH2 (R = Me, Ph, etc.) reacted with 2 moles of aldehyde to produce N-substituted adducts I, II whose steric requirements lead to unusual NMR spectra. At elevated temperatures unidentified colored materials were formed. 1-Hydroxyisoindoles are proposed intermediates. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Reference of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Reference of 5388-42-1
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles