162100-95-0, 6-Fluoro-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 6-fluoro-5-methyl-1 H-indole [CAS 162100-95-0] (1.7 g, 11 .4 mmol) in CH2CI2 (100 mL) was cooled to 0C under N2-atmosphere. A solution of diethylaluminum chloride 1M in hexane (17.1 mL, 17.1 mmol) was added dropwise and the resulting mixture was kept at 0C for 15 mm. A solution of 2-(4-chloro-2-methoxyphenyl)acetyl chloride 9a? (3.50 g, 16 mmol) in CH2CI2 (50 mL) was added dropwise. Stirring was continued at 0C for 1 h and the reaction mixture was subsequently stirred at room temperature for 2 h. The reaction mixture was poured out into a stirring ice/Rochelle salt solution. After the ice had melted, the mixture was filtered over dicalite and the filter cake was washed several times with THE.The filtrates were combined. The layers were separated and the organic layer was washed with brine, dried over Mg504, filtered and evaporated under reduced pressure. The solid residue was suspended in CH2CI2 (30 mL) and the precipitate was filtered off and dried under vacuum at 500C to provide 2-(4-chloro-2- methoxyphenyl)-1 -(6-fluoro-5-methyl-1 H-indol-3-yl)ethanone 9a (2.76 g)., 162100-95-0
The synthetic route of 162100-95-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothee Alice Marie-Eve; BONFANTI, Jean-Francois; COESEMANS, Erwin; KESTELEYN, Bart Rudolf Romanie; MARCHAND, Arnaud Didier M; RABOISSON, Pierre Jean-Marie Bernard; (96 pag.)WO2017/167952; (2017); A1;,
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