170147-29-2, As the paragraph descriping shows that 170147-29-2 is playing an increasingly important role.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170147-29-2,tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 1,1 -dimethylethyl 5-[(phenylmethyl)oxy]-lH-indole-l -carboxylate(1.76 g, 4.8 mmol) in tetrahydrofuran (10 mL) was added triisopropyl borate (2.2 mL, 9.5 mmol). The solution was stirred in an ice-water bath under a nitrogen atmosphere and lithium diisopropylamide (2 M in heptane/tetrahydrofuran/ethylbenzene) (4 mL, 8 mmol) was added, portionwise, over 20 min. The reaction mixture was swirled to facilitate mixing, then stirred with cooling for 45 m. Lithium diisopropylamide (2 M in heptane/tetrahydrofuran/ethylbenzene) (0.8 mL, 1.6 mmol) was added to the reaction mixture over a 5-min period. The cold reaction mixture was swirled to facilitate mixing, then stirred for 75 min. Hydrochloric acid (1 N) (50 mL) was added to the reaction mixture and the aqueous mixture was extracted with ethyl acetate. The organic extract was washed with water followed by saturated sodium chloride, dried over magnesium sulfate, filtered, and the filtrate was concentrated to give 2.03 (100%) of {l-{[(l,l-dimethylethyl)oxy]carbonyl}-5-[(phenylmethyl)oxy]-l/f-indol- 2-yl}boronic acid as a tan solid. 1U NMR (400 MHz, DMSO-J6): delta 8.15 (s, 2H), 7.93 (d, J = 9 Hz, IH), 7.44 (d, 2H), 7.37 (m, 2H), 7.30 (m, IH), 7.15 (d, J = 2 Hz, IH), 6.94 (dd, J = 9, 2 Hz, IH), 6.51 (s, IH), 5.09 (s, 2H), 1.56 (s, 9H).
170147-29-2, As the paragraph descriping shows that 170147-29-2 is playing an increasingly important role.
Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/5998; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles