With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.245-08-9,5H-Pyrido[3,2-b]indole,as a common compound, the synthetic route is as follows.
Sub 1-3(4) round bottom flask (3.36g, 20mmol), Sub 1-2 (1) (4g, 20mmol), Pd2(dba) 3 (0.9g, 1mmol), PPh3 (0.5g, 2mmol) , the reaction proceeds at 100 C afterloading the NaOt-Bu (5.8g, 60mmol), toluene (210 mL). After completion of reaction,the organic layer was dried over MgSO4, and extracted with water and ether andrecrystallized silicagel column and the resulting organics concentrated to give 4.9g andthen the Sub 1 (B) -1. (Yield: 74%)
245-08-9, 245-08-9 5H-Pyrido[3,2-b]indole 6451402, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; DUK SAN NEOLUX CO., LTD.; PARK, JEONG KEUN; KIM, SEUL GI; PARK, HYOUNG KEUN; CHO, HYE MIN; PARK, JONG GWANG; KIM, SEOK HYEON; MOON, SOUNG YOON; LEE, TAE WON; (60 pag.)KR2015/121394; (2015); A;,
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