With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31241-19-7,5-Methoxy-2,3,3-trimethyl-3H-indole,as a common compound, the synthetic route is as follows.,31241-19-7
5-Methoxy-2,3,3-trimethyl-3H-indole 12 g (0,063 mol) was dissolved in toluene (20 ml), condenser was attached to the flask and acethyl chloride 9 ml (p=1.104 g/Ml, 9,94 g) was added dropwise. After cooling the mixture to ambient temperature, the mixture was stored at 5 C. for 12 h. Formed crystals were filtered, washed with acetone and cold ether. Yield is 6.6 g of indolium chloride (46.12%) as yellowish crystals. M.p. 201-203 C. 1H NMR (400 MHz, DMSO-D6): delta 1.45 (s, 6H, 2*CH3), 2.62 (s, 3H, 2-CH3), 3.82 (s, 3H, 5-OCH3), 7.02 (dd, J=8.8 Hz, J=2.4 Hz, 1H, 6-H), 7.37 (d, J=2.4 Hz, 1H, 4-H), 7.54 (d, J=8.4 Hz, 1H, 7-H). 13C BMR (100 MHz, DMSO-D6): delta 14.3, 22.0 (2*C), 53.8, 55.9, 109.4, 113.9, 117.2, 134.9, 145.3, 159.7, 193.0. IR (KBr), nu (cm-1): 3134 (N-H), 3021, 2973, 1623, 1479, 1404, 1289, 1022, 797.
The synthetic route of 31241-19-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; KAUNAS UNIVERDITY OF TECHNOLOGY; SACKUS, Algirdas; Marynaitis, Vytas; Krikstolaityt, Sonata; Ragaite, Greta; Vengris, Mikas; (12 pag.)US2017/355709; (2017); A1;,
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