Name: 3-Hydroxybenzaldehyde. Authors Oliveira, GHC; Ramos, LM; de Paiva, RKC; Passos, STA; Simoes, MM; Machado, F; Correa, JR; Neto, BAD in ROYAL SOC CHEMISTRY published article about in [Oliveira, Gabriela H. C.; Ramos, Luciana M.; de Paiva, Raissa K. C.] Univ Estadual Goias, Lab Quim Med & Sintese Organ LaQuiMeSO, Campus Ciencias Exatas & Tecnol, CP 459, Anapolis, Go, Brazil; [Passos, Saulo T. A.; Machado, Fabricio; Correa, Jose R.; Neto, Brenno A. D.] Univ Brasilia, Chem Inst IQ UnB, Lab Med & Technol Chem, Campus Univ Darcy Ribeiro, BR-70904900 Brasilia, DF, Brazil; [Simoes, Marina M.; Correa, Jose R.] Univ Brasilia, Inst Ciencias Biol, Dept Biol Celular, Lab Microscopia & Microanal, Brasilia, DF, Brazil; [Machado, Fabricio] Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England in 2021, Cited 112. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
In this work, we describe the application of a synthetic enzyme (synzyme) as the catalyst to promote the multicomponent synthesis of isoxazol-5(4H)-one derivatives. The catalytic system could be used up to 15 times without any notable loss of its activity. Some derivatives showed fluorescence and their photophysical data were evaluated. The mechanism of the reaction was, for the first time, investigated and, among the three reaction pathway possibilities, only one was operating under the developed conditions. ESI-MS(/MS) allowed for both the simultaneous monitoring of the multicomponent reaction (MCR) and the proposition of a kinetic model to explain the transformation. The kinetic model pointed firmly to only one reaction pathway and helped to discard the other two possibilities. The antimicrobial abilities of all synthesized derivatives against Gram-positive and Gram-negative strains were also evaluated. The abilities of functional chromophores (fluorescent compounds) as live cell-imaging probes were verified and one of the multicomponent adducts could stain early endosomes selectively in bioimaging experiments.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles