Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R in [Vaitkiene, Simona; Kuliesiene, Neringa; Sakalauskaite, Sandra; Daugelavicius, Rimantas] Vytautas Magnus Univ, Dept Biochem, Kaunas, Lithuania; [Bekere, Laura; Krasnova, Laura; Vigante, Brigita; Duburs, Gunars] Latvian Inst Organ Synth, Riga, Latvia published Antifungal activity of styrylpyridinium compounds againstCandida albicans in 2021.0, Cited 39.0. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.
We synthesized a set of 13 new and earlier described styrylpyridinium compounds (N-alkyl styrylpyridinium salts with bromide or tosylate anions) in order to evaluate antifungal activity againstC. albicanscells, to assay the possible synergism with fluconazole, and to estimate cytotoxicity to mammalian cells. All compounds were synthesized according to a well-known two-step procedure involving alkylation of gamma-picoline with appropriate alkyl bromide and further condensation with substituted benzaldehyde. Compounds with longN-alkyl chains(C18H37-C20H41) had no antifungal activity against the cells of all testedC. albicansstrains. Other styrylpyridinium compounds were able to inhibit yeast growth at the concentrations of 0.06-16 mu g/ml. At fungicidal concentrations, the compound with the CN- group was least toxic to mammalian cells, showed the most effective synergism with fluconazole, and only slightly inhibited the respiration ofC. albicans. The compound with the 4 ‘-diethylamino group exhibited the strongest fungicidal properties and effectively blocked the respiration ofC. albicanscells. However, toxicity to mammalian cells was also high. Summarizing, the results of our study indicate that styrylpyridinium compounds are promising candidates in the development of new antifungal drugs.
COA of Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles