An article Formal enantioselective synthesis of nhatrangin A WOS:000519640500012 published article about MICHAEL ADDITION; APLYSIATOXIN DERIVATIVES; STEREOSELECTIVE ACCESS; DEBROMOAPLYSIATOXIN; ALDEHYDES; STEREOCHEMISTRIES; INHIBITION; EFFICIENT; ALCOHOLS; CATALYST in [Feuillastre, Sophie; Raffier, Ludovic; Pelotier, Beatrice; Piva, Olivier] Univ Claude Bernard Lyon 1, Univ Lyon, Inst Chim & Biochim Mol & Supramol, MIR 5246,Equipe SURCOOF,CNRS,INSA Lyon,CPE Lyon, Bat Raulin,43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France in 2020.0, Cited 50.0. Application In Synthesis of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
A new and straightforward synthesis of the C-1-C-7 core fragment of nhatrangin A was achieved in 14 steps from achiral 3-hydroxybenzaldehyde, without the need of chiral reagents or enzymatic resolution to introduce the chiral centers. The key asymmetric steps include in particular a highly enantioselective organocatalyzed Michael addition on an aryl vinyl ketone, a Sharpless asymmetric epoxidation and a subsequent regioselective ring opening of the resulting chiral epoxide. This work represents the first formal enantioselective synthesis of nhatrangin A.
Application In Synthesis of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Feuillastre, S; Raffier, L; Pelotier, B; Piva, O or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles