Extracurricular laboratory: Synthetic route of C8H8O2

Welcome to talk about 99-93-4, If you have any questions, you can contact Boudreau, MA; Ding, DR; Meisel, JE; Janardhanan, J; Spink, E; Peng, ZH; Qian, YY; Yamaguchi, T; Testero, SA; O’Daniel, PI; Leemans, E; Lastochkin, E; Song, W; Schroeder, VA; Wolter, WR; Suckow, MA; Mobashery, S; Chang, M or send Email.. Product Details of 99-93-4

An article Structure-Activity Relationship for the Oxadiazole Class of Antibacterials WOS:000526401400022 published article about PLASMA-PROTEIN BINDING; UPDATE; DRUGS in [Boudreau, Marc A.; Ding, Derong; Meisel, Jayda E.; Janardhanan, Jeshina; Spink, Edward; Peng, Zhihong; Qian, Yuanyuan; Yamaguchi, Takao; Testero, Sebastian A.; O’Daniel, Peter I.; Leemans, Erika; Lastochkin, Elena; Song, Wei; Mobashery, Shahriar; Chang, Mayland] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA; [Schroeder, Valerie A.; Wolter, William R.; Suckow, Mark A.] Univ Notre Dame, Freimann Life Sci Ctr, Notre Dame, IN 46556 USA; [Schroeder, Valerie A.; Wolter, William R.; Suckow, Mark A.] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA in 2020.0, Cited 12.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.

Welcome to talk about 99-93-4, If you have any questions, you can contact Boudreau, MA; Ding, DR; Meisel, JE; Janardhanan, J; Spink, E; Peng, ZH; Qian, YY; Yamaguchi, T; Testero, SA; O’Daniel, PI; Leemans, E; Lastochkin, E; Song, W; Schroeder, VA; Wolter, WR; Suckow, MA; Mobashery, S; Chang, M or send Email.. Product Details of 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles