In 2019,Mendeleev Communications included an article by Feofanov, Mikhail N.; Averin, Alexei D.; Beletskaya, Irina P.. Synthetic Route of C8H6FN. The article was titled 《Friedel-Crafts reaction of electron-rich (het)arenes with nitroalkenes》. The information in the text is summarized as follows:
The Friedel-Crafts reaction between electron-rich (het)arenes and β-nitrostyrenes under MgI2 or Ca(NTf2)2 catalysis afforded 1-(het)aryl-2-nitro-1-phenylethanes in yields up to 94%. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Synthetic Route of C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Synthetic Route of C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles