Reference of 284028-89-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 284028-89-3, Name is XAV-939, SMILES is O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1, belongs to indole-building-block compound. In a article, author is Yang, Lisheng, introduce new discover of the category.
Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate
Unprecedented Rh(III)-catalyzed C-H bond difluorovinylation of indoles has been successfully developed, and this method provided an example of direct difluorovinylation reaction through C-H bond activation which was rarely reported. In this context, N-ethoxycarbamoyl served as the directing group and 2,2-difluorovinyl tosylates were used for the construction of difluorovinyl-substituted indoles. This method provided a practical strategy for difluorovinylation of indoles with moderate to good yields and is characterized by the broad synthetic utility, mild conditions, and high efficiency.
Reference of 284028-89-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 284028-89-3.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles