Recently I am researching about MULTITARGET-DIRECTED LIGANDS; ALZHEIMERS-DISEASE; BIOLOGICAL EVALUATION; CHOLINESTERASE-INHIBITORS; POTENTIAL TREATMENT; MULTIPOTENT MAO; DONEPEZIL; NEUROPROTECTION; HYBRIDS; DESIGN, Saw an article supported by the DST-SERB [EMR/2015/002339, ECR/2015/000240]; Central University of Punjab, Bathinda [RSM GP25]; CUP, Bathinda; CSIRCouncil of Scientific & Industrial Research (CSIR) – India; UGCUniversity Grants Commission, India. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. COA of Formula: C7H6O2
Alzheimer’s disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years’ different pharmacological strategies including multi-targeting agents are being explored for the effective drug development for AD. A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. All the compounds were found to be selective and reversible inhibitors of MAO-B isoform. These compounds also displayed good AChE inhibition potential with IC50 values in low micromolar range. AVB4 was found to be the most potent MAO-B inhibitor with IC50 value of 1.49 +/- 0.09 mu M and AVB1 was found to be the most potent AChE inhibitor with IC50 value of 135 +/- 0.03 mu M. In the ROS protection inhibition studies, AVB1 and AVB4 displayed weak but interesting activity in SH-SYSY cells. In the cytotoxicity studies involving SH-SY5Y cells, both AVB1 and AVB4 were found to be non-toxic to the tissue cells. In the molecular dynamic simulation studies of 30 ns, the potent compounds were found to be quite stable in the active site of MAO-B and AChE. The results suggested that AVB1 and AVB4 are promising dual inhibitors and have the potential to be developed as anti-Alzheimer’s drug. (C) 2019 Published by Elsevier Masson SAS.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V or concate me.. COA of Formula: C7H6O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles