Chemistry is an experimental science, Recommanded Product: 53855-47-3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 53855-47-3, Name is Ethyl 2-methyl-1H-indole-3-carboxylate
Multiple Roles of the Pyrimidyl Group in the Rhodium-Catalyzed Regioselective Synthesis and Functionalization of Indole-3-carboxylic Acid Esters
A regioselective synthesis of indole-3-carboxylic acid esters from anilines and diazo compounds has been realized by making use of the pyrimidyl group-assisted rhodium-catalyzed C-H activation and C-N bond formation. The reaction proceeds under mild conditions, exhibits good functional group tolerance and scalability. Reutilization of the pyrimidyl directing group in the resulting products provided an efficient strategy for further C-7 functionalization of indoles. Moreover, the pyrimidyl moiety could be readily removed as a leaving group to offer various free N-H indoles.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 53855-47-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 53855-47-3, in my other articles.
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles