Computed Properties of C8H8O2. In 2020.0 POLYM CHEM-UK published article about BLOCK-COPOLYMERS; POTENTIAL APPLICATIONS; POLYMERIC MICELLES; DELIVERY; AZOBENZENE; PROBES; DESIGN; NANOPARTICLES; VESICLES; TUMOR in [Wang, Yuqing; Yu, Jiawei; Wang, Zhe; Iqbal, Shahid; Zhang, Wei; Zhang, Zhengbiao; Zhou, Nianchen; Zhu, Xiulin] Soochow Univ, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China; [Wang, Yuqing; Yu, Jiawei; Wang, Zhe; Iqbal, Shahid; Zhang, Wei; Zhang, Zhengbiao; Zhou, Nianchen; Zhu, Xiulin] Soochow Univ, Jiangsu Key Lab Adv Funct Polymer Design & Applic, Suzhou 215123, Peoples R China; [Wang, Yuqing; Yu, Jiawei; Wang, Zhe; Iqbal, Shahid; Zhang, Wei; Zhang, Zhengbiao; Zhou, Nianchen; Zhu, Xiulin] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Zhu, Xiulin] Global Inst Software Technol, 5 Qingshan Rd, Suzhou 215163, Peoples R China in 2020.0, Cited 62.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
A near-infrared fluorescent probe plays an important role in biosensing and bioimaging because of its high efficiency, sensitivity and negligible background interference in vivo. Azobenzene derivatives demonstrate well-known sensitivity to light and are unique enzyme-responsive candidates in drug delivery and biological detection because the azo double bond can be cleaved by azoreductase. Herein, a novel near-infrared probe of an amphiphilic block copolymer with biological compatibility was synthesized. The azobenzene group attached with the near-infrared fluorescent group AzaBODIPY (boron-dipyrromethenes) linked the hydrophilic (PEG) and hydrophobic (PLA) segments to form the amphiphilic block copolymer PEG-AzaBODIPY-AZO-PLA. PEG(398)-AzaBODIPY-AZO-PLA(144) self-assembled into drug-loaded spherical micelles. The self-assemblies were non-fluorescent owing to the aggregation-induced quenching (ACQ) effect. Triggered by azoreductase, the PEG and PLA segments were disconnected due to the cleavage of the azo bond. This caused the disassembly of the micelles and the subsequent release of the encapsulated drug. Upon disassembly, the emission of the near-infrared fluorescence was activated by the elimination of the ACQ effect. Furthermore, the fluorescence intensity of the self-assemblies in solution increased continuously with drug release. The fluorescence reporting drug release demonstrates the potential applications in biosensing and controlled drug release in the colon of the human intestine.
Computed Properties of C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wang, YQ; Yu, JW; Wang, Z; Iqbal, S; Zhang, W; Zhang, ZB; Zhou, NC; Zhu, XL or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles