An article Amino acid-based compound activates atypical PKC and leptin receptor pathways to improve glycemia and anxiety like behavior in diabetic mice WOS:000518868700004 published article about GLUCOSE-TRANSPORTER GLUT1; BLOOD-BRAIN-BARRIER; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; ADIPOSE-TISSUE; MUSCLE-CELLS; BODY-WEIGHT; METABOLISM; DYSFUNCTION; ADIPOCYTES in [Lee, Aejin; Song, No-Joon; Leung, Jacob H.; Kowdley, Devan; Wall, Jennifer; Ziouzenkova, Ouliana] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA; [Sun, Yuan; Lin, Tao; Mason, McKensie L.; Brunetti, Alessandro; Parquette, Jon R.] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA; [Fitzgerald, Julie; Weil, Zachary] Ohio State Univ, Dept Neurosci, Wexner Med Ctr, Columbus, OH 43210 USA; [Baer, Lisa A.; Stanford, Kristin I.] Ohio State Univ, Dept Physiol & Cell Biol, Dorothy M Davis Heart & Lung Res Inst, Columbus, OH 43210 USA; [Ortega-Anaya, Joana; Jimenez-Flores, Rafael] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA; [Gomes-Dias, Laisa; Blakeslee, Joshua J.] Ohio State Univ, Dept Hort & Crop Sci, OARDC, Columbus, OH 44691 USA; [Needleman, Bradley; Noria, Sabrena] Ohio State Univ, Wexner Med Ctr, Ctr Minimally Invas Surg, Comprehens Weight Management & Bariatr Surg Progr, Columbus, OH 43210 USA in 2020.0, Cited 86.0. Recommanded Product: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Differences in glucose uptake in peripheral and neural tissues account for the reduced efficacy of insulin in nervous tissues. Herein, we report the design of short peptides, referred as amino acid compounds (AAC) with and without a modified side chain moiety. At nanomolar concentrations, a candidate therapeutic molecule, AAC2, containing a 7-(diethylamino) coumarin-3-carboxamide side-chain improved glucose control in human peripheral adipocytes and the endothelial brain barrier cells by activation of insulin-insensitive glucose transporter 1 (GLUT1). AAC2 interacted specifically with the leptin receptor (LepR) and activated atypical protein kinase C zeta (PKC sigma) to increase glucose uptake. The effects induced by AAC2 were absent in leptin receptor-deficient predipocytes and in Lepr(db) mice. In contrast, AAC2 established glycemic control altering food intake in leptin-deficient Lep(ob) mice. Therefore, AAC2 activated the LepR and acted in a cytokine-like manner distinct from leptin. In a monogenic Ins2(Akita) mouse model for the phenotypes associated with type 1 diabetes, AAC2 rescued systemic glucose uptake in these mice without an increase in insulin levels and adiposity, as seen in insulin-treated Ins2(Akita) mice. In contrast to insulin, AAC2 treatment increased brain mass and reduced anxiety-related behavior in ins2(Akita) mice. Our data suggests that the unique mechanism of action for AAC2, activating LepR/PKC sigma/GLUT1 axis, offers an effective strategy to broaden glycemic control for the prevention of diabetic complications of the nervous system and, possibly, other insulin insensitive or resistant tissues.
About Benzyl Alcohol, If you have any questions, you can contact Lee, A; Sun, Y; Lin, T; Song, NJ; Mason, ML; Leung, JH; Kowdley, D; Wall, J; Brunetti, A; Fitzgerald, J; Baer, LA; Stanford, KI; Ortega-Anaya, J; Gomes-Dias, L; Needleman, B; Noria, S; Weil, Z; Blakeslee, JJ; Jimenez-Flores, R; Parquette, JR; Ziouzenkova, O or concate me.. Recommanded Product: 100-51-6
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles