On January 1, 2018, He, Yi; Li, Zhenghua; Robeyns, Koen; Van Meervelt, Luc; Van der Eycken, Erik V. published an article.HPLC of Formula: 883526-76-9 The title of the article was A Gold-Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks. And the article contained the following:
We report herein an efficient gold(I)-catalyzed post-Ugi domino dearomatization/ipso-cyclization/Michael sequence that enables access to libraries of diverse (hetero)arene-annulated tricyclic heterocycles. This process affords novel complex polycyclic scaffolds in moderate to good yields from readily available acyclic precursors with excellent chemo-, regio-, and diastereoselectivity. The power of this strategy has been demonstrated by the rapid synthesis of 40 highly functionalized polyheterocycles bearing indole, pyrrole, (benzo)furan, (benzo)thiophene, pyrazole, and electron-rich arene groups in two operational steps. Thus, e.g., treatment of Ugi adduct I with IPrAuCl/AgOTf afforded polyheterocycle II (96%). The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9
The Article related to gold catalyzed domino cyclization diverse polyheterocyclic compound synthesis, chemoselective synthesis polyheterocyclic compound, regioselective synthesis polyheterocyclic compound, diastereoselective synthesis polyheterocyclic compound, ugi reaction, dearomatization, domino cyclization, gold catalysis, heterocycles and other aspects.HPLC of Formula: 883526-76-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles