Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine was written by Hemenway, Jeffrey N.;Nti-Addae, Kwame;Guarino, Victor R.;Stella, Valentino J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.COA of Formula: C14H9NO2S This article mentions the following:
Improved synthetic methods were reported for the preparation of sulfenamide derivatives I [R = SPh, SCH2CH(NH2)CO2Et, S(CH2)2NH2] of carbamazepine (CBZ) I (R = H) for evaluation as prodrugs. These sulfenamide prodrugs were designed to rapidly release CBZ in vivo by cleavage of the sulfenamide bond by chem. reaction with glutathione and other sulfhydryl compounds Physicochem. characterization and in vivo conversion of the new prodrug I [R = S(CH2)2NH2] of CBZ was evaluated to further establish the proof of concept of the sulfenamide prodrug approach. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4COA of Formula: C14H9NO2S).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.COA of Formula: C14H9NO2S
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles