SDS of cas: 100-51-6. Schutte, RJ; Zhang, XJ; An, N; Ostrov, DA; Vukmanovic, S in [Schutte, Ryan J.; Zhang, Xiaojuan; Ostrov, David A.] Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL 32611 USA; [An, Nan; Vukmanovic, Stanislav] US FDA, Div Cosmet, Off Cosmet & Colors, CFSAN, College Pk, MD USA published Molecular docking predictions of fragrance binding to human leukocyte antigen molecules in 2019.0, Cited 40.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Background: Over 4000 small chemicals have been identified as allergens capable of inducing skin sensitization. Many sensitizers are hypothesized to act as haptens producing novel antigens, which can be presented to T cells by human leukocyte antigens (HLAs). Recent studies suggest that some chemical allergens use hapten-independent mechanisms. Objective: To determine whether molecular docking can identify HLA molecules that bind skin-sensitizing chemical allergens. Methods: Structural models of HLA molecules were used as the basis for molecular docking of 22 chemical allergens. Allergens predicted to bind HLA-B*57:01 were tested for their ability to stimulate T cells by the use of proliferation and interferon-gamma enzyme-linked immunospot assays. Results: Chemical allergens that did not satisfy the criteria for hapten activity in vitro were predicted to bind more strongly to common HLA isoforms than those with known hapten activity. HLA-B* 57: 01, which is an HLA allele required for drug hypersensitivity reactions, was predicted to bind several allergens, including benzyl benzoate, benzyl cinnamate, and benzyl salicylate. In in vitro T cell stimulation assays, benzyl salicylate and benzyl cinnamate were found to stimulate T cell responses from HLA-B* 57:01 carriers. Conclusions: These data suggest that small-molecule skin sensitizers have the potential to interact with HLA, and show that T cell-based in vitro assays may be used to evaluate the immunogenicity of skin-sensitizing chemicals.
SDS of cas: 100-51-6. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles