Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK in [Zhang, Tian-Yi; Bai, Xue-Qian; Chen, Jiang-Hui; Song, Ze-Wen; Feng, Bo] Jilin Med Univ, Jilin 132013, Jilin, Peoples R China; [Li, Chun-Shi; Cui, Ming-Yue] Third Peoples Hosp Dalian, Dalian 116000, Peoples R China; [Chen, Jiang-Hui; Song, Ze-Wen] Yanbian Univ, Dept Pharm, Yanji 133002, Peoples R China; [Liu, Xue-Kun] Tonghua Normal Univ, Sch Pharm Med, Tonghua 134002, Jilin, Peoples R China published Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents in 2021, Cited 21. Computed Properties of C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.
In the present investigation, a series of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties were synthesized and their structures were confirmed by different spectral tools. The biological evaluation in vitro revealed that some of the target compounds exerted good antibacterial and antifungal activity in comparison with the reference drugs. Among these novel hybrids, compound 10d showed the most potent activity with minimum inhibitory concentration values (MIC) of 0.5 mu g/mL againstS. aureus4220, MRSA 3506 and E. coli 1924 strain. The cytotoxic activity of the compounds 6d, 6m,10d and 10g was assessed in MCF-7 and HeLa cells. Growth kinetics study showed significant inhibition of bacterial growth when treated with different conc. of 10d. In vitro enzyme study implied that compound 10d exerted its antibacterial activity through DHFR inhibition. Moreover, significant inhibition of biofilm formation was observed in bacterial cells treated with MIC conc. of 10d as visualized by SEM micrographs. [GRAPHICS] .
Computed Properties of C7H5F3O. Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles