New melanin biosynthesis inhibitors and their structural similarities was written by Inoue, Satoru;Uematsu, Tamon;Kato, Toshiro;Ueda, Kenzo. And the article was included in Pesticide Science in 1985.Synthetic Route of C9H8BrNO The following contents are mentioned in the article:
Relationships between their activities as rice blast (Pyricularia oryzae) control agents and their abilities to inhibit mycelial melanization on a nutrient agar were described for 103 substituted benzothiazol-2(3H)-ones, benzoxazol-2(3H)-ones, indolin-2-ones, quinolin-2(1H)-ones, 1,2,3,4-tetrahydroquinolin-2-ones, benzo-1,4-thiazin-3(2H)-ones and benz-1,4-oxazin-3(2H)-ones, and some corresponding thiones. Several compounds had a high protective activity and an antimelanization activity against P. oryzae. There was good correlation between these activities. Structural similarities of the compounds were identified as: (1) having a benzo-bicyclic ring system; (b) containing a N atom in one ring at a position alpha to the benzene ring system; and (c) substitution, at the ring N atom, at the peri position in the aromatic ring relative to the N atom, and at the position alpha to the N atom in the ring system, with a double bond, such as in carbonyl and thiocarbonyl groups. The findings are discussed in relation to the structures of previously identified melanin biosynthesis inhibitors. This study involved multiple reactions and reactants, such as 7-Bromo-1-methylindolin-2-one (cas: 100831-25-2Synthetic Route of C9H8BrNO).
7-Bromo-1-methylindolin-2-one (cas: 100831-25-2) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C9H8BrNO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles