An article Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro WOS:000465049300019 published article about CHLOROGENIC ACID PROTECTS; GENIPIN PROTECTS; ALPHA-NAPHTHYLISOTHIOCYANATE; ISCHEMIA/REPERFUSION INJURY; RHUBARB ANTHRAQUINONES; D-GALACTOSAMINE; GENIPOSIDE; ANTIOXIDANT; HEPATOTOXICITY; INFLAMMATION in [Tian, Xiaoting; Liu, Huan; Qiao, Shida; Yin, Hao; Chen, Mingcang; Hu, Pei; Wang, Yangyang; Peng, Huige; Liu, Fang; Pan, Guoyu; Huang, Chenggang] Chinese Acad Sci, Shanghai Inst Materia Med, 501 Hai Ke Rd Zhangjiang, Shanghai 201203, Peoples R China; [Tian, Xiaoting; Liu, Huan; Qiao, Shida; Yin, Hao; Chen, Mingcang; Hu, Pei; Wang, Yangyang; Peng, Huige; Liu, Fang; Pan, Guoyu; Huang, Chenggang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4
Ethnopharmacological relevance: Yin-Chen-Hao Tang (YCHT) has been a very popular, hepatoprotective three-herb formula with an unclear chemical base. Aim of this study: To reveal the hepatoprotective chemical base of oral-dosed YCHT, we bridged the hepatic disposition of six compounds in vivo and their hepatoprotection in vitro. Materials and methods: In vivo, following the oral administration of YCHT in normal and CCl4-induced liver injury rats, the determinations of chlorogenic acid, 4-hydroxyacetophenone, geniposide, genipin, rhein and emodin were conducted in the portal vein plasma, the liver, and the systemic plasma. In vitro, the hepatoprotective activities of these compounds were determined in the CCl4-induced HepG2 cells. Results: Consistent with the highest content in YCHT, geniposide had the highest exposure in vivo. Inconsistent with the negligible content, rhein, 4-hydroxyacetophenone, emodin and genipin showed substantial hepatic accumulations. In contrast, chlorogenic acid, an ingredient that has a high content in YCHT, elicited no hepatic exposure. In normal rats, the hepatic disposition prevented the compounds entering into the systemic plasma from the portal vein plasma by 44.9-100%, except for rhein. CCl4-induced liver injury caused a decreased hepatic exposure of 4-hydroxyacetophenone, rhein and emodin by 50%. In vitro, all six compounds exerted the hepatoprotection by increasing cell viability, decreasing hepatic marker enzymes and inhibiting lipid peroxidation at varying levels. Conclusion Geniposide, rhein, emodin, 4-hydroxyacetophenone and genipin directly resisted liver injury in oral-dosed YCHT, while chlorogenic acid likely played an indirect role. This study proved that YCHT exerted hepatoprotection through multiple components and multiple actions. However, close attention should be paid to the possible side effects and oral dosage of YCHT in clinics.
Welcome to talk about 99-93-4, If you have any questions, you can contact Tian, XT; Liu, H; Qiao, SD; Yin, H; Chen, MC; Hu, P; Wang, YY; Peng, HG; Liu, F; Pan, GY; Huang, CG or send Email.. Product Details of 99-93-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles